INT91055

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Context Info
Confidence 0.45
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 5.14
Pain Relevance 4.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm1) nucleus (Grm1) signal transducer activity (Grm1)
Anatomy Link Frequency
neurons 2
hippocampus 2
brain 1
Grm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
GABAergic 64 100.00 Very High Very High Very High
Hippocampus 19 99.98 Very High Very High Very High
antagonist 111 99.96 Very High Very High Very High
Pain 223 99.84 Very High Very High Very High
Arthritis 117 99.74 Very High Very High Very High
agonist 10 97.24 Very High Very High Very High
ischemia 1 95.88 Very High Very High Very High
Glutamate 94 93.72 High High
amygdala 222 93.20 High High
dorsal root ganglion 1 91.68 High High
Disease Link Frequency Relevance Heat
Pain 225 99.84 Very High Very High Very High
Arthritis 197 99.74 Very High Very High Very High
Diabetes Mellitus 8 98.72 Very High Very High Very High
Injury 31 96.92 Very High Very High Very High
Cv Unclassified Under Development 1 95.88 Very High Very High Very High
Cognitive Disorder 10 95.60 Very High Very High Very High
Ganglion Cysts 3 90.72 High High
Depression 8 89.32 High High
Psychosis 8 89.20 High High
Amnesia 4 82.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the hippocampus GluR1 mRNA was significantly decreased.
Negative_regulation (decreased) of GluR1 mRNA in hippocampus associated with hippocampus
1) Confidence 0.45 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0.35 Pain Relevance 0.48
Iversen's study even observed a decreased mRNA levels for mGluR1, mGluR2, mGluR5 and an unchanged mRNA level for mGluR3 in regions of rat brain after transient global ischemia [39].
Negative_regulation (decreased) of mGluR1 in brain associated with ischemia
2) Confidence 0.42 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2242800 Disease Relevance 0.65 Pain Relevance 0.08
However, blocking mGluR1 had no significant effect on evoked EPSCs and sEPSCs in either groups.
Negative_regulation (blocking) of mGluR1
3) Confidence 0.41 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 19840219 Disease Relevance 1.01 Pain Relevance 0.72
In the arthritis pain model, blockade of mGluR1 and mGluR5 decreased the enhanced activity of CeLC neurons to normal-like levels, suggesting a major change in the function of mGluR1 in pain.
Negative_regulation (blockade) of mGluR1 in neurons associated with pain and arthritis
4) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.72 Pain Relevance 0.86
The data suggest that removal of the mGluR1-mediated blockade of inhibitory transmission with an mGluR1 antagonist restores inhibitory control of excitatory synaptic transmission as is evident from the facilitatory effect of a GABAA-receptor antagonist that was lost in the arthritis pain model.
Negative_regulation (removal) of mGluR1 associated with pain, antagonist and arthritis
5) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.68 Pain Relevance 0.65
The data suggest that removal of the mGluR1-mediated blockade of inhibitory transmission with an mGluR1 antagonist restores inhibitory control of excitatory synaptic transmission as is evident from the facilitatory effect of a GABAA-receptor antagonist that was lost in the arthritis pain model.
Negative_regulation (blockade) of mGluR1-mediated associated with pain, antagonist and arthritis
6) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.67 Pain Relevance 0.61
The novel key findings of this study on amygdala function related to pain are as follows. 1) In contrast to the increase in excitatory synaptic transmission, inhibitory feedforward inhibition of CeLC neurons decreases in a model of arthritis pain, shifting the balance toward a dominance of excitatory inputs. 2) The differential change of excitatory and inhibitory transmission involves mGluR1 acting presynaptically on GABAergic terminals to decrease inhibitory and enhance excitatory transmission. 3) Postsynaptic mGluR5 contribute to both excitatory and inhibitory synaptic transmission under normal conditions and in the arthritis pain model; their effect on synaptic inputs does not change in the pain state.
Negative_regulation (decrease) of mGluR1 in neurons associated with pain, gabaergic, amygdala and arthritis
7) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.81 Pain Relevance 0.71
At 14 days, mGluR4 mRNA expression was similar to controls, while mGluR1 mRNA was again reduced.
Negative_regulation (reduced) of mGluR1 mRNA
8) Confidence 0.36 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11000486 Disease Relevance 0.16 Pain Relevance 0.35
In the hippocampus, the AMPA subunit GluR1 mRNA was significantly decreased at the highest dose, Figure 2B.
Negative_regulation (decreased) of GluR1 mRNA in hippocampus associated with hippocampus
9) Confidence 0.29 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0 Pain Relevance 0.05
In this study, we demonstrated that DHPG-induced long-lasting potentiation of AMPA receptors-mediated sEPSC amplitude was completely blocked only when both mGluR1 and mGluR5 were blocked, indicating that a single subtype of group I mGluR is enough for the postsynaptic potentiating effect.
Negative_regulation (blocked) of mGluR1
10) Confidence 0.09 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0.09 Pain Relevance 0.38

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