INT91062

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2000
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.49
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm3) signal transducer activity (Grm3)
Anatomy Link Frequency
reticular thalamic nucleus 2
nerve 2
cerebral cortex 2
Grm3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 11 100.00 Very High Very High Very High
Pain 5 100.00 Very High Very High Very High
nociceptor 4 100.00 Very High Very High Very High
Dorsal horn 3 100.00 Very High Very High Very High
cerebral cortex 3 99.68 Very High Very High Very High
Inflammation 4 99.28 Very High Very High Very High
medulla 6 96.64 Very High Very High Very High
agonist 1 94.80 High High
IPN 3 94.00 High High
Spinal nerve ligature 3 85.28 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 99.28 Very High Very High Very High
Nociception 7 96.66 Very High Very High Very High
Disease 5 95.28 Very High Very High Very High
Inflammatory Pain 3 94.00 High High
Arthritis 2 77.48 Quite High
Neuropathic Pain 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present data show an up-regulation of mGluR3 mRNA expression in the motor, somatosensory, and limbic cortices of MA rats.
Positive_regulation (up-regulation) of Gene_expression (expression) of mGluR3 mRNA
1) Confidence 0.69 Published 2001 Journal J. Neurosci. Res. Section Abstract Doc Link 11170186 Disease Relevance 0.22 Pain Relevance 0.16
In contrast, mGluR3 mRNA expression was abundant in normal rats and was significantly increased in cortical areas of MA rats at all time points.
Positive_regulation (increased) of Gene_expression (expression) of mGluR3 mRNA
2) Confidence 0.69 Published 2001 Journal J. Neurosci. Res. Section Abstract Doc Link 11170186 Disease Relevance 0.23 Pain Relevance 0.19
Up-regulation of metabotropic glutamate receptor 3 mRNA expression in the cerebral cortex of monoarthritic rats.
Positive_regulation (Up-regulation) of Gene_expression (expression) of metabotropic glutamate receptor 3 mRNA in cerebral cortex associated with nociceptor, glutamate receptor and cerebral cortex
3) Confidence 0.69 Published 2001 Journal J. Neurosci. Res. Section Title Doc Link 11170186 Disease Relevance 0.17 Pain Relevance 0.44
NAAG is an agonist at the inhibitory metabotropic glutamate receptor mGluR3, and 2-PMPA may inhibit nociceptive transmission in normal animals by elevating synaptic NAAG levels, allowing it to activate mGluR3 and thus reducing transmitter release from afferent nerve terminals. mGluR3 expression in the superficial dorsal horn is upregulated after peripheral inflammation, perhaps explaining the greater inhibition of neuronal responses we observed after carrageenan inflammation.
Positive_regulation (upregulated) of Gene_expression (expression) of mGluR3 in nerve associated with nociception, inflammation, glutamate receptor, dorsal horn and agonist
4) Confidence 0.49 Published 2003 Journal Neuropeptides Section Abstract Doc Link 14607107 Disease Relevance 0.58 Pain Relevance 0.71
Similar decreases of mGluR7 mRNA expression in the VB and Po were found at all time points, while mGluR3 mRNA expression was bilaterally increased in the reticular thalamic nucleus (Rt).
Positive_regulation (increased) of Gene_expression (expression) of mGluR3 mRNA in reticular thalamic nucleus
5) Confidence 0.30 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11000486 Disease Relevance 0.15 Pain Relevance 0.34
The reduced expression of mGluR1, 4 and 7 transcripts in VB and Po, and the increases of mGluR3 mRNA in the Rt may contribute to counteract the increased noxious input arising from the periphery.
Positive_regulation (increases) of Gene_expression (expression) of mGluR3 mRNA
6) Confidence 0.22 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11000486 Disease Relevance 0.14 Pain Relevance 0.30

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox