INT91070

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Context Info
Confidence 0.59
First Reported 2000
Last Reported 2010
Negated 9
Speculated 3
Reported most in Body
Documents 27
Total Number 31
Disease Relevance 16.64
Pain Relevance 3.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSR) mitochondrion (GSR) small molecule metabolic process (GSR)
oxidoreductase activity (GSR) cytoplasm (GSR)
Anatomy Link Frequency
macrophages 1
monocytes 1
erythrocytes 1
facets 1
brain 1
GSR (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 41 99.90 Very High Very High Very High
Paracetamol 169 99.60 Very High Very High Very High
Hippocampus 32 99.20 Very High Very High Very High
Inflammation 80 98.68 Very High Very High Very High
dexamethasone 37 98.00 Very High Very High Very High
aspirin 50 94.24 High High
withdrawal 1 84.48 Quite High
ischemia 40 83.92 Quite High
depression 33 80.16 Quite High
imagery 22 75.12 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 92 100.00 Very High Very High Very High
Skin Cancer 52 100.00 Very High Very High Very High
Gingival Recession 7 100.00 Very High Very High Very High
Stress 312 99.70 Very High Very High Very High
Stroke 128 99.64 Very High Very High Very High
Asthma 13 99.60 Very High Very High Very High
Cataract 99 98.80 Very High Very High Very High
INFLAMMATION 96 98.68 Very High Very High Very High
Diabetes Mellitus 85 98.62 Very High Very High Very High
Urological Neuroanatomy 22 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The normal dex/CRH response in patients with high levels of emotional neglect suggests that emotional neglect in childhood either does not influence GR function or up-regulates GR function (most probably via persistent hypo-thalamic drive), offsetting the genetically induced GR down regulation seen in many bipolar patients and producing a null effect.
Spec (probably) Regulation (regulates) of GR
1) Confidence 0.59 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.49 Pain Relevance 0
In their experiment they calculated mean GSR values for a computer game played over several minutes.
Regulation (values) of GSR
2) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2517650 Disease Relevance 0.13 Pain Relevance 0.17
KA, DKC and GR were also involved in the preparation of manuscript.
Regulation (involved) of GR
3) Confidence 0.40 Published 2010 Journal J Ethnobiol Ethnomed Section Body Doc Link PMC2843656 Disease Relevance 0.05 Pain Relevance 0
The normal dex/CRH response in patients with high levels of emotional neglect suggests that emotional neglect in childhood either does not influence GR function or up-regulates GR function (most probably via persistent hypo-thalamic drive), offsetting the genetically induced GR down regulation seen in many bipolar patients and producing a null effect.
Neg (not) Regulation (influence) of GR
4) Confidence 0.26 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.49 Pain Relevance 0
Such tests are more sensitive as they assess facets of the HPA axis which are considered to be primary causal factors, namely dysregulation of hypothalamic drive (Holsboer 2002) and reduced glucocorticoid receptor (GR) feedback (McQuade and Young 2000; Pariante and Miller 2001).
Regulation (dysregulation) of GR in facets
5) Confidence 0.26 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.54 Pain Relevance 0.13
The normal dex/CRH response in patients with high levels of emotional neglect suggests that emotional neglect in childhood either does not influence GR function or up-regulates GR function (most probably via persistent hypo-thalamic drive), offsetting the genetically induced GR down regulation seen in many bipolar patients and producing a null effect.
Regulation (regulation) of GR
6) Confidence 0.26 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.59 Pain Relevance 0
Fructose infusion doubled UDPG turnover, but there was no effect on TGO, GC, NEGP, or GR(d) under hyperglycemic pancreatic clamp protocol conditions.
Neg (no) Regulation (effect) of GR
7) Confidence 0.24 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 11001775 Disease Relevance 0.10 Pain Relevance 0.09
At the same time, we found that the extract had no effect on the activities of GPx and GR.
Neg (no) Regulation (effect) of GR
8) Confidence 0.24 Published 2010 Journal Advances in Pharmacological Sciences Section Body Doc Link PMC3005810 Disease Relevance 0 Pain Relevance 0
In view of our findings that the extract had no effect on the activities of GPx and GR reductase, we suggest that T.
Neg (no) Regulation (effect) of GR reductase
9) Confidence 0.24 Published 2010 Journal Advances in Pharmacological Sciences Section Body Doc Link PMC3005810 Disease Relevance 0 Pain Relevance 0
One important finding in the present study is the minimal change or even improved GR values following the employed surgical technique.
Regulation (values) of GR associated with gingival recession
10) Confidence 0.22 Published 2008 Journal Clin Oral Investig Section Body Doc Link PMC2491434 Disease Relevance 0.34 Pain Relevance 0
will eventually help to determine if there is role for GR?
Regulation (role) of GR
11) Confidence 0.17 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.65 Pain Relevance 0.13
Since GC therapy represents a treatment option for clinical stroke to contain inflammatory processes, the investigation of the role of stress and lesion in GR regulation is critical to explore future therapeutic avenues.
Regulation (regulation) of GR associated with stress, inflammation and stroke
12) Confidence 0.16 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2954925 Disease Relevance 0.86 Pain Relevance 0.05
Studies have shown that cytokines may alter the GR function in various cell types, including T cells [54], monocytes/macrophages [55], bronchial lung [53] and liver [55] cells.
Spec (may) Regulation (alter) of GR in macrophages associated with cytokine
13) Confidence 0.15 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.83 Pain Relevance 0.23
A corollary of elevated glucocorticoids and compromised hippocampal functioning may also be the down-regulation of the GR sensitivity.
Regulation (regulation) of GR
14) Confidence 0.14 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228409 Disease Relevance 0.72 Pain Relevance 0.23
Our findings indicated that the conversion of Gr to UA through G and Xan intermediates was affected by the antipsychotic drugs, consistent with our data that significant product-precursor correlations between UA and Gr, and between G and Gr were disrupted after 4-w treatment of antipsychotic treatment (Figure 5).
Regulation (affected) of Gr
15) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2831068 Disease Relevance 0.13 Pain Relevance 0.04
In this case, the greatest dynamics are fixed in a change in the levels of glutathione reductase (GR) and of catalase (CAT) in basic groups to 12%, 47%, 42%, 21% and 11%, 26%, 8%, 37%, and in the patients of the group of comparison to 10% and 23%, accordingly.


Regulation (change) of GR
16) Confidence 0.13 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC1779269 Disease Relevance 0.35 Pain Relevance 0
In this case, the greatest dynamics are fixed in a change in the levels of glutathione reductase (GR) and of catalase (CAT) in basic groups to 12%, 47%, 42%, 21% and 11%, 26%, 8%, 37%, and in the patients of the group of comparison to 10% and 23%, accordingly.


Regulation (change) of glutathione reductase
17) Confidence 0.13 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC1779269 Disease Relevance 0.35 Pain Relevance 0
Two of the main mechanisms for resistance to glucocorticoid apoptosis are defects in the GR signaling and/or defects of the cell apoptotic machinery, such as disregulation of the Bcl-2 rheostat [13].
Regulation (disregulation) of GR associated with apoptosis
18) Confidence 0.12 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656252 Disease Relevance 0.85 Pain Relevance 0.09
The dose-dependent effects on three melanoma cell lines (WM, GR, PNP) and on normal fibroblasts short term culture (as control) were tested using S7 racemic mixture, S7-(R) and S7-(S).
Regulation (effects) of GR in fibroblasts associated with skin cancer
19) Confidence 0.10 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1785384 Disease Relevance 0.51 Pain Relevance 0
As shown in Figures 5, 6, 7, a toxic dose of APAP exerted a lowering effect on the hepatic activities of GR, GST and GCS.
Regulation (effect) of GR associated with paracetamol
20) Confidence 0.09 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0 Pain Relevance 0.60

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