INT9110

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Context Info
Confidence 0.41
First Reported 1992
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 32
Total Number 33
Disease Relevance 42.10
Pain Relevance 3.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PAH) small molecule metabolic process (PAH) cellular nitrogen compound metabolic process (PAH)
Anatomy Link Frequency
connective tissue 5
vascular system 1
liver 1
amacrine cells 1
lung 1
PAH (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 41 100.00 Very High Very High Very High
fibrosis 151 99.98 Very High Very High Very High
noradrenaline 16 99.64 Very High Very High Very High
ischemia 40 99.08 Very High Very High Very High
Catecholamine 124 98.40 Very High Very High Very High
Neuropeptide 8 97.56 Very High Very High Very High
Serotonin 10 97.36 Very High Very High Very High
headache 53 97.16 Very High Very High Very High
palliative 5 96.32 Very High Very High Very High
fluoxetine 1 90.12 High High
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 1551 100.00 Very High Very High Very High
Disease 409 100.00 Very High Very High Very High
Hypertension 315 100.00 Very High Very High Very High
Pressure And Volume Under Development 310 100.00 Very High Very High Very High
Pheochromocytoma 200 100.00 Very High Very High Very High
Anxiety Disorder 47 100.00 Very High Very High Very High
Depression 41 100.00 Very High Very High Very High
Pulmonary Fibrosis 94 99.98 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 67 99.98 Very High Very High Very High
Hypersensitivity Vasculitis 14 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hemolysis associated PAH
PAH Binding (associated) of associated with pulmonary hypertension and hemolysis
1) Confidence 0.41 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994020 Disease Relevance 1.50 Pain Relevance 0.07
Further testing is directed at evaluating specific conditions associated with PAH and excluding secondary causes of pulmonary hypertension.9,10 Chest radiography may reveal enlarged pulmonary arteries and right heart structures.
PAH Binding (associated) of in heart associated with pulmonary hypertension
2) Confidence 0.36 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC3004515 Disease Relevance 1.05 Pain Relevance 0
A 41-year-old woman with a 15-year history of PAH associated with a corrected atrial septal defect presented with severe deterioration of symptoms.
PAH Binding (associated) of associated with pulmonary hypertension and cv general 2 under development
3) Confidence 0.36 Published 2008 Journal Chest Section Abstract Doc Link 18187754 Disease Relevance 0.73 Pain Relevance 0.12
Fibrotic lung disease is frequently associated with PH and can be a source of significant morbidity and mortality (King et al 2001).
PH Binding (associated) of in lung associated with fibrosis, pulmonary hypertension and pulmonary disease
4) Confidence 0.32 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994020 Disease Relevance 1.27 Pain Relevance 0.18
Altitude-associated PH
PH Binding (associated) of associated with pulmonary hypertension
5) Confidence 0.32 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994020 Disease Relevance 1.13 Pain Relevance 0.08
The only comparative treatment trial studied patients with idiopathic or collagen vascular disease associated PAH who were symptomatic despite maximal conventional therapy.
PAH Binding (associated) of associated with pulmonary hypertension and hypersensitivity vasculitis
6) Confidence 0.32 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994020 Disease Relevance 0.69 Pain Relevance 0
Cognitive impairments and their associations with depression, anxiety, and quality of life in patients with PAH have not been described.
PAH Neg (impairments) Binding (associations) of associated with pulmonary hypertension, cognitive disorder, depression and anxiety disorder
7) Confidence 0.31 Published 2006 Journal Respir Res Section Body Doc Link PMC1448205 Disease Relevance 2.10 Pain Relevance 0.24
Pulmonary fibrosis associated PH
PH Binding (associated) of associated with fibrosis, pulmonary hypertension and pulmonary fibrosis
8) Confidence 0.28 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994020 Disease Relevance 1.27 Pain Relevance 0.19
PAH can be idiopathic, familial, or secondary to a variety of conditions such as connective tissue disease, hemoglobinopathies, or HIV infection (Table 1).
PAH Binding (secondary) of in connective tissue associated with hemoglobinopathy, pulmonary hypertension, acquired immune deficiency syndrome or hiv infection, disease and infection
9) Confidence 0.28 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994020 Disease Relevance 1.65 Pain Relevance 0.03
HIV-associated PAH
PAH Binding (associated) of associated with pulmonary hypertension and acquired immune deficiency syndrome or hiv infection
10) Confidence 0.28 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994020 Disease Relevance 1.20 Pain Relevance 0.04
Patients with idiopathic, familial, HIV, anorexigen, connective tissue disease and congenital heart disease (with some restrictions) associated PAH were recruited.36 Rather than fixing an absolute upper limit for the baseline 6MWD a value of less than 80% predicted or 500 m with a Borg score ?
PAH Binding (associated) of in upper associated with pulmonary hypertension, cv general 4 under development, acquired immune deficiency syndrome or hiv infection and disease
11) Confidence 0.28 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2725793 Disease Relevance 0.79 Pain Relevance 0.04
Patients with chronic thrombo-embolic disease not amenable to surgery can be considered for treatment with specific PAH therapies.15 Detailed discussion of the differences between various subgroups and the formulation of treatment algorithms is beyond the scope of this review, and further information can be found in other articles.1,6,16
PAH Binding (specific) of associated with pulmonary hypertension, embolism and disease
12) Confidence 0.28 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2725793 Disease Relevance 1.52 Pain Relevance 0.12
The BREATHE-4 study demonstrated benefit in 16 patients with HIV associated PAH.
PAH Binding (associated) of associated with pulmonary hypertension and acquired immune deficiency syndrome or hiv infection
13) Confidence 0.27 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2725793 Disease Relevance 0.94 Pain Relevance 0
The hypertension associated with PH is primarily due to increased total peripheral resistance.
PH Binding (associated) of associated with hypertension and pheochromocytoma
14) Confidence 0.19 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 0.94 Pain Relevance 0.17
Biochemical investigation for PH/PGL is generally confined to hypertensive patients reporting bouts of headaches, palpitations and sweating, those with hypertension resistant to treatment, and those with incidentalomas or with a familial disease that predisposes to PH and/or PGL.
PH Binding (investigation) of associated with heart rate under development, hypertension, paraganglioma, headache, disease and pheochromocytoma
15) Confidence 0.19 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 1.56 Pain Relevance 0.53
The mechanism of this increase in resistance would seem to be straightforward because noradrenaline, secreted by the majority of PH, is a potent vasoconstrictor through stimulation of ?
PH Binding (majority) of associated with noradrenaline and pheochromocytoma
16) Confidence 0.19 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 0.95 Pain Relevance 0.29
Data from subgroup analyses did not exhibit a clinically relevant treatment effect in patients with PAH associated with CHD.70 In contrast, the subgroup of patients with PAH associated with connective tissue disease (CTD) showed an increased 6MWD with sitaxentan treatment.82,83


PAH Binding (associated) of in connective tissue associated with pulmonary hypertension, disease and coronary heart disease
17) Confidence 0.19 Published 2008 Journal European Heart Journal Section Body Doc Link PMC2515885 Disease Relevance 0.76 Pain Relevance 0
Presymptomatic diagnosis is also possible in patients with phenotypic evidence or a family history of a genetic disease that is associated with PH/PGL (see below).


PH Binding (associated) of associated with paraganglioma, disease and pheochromocytoma
18) Confidence 0.18 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 1.89 Pain Relevance 0.10
Of the wide spectrum of diseases encompassed by the term ‘pulmonary hypertension’, PAH with associated CTD (PAH-CTD) is a disease for which patients have a particularly poor prognosis.
PAH Binding (associated) of associated with pulmonary hypertension and disease
19) Confidence 0.17 Published 2008 Journal European Heart Journal Section Body Doc Link PMC2515885 Disease Relevance 1.34 Pain Relevance 0
Data from subgroup analyses did not exhibit a clinically relevant treatment effect in patients with PAH associated with CHD.70 In contrast, the subgroup of patients with PAH associated with connective tissue disease (CTD) showed an increased 6MWD with sitaxentan treatment.82,83


PAH Binding (associated) of in connective tissue associated with pulmonary hypertension, disease and coronary heart disease
20) Confidence 0.15 Published 2008 Journal European Heart Journal Section Body Doc Link PMC2515885 Disease Relevance 0.77 Pain Relevance 0

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