INT91065

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Context Info
Confidence 0.62
First Reported 2000
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 13
Total Number 23
Disease Relevance 12.48
Pain Relevance 6.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
hippocampus 8
brain 4
neuronal 2
poly 2
spines 2
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 216 100.00 Very High Very High Very High
imagery 37 100.00 Very High Very High Very High
antidepressant 22 100.00 Very High Very High Very High
bDMF 18 100.00 Very High Very High Very High
Nerve growth factor 12 100.00 Very High Very High Very High
peripheral neuropathy 5 99.86 Very High Very High Very High
depression 38 99.76 Very High Very High Very High
dorsal root ganglion 12 99.68 Very High Very High Very High
fluoxetine 17 99.34 Very High Very High Very High
Desipramine 10 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 525 99.98 Very High Very High Very High
Peripheral Neuropathy 5 99.86 Very High Very High Very High
Disease 103 99.84 Very High Very High Very High
Depression 39 99.76 Very High Very High Very High
Ganglion Cysts 12 99.68 Very High Very High Very High
Convulsion 32 98.22 Very High Very High Very High
Anxiety Disorder 217 98.12 Very High Very High Very High
Death 18 97.36 Very High Very High Very High
Mental Disorders 32 97.28 Very High Very High Very High
Frailty 6 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To our knowledge, only 2 studies have examined the regulatory effect of histone acetylation on the expression of BDNF mRNA in the rat hippocampus after an acute stimulation.15,20 In response to pilocarpine-induced status epilepticus, increased levels of exon I and IV of the BDNF gene were, at least in part, derived from the hyperacetylation of histone H4 at the P2 promoter and deacetylation of histone H4 associated with the P4 promoter.20 Likewise, the marked increase in histone H4 acetylation, but not histone H3 acetylation, at the P2 promoter of the BDNF gene correlated with an increase in total BDNF mRNA in the rat hippocampus 2 h after electroconvulsive seizure.15 In contrast with our study, these previous studies indicated the importance of histone H4 acetylation at the P2 promoter in the regulation of BDNF mRNA expression.
Regulation (regulation) of Transcription (expression) of BDNF in hippocampus associated with convulsion, status epilepticus and hippocampus
1) Confidence 0.62 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.63 Pain Relevance 0.09
In summary, the present study demonstrates that stress affects transcription of the BDNF gene via histone acetylation and demethylation.
Regulation (affects) of Transcription (transcription) of BDNF associated with stress
2) Confidence 0.62 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.89 Pain Relevance 0
Dendritic translation of BDNF mRNA can regulate morphological changes in spines [12].
Regulation (regulate) of Transcription (translation) of BDNF in spines
3) Confidence 0.59 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.57 Pain Relevance 0
These findings suggest that changes in BDNF transcription in the rat hippocampus in response to stressful stimuli are, at least in part, regulated by histone acetylation status.



Regulation (changes) of Transcription (transcription) of BDNF in hippocampus associated with hippocampus
4) Confidence 0.54 Published 2010 Journal Psychiatry Investigation Section Abstract Doc Link PMC3022311 Disease Relevance 0.63 Pain Relevance 0.09
Although L5SSNL increased significantly (P<0.05) the expression of total BDNF mRNA and exon IIC and IXA transcripts in the contralateral L4/5 DRGs, CFA treatment did not alter the expression of total BDNF mRNA or specific transcripts in the contralateral DRGs.
Neg (not) Regulation (alter) of Transcription (expression) of BDNF mRNA
5) Confidence 0.45 Published 2008 Journal Brain Res. Section Abstract Doc Link 18353280 Disease Relevance 0.49 Pain Relevance 0.44
Because BDNF levels are reduced in the brains of HD patients and HD mouse models, we sought to investigate whether Htt might be involved in the transport of BDNF mRNA through neuronal RNA granules.
Spec (might) Regulation (involved) of Transcription (transport) of BDNF in neuronal associated with disease
6) Confidence 0.43 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.20 Pain Relevance 0
To extend these findings, the expression of BDNF mRNA was analyzed with Htt and CPEB1, a protein responsible for recognition of cytoplasmic polyadenylation elements (CPEs) and regulating poly (A) length.
Spec (analyzed) Regulation (analyzed) of Spec (analyzed) Transcription (expression) of BDNF in poly
7) Confidence 0.43 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
For imaging of BDNF mRNA in live cells, 0.33 ?
Regulation (0.33) of Transcription (imaging) of BDNF associated with imagery
8) Confidence 0.43 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.07 Pain Relevance 0.14
In the PFC, a significant effect of Exploration was revealed on the BDNF mRNA levels normalized with ?
Regulation (normalized) of Transcription (levels) of BDNF
9) Confidence 0.43 Published 2008 Journal Brain Res Section Body Doc Link PMC2568862 Disease Relevance 0.05 Pain Relevance 0.09
To elucidate the mechanism by which transcription of the BDNF gene is affected in response to FC in SPS rats, we evaluated hippocampal total histone acetylation by western blotting, and histone acetylation levels at each promoter of the BDNF gene in the hippocampus was measured by ChIP assay followed by RT-PCR.
Regulation (affected) of Transcription (transcription) of BDNF in hippocampus associated with stress and hippocampus
10) Confidence 0.27 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 1.12 Pain Relevance 0.14
Stress exposure is well known to lead to the onset of stress-related mental disorders such as major depression and posttraumatic stress disorder (PTSD).8-10 Although changes in gene expression under stressful condition have been reported, the precise mechanisms by which stress affects gene transcription are not fully understood.8 With regard to the pathogenesis of major depression, a series of studies showed that BDNF was closely involved in the pathophysiological and therapeutic mechanisms of this stress-related disorder.11 In fact, several studies reported that acute restraint or immobilization stress decreased the expression of BDNF in the rodent brain.12-14 Recent studies have demonstrated epigenetic regulation of BDNF gene transcription in response to external stimuli such as social defeat stress and electroconvulsive seizures.7,15 Further studies to elucidate the epigenetic regulatory mechanism of stress-induced changes in BDNF gene transcription may provide new insight into the pathophysiology of stress-related mental disorders.
Regulation (regulation) of Transcription (transcription) of BDNF in brain associated with mental disorders, stress, convulsion, post-traumatic stress disorder and depression
11) Confidence 0.27 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 1.69 Pain Relevance 0.15
Stress exposure is well known to lead to the onset of stress-related mental disorders such as major depression and posttraumatic stress disorder (PTSD).8-10 Although changes in gene expression under stressful condition have been reported, the precise mechanisms by which stress affects gene transcription are not fully understood.8 With regard to the pathogenesis of major depression, a series of studies showed that BDNF was closely involved in the pathophysiological and therapeutic mechanisms of this stress-related disorder.11 In fact, several studies reported that acute restraint or immobilization stress decreased the expression of BDNF in the rodent brain.12-14 Recent studies have demonstrated epigenetic regulation of BDNF gene transcription in response to external stimuli such as social defeat stress and electroconvulsive seizures.7,15 Further studies to elucidate the epigenetic regulatory mechanism of stress-induced changes in BDNF gene transcription may provide new insight into the pathophysiology of stress-related mental disorders.
Regulation (changes) of Transcription (transcription) of BDNF in brain associated with mental disorders, stress, convulsion, post-traumatic stress disorder and depression
12) Confidence 0.27 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 1.64 Pain Relevance 0.15
After a single injection the down-regulation was detected at 4 h (TCP, fluoxetine, paroxetine and sertraline) but BDNF mRNA levels were not altered at 24 h post drug (TCP, fluoxetine and paroxetine).
Neg (not) Regulation (altered) of Transcription (levels) of BDNF associated with bdmf and fluoxetine
13) Confidence 0.27 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12726822 Disease Relevance 0 Pain Relevance 1.26
Administration of inhibitors of noradrenaline re-uptake (desipramine and maprotiline) or the atypical antidepressant mianserin had no effect on BDNF mRNA levels at either single (4 h post drug, desipramine) or repeated (24 h post drug, desipramine, maprotiline, mianserin) treatment.
Neg (no) Regulation (effect) of Transcription (levels) of BDNF associated with antidepressant, desipramine, noradrenaline and bdmf
14) Confidence 0.27 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12726822 Disease Relevance 0 Pain Relevance 1.32
The temporal pattern of BDNF mRNA expression in the DRG was similar to BDNF-immunoreactivity.
Regulation (pattern) of Transcription (expression) of BDNF in DRG associated with dorsal root ganglion
15) Confidence 0.27 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11000490 Disease Relevance 0.43 Pain Relevance 0.70
The effect by antidepressant drugs on BDNF mRNA expression is, however, strictly dependent on both treatment duration and time after the last administration.
Regulation (dependent) of Transcription (expression) of BDNF associated with antidepressant
16) Confidence 0.27 Published 2006 Journal Brain Res. Section Abstract Doc Link 16842762 Disease Relevance 0.10 Pain Relevance 0.17
The effect by antidepressant drugs on BDNF mRNA expression is, however, strictly dependent on both treatment duration and time after the last administration.
Regulation (effect) of Transcription (expression) of BDNF associated with antidepressant
17) Confidence 0.27 Published 2006 Journal Brain Res. Section Abstract Doc Link 16842762 Disease Relevance 0.10 Pain Relevance 0.17
Transcription of BDNF is reported deregulated in HD, and transport of BDNF secretory vesicles necessary for neuronal survival requires a functional Htt [7,8].
Regulation (deregulated) of Transcription (Transcription) of BDNF in vesicles associated with disease
18) Confidence 0.26 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.84 Pain Relevance 0.03
In addition to axonal transport of BDNF, transcription of the BDNF gene was also reported deregulated in Huntington's disease [7,8].
Regulation (deregulated) of Transcription (transcription) of BDNF gene associated with disease
19) Confidence 0.26 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.65 Pain Relevance 0
Moreover, three injections (3×) evoked similar diminishing effects on hippocampal BDNF mRNA levels as those observed at earlier time points.


Regulation (effects) of Transcription (levels) of BDNF
20) Confidence 0.26 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.23 Pain Relevance 0.40

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