INT9106

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Context Info
Confidence 0.22
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.92
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F3) aging (F3) cytoplasm (F3)
Anatomy Link Frequency
macrophages 2
Plasma 1
monocyte 1
chest 1
smooth muscle cells 1
F3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 24 99.28 Very High Very High Very High
cytokine 8 92.24 High High
Inflammatory marker 5 91.64 High High
cva 12 86.16 High High
Inflammation 13 85.80 High High
spinal inflammation 2 50.00 Quite Low
aspirin 5 42.16 Quite Low
ischemia 8 21.32 Low Low
Pain 2 10.28 Low Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sickle Cell Anemia 17 99.48 Very High Very High Very High
Cv General 3 Under Development 28 99.28 Very High Very High Very High
Adhesions 9 98.90 Very High Very High Very High
Atherosclerosis 35 98.42 Very High Very High Very High
Complex Regional Pain Syndromes 4 97.04 Very High Very High Very High
Apoptosis 3 96.48 Very High Very High Very High
Rupture 6 93.08 High High
INFLAMMATION 20 91.32 High High
Increased Venous Pressure Under Development 3 89.44 High High
Thrombophilia 2 85.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Tissue factor content is increased in unstable angina and correlates with areas of macrophages and smooth muscle cells, suggesting a cell-mediated thrombogenicity in patients with acute coronary syndromes.


Positive_regulation (increased) of Tissue factor in smooth muscle cells
1) Confidence 0.22 Published 1996 Journal Circulation Section Body Doc Link 8989114 Disease Relevance 0.05 Pain Relevance 0
Tissue factor elevation may be a cause or a consequence of AS inflammation that promotes the occurrence of vascular events.


Positive_regulation (elevation) of Tissue factor
2) Confidence 0.17 Published 2006 Journal Joint Bone Spine Section Body Doc Link 16730212 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Tissue factor content is increased in unstable angina and correlates with areas of macrophages and smooth muscle cells, suggesting a cell-mediated thrombogenicity in patients with acute coronary syndromes.


Positive_regulation (increased) of Tissue factor in macrophages
3) Confidence 0.07 Published 1996 Journal Circulation Section Body Doc Link 8989114 Disease Relevance 0.05 Pain Relevance 0
The tissue factor and prothrombin fragment 1+2 levels before administration were elevated in patients with angina pectoris and were reduced to the levels of chest pain syndrome after the administration.
Positive_regulation (elevated) of tissue factor in chest associated with complex regional pain syndromes and angina
4) Confidence 0.06 Published 1999 Journal Thromb. Res. Section Abstract Doc Link 10065895 Disease Relevance 0.90 Pain Relevance 0.82
In 20%-33% of patients, monocytes expressed high basal levels of IL-8, tissue factor, IL-1beta, and monocyte chemoattractant protein-1 mRNA.
Positive_regulation (levels) of tissue factor in monocyte
5) Confidence 0.01 Published 1999 Journal Exp. Mol. Med. Section Abstract Doc Link 10551265 Disease Relevance 0.85 Pain Relevance 0.52
In cell culture experiments, a wide variety of in vitro atherosclerotic putative triggers (CRP, cholesterol esters, glucose, angiotensin) are able to increase the acivity of tissue factor in cultured macrophages and vascular smooth muscle cells (Cirillo et al 2005), an event prevented by in vitro incubation with anti-atherosclerotic drugs, such as statins (Dietzen et al 2007) and antiplatelet drugs (Camera et al 2003).
Positive_regulation (increase) of tissue factor in macrophages associated with atherosclerosis
6) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721378 Disease Relevance 0.89 Pain Relevance 0.04
Plasma factor VII and thrombin-antithrombin III levels indicate increased tissue factor activity in sickle cell patients.
Positive_regulation (increased) of tissue factor in Plasma associated with sickle cell anemia
7) Confidence 0.01 Published 1992 Journal Br. J. Haematol. Section Title Doc Link 1390242 Disease Relevance 0.73 Pain Relevance 0
They did not express the activation markers intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, and E-selectin, although some were positive for tissue factor.
Positive_regulation (positive) of tissue factor associated with adhesions
8) Confidence 0.01 Published 1999 Journal Blood Section Abstract Doc Link 10216090 Disease Relevance 1.43 Pain Relevance 0.48

General Comments

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