INT91075

Context Info Confidence 0.54 First Reported 2000 Last Reported 2000 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.10 Pain Relevance 0.60

extracellular space (NPTXR) nucleus (BHLHE22) plasma membrane (NPTXR)

Anatomy Link Frequency muscle cells 1 NPTXR (Homo sapiens) BHLHE22 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 1 99.04 Somatostatin 2 96.60 Enkephalin 1 95.44 Kinase C 7 93.16 adenocard 1 79.44 opioid receptor 1 77.04 Cholecystokinin 1 65.68

Disease Link Frequency Relevance Heat Natriuresis 1 99.42

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Pretreatment of muscle cells with cANP-(4-23), a selective agonist of the natriuretic peptide clearance receptor, NPR-C, which activates phospholipase C (PLC)-beta3 via the betagamma-subunits of G(i-1) and G(i-2), inhibited the PLC-beta response to somatostatin and [D-Pen(2,5)]enkephalin.

NPR Positive_regulation (activates) of beta3 in muscle cells associated with natriuresis, somatostatin, agonist and enkephalin

1) Confidence 0.54 Published 2000 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 11003572 Disease Relevance 0.10 Pain Relevance 0.60

General Comments

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