INT91043

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Context Info
Confidence 0.25
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.66
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NDRG1) plasma membrane (NDRG1) nucleus (NDRG1)
cytoplasm (NDRG1)
Anatomy Link Frequency
Caco-2 2
neuron 1
DRG 1
NDRG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nav1.7 6 100.00 Very High Very High Very High
dorsal root ganglion 6 100.00 Very High Very High Very High
hyperexcitability 2 100.00 Very High Very High Very High
nav1.8 3 88.52 High High
psoriasis 6 87.28 High High
Pain 6 80.12 Quite High
sodium channel 4 75.00 Quite High
Potency 1 75.00 Quite High
Congenital analgesia 1 68.68 Quite High
tetrodotoxin 1 38.68 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 100.00 Very High Very High Very High
Colorectal Cancer 2 100.00 Very High Very High Very High
Cancer 131 99.64 Very High Very High Very High
Adhesions 5 98.44 Very High Very High Very High
Breast Cancer 206 87.84 High High
Psoriasis 10 87.28 High High
Recurrence 19 83.96 Quite High
Disease 40 83.52 Quite High
Pain 5 80.12 Quite High
Colon Cancer 16 75.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Caco-2 cells, the differentiation-related gene NDRG1, which is expressed during differentiation and down-regulated in colorectal neoplasms [62], was up-regulated at 12 hrs.
Regulation (regulated) of NDRG1 in Caco-2 associated with colorectal cancer
1) Confidence 0.25 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.40 Pain Relevance 0
In Caco-2 the up-regulation of AQP3, NDRG1 and TFF3 were among the genes that validated the results from the global transcription profile analysis.
Regulation (regulation) of NDRG1 in Caco-2
2) Confidence 0.25 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.22 Pain Relevance 0.07
MammoStrat® uses conventional paraffin-embedded tissue to assay five markers by IHC: tumor protein p53 (TP53) — known to play a central role in cell cycle regulation; Hpa II tiny fragments locus 9C (HTF9C) — involved in DNA replication and cell cycle control; carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) — aberrantly expressed in some cancers; nmyc downstream-regulated gene 1 (NDRG1) — may function as a signaling protein in growth arrest and cellular differentiation; and solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 (SLC7A5) — mediates amino acid transport.
Regulation (regulated) of NDRG1 associated with cancer and adhesions
3) Confidence 0.14 Published 2010 Journal Current Genomics Section Body Doc Link PMC2878980 Disease Relevance 0.80 Pain Relevance 0
Notably WalBC cells showed up regulated expression of DSP, s100A4, ANXA1, NDRG-1, TK1 and down regulation of genes such as tissue inhibitor of TIMP-3 and TAGLN.
Regulation (regulation) of NDRG-1
4) Confidence 0.07 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2263075 Disease Relevance 0.41 Pain Relevance 0
We used voltage- and current-clamp recordings to evaluate the hypothesis that ranolazine may be effective in regulating Nav1.7-induced DRG neuron hyperexcitability.
Regulation (regulating) of DRG in neuron associated with hyperexcitability and nav1.7
5) Confidence 0.06 Published 2010 Journal Mol Pain Section Abstract Doc Link 20529343 Disease Relevance 0.48 Pain Relevance 1.32
From these observations, we conclude that the differences in responsiveness of DRG TTX-i, and ventricular whole cell Na(+) currents to the GTX analogs studied are related to the number of Na(+) channels modified.
Regulation (responsiveness) of DRG TTX-i in DRG associated with dorsal root ganglion
6) Confidence 0.00 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10999938 Disease Relevance 0.35 Pain Relevance 0.25
In addition, the number of previous captures had a positive effect on induction time.
Regulation (effect) of induction
7) Confidence 0.00 Published 2006 Journal BMC Vet Res Section Abstract Doc Link PMC1435748 Disease Relevance 0 Pain Relevance 0

General Comments

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