INT91106

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Context Info
Confidence 0.51
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 5.73
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (LTF) extracellular region (LTF) cytoplasm (LTF)
Anatomy Link Frequency
parasympathetic 1
T-cell 1
LTF (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 8 99.72 Very High Very High Very High
depression 56 87.80 High High
rapifen 2 79.48 Quite High
medulla 50 79.16 Quite High
agonist 1 67.44 Quite High
spastic colon 25 65.56 Quite High
Inflammation 35 50.00 Quite Low
reflex sympathetic dystrophy 5 50.00 Quite Low
Inflammatory mediators 1 50.00 Quite Low
anesthesia 1 39.04 Quite Low
Disease Link Frequency Relevance Heat
Lymphatic Filariasis 267 100.00 Very High Very High Very High
Infection 59 99.96 Very High Very High Very High
Disease 281 99.04 Very High Very High Very High
Lymphedema 84 99.00 Very High Very High Very High
Hydrocele 78 98.40 Very High Very High Very High
Recurrence 9 97.88 Very High Very High Very High
Inflammatory Bowel Disease 118 94.72 High High
Dystonia 2 94.32 High High
Complex Regional Pain Syndromes 5 93.40 High High
Stress 8 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In awake subjects, clonidine (2.25 ng/mL) decreased LTF by 14%+/-13% and SBP from 141+/-7 to 110+/-15 mm Hg (P<0.0001).
Negative_regulation (decreased) of LTF associated with clonidine
1) Confidence 0.51 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 11004028 Disease Relevance 0.37 Pain Relevance 0.73
Therefore, LF was expected to be lost during protein precipitation.
Negative_regulation (lost) of LF
2) Confidence 0.33 Published 2010 Journal Analytical Chemistry Insights Section Body Doc Link PMC2865164 Disease Relevance 0 Pain Relevance 0
As a result, it was concluded that the determination of fecal calprotectin and lactoferrin might be useful in predicting an impending clinical relapse, especially during the following 3 months of remission, in both CD and UC patients.51
Negative_regulation (determination) of lactoferrin associated with inflammatory bowel disease, disease and recurrence
3) Confidence 0.09 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.57 Pain Relevance 0.18
Indirect productivity loss due to clinical LF
Negative_regulation (loss) of LF associated with lymphatic filariasis
4) Confidence 0.08 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 0.71 Pain Relevance 0
Economic benefits to national health systems resulting from reduced LF infections derive particularly from patient service costs averted in the public sector.
Negative_regulation (reduced) of LF associated with lymphatic filariasis and infection
5) Confidence 0.08 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 0.51 Pain Relevance 0
The prevention of LF infection and clinical disease has led to additional benefits that are difficult or impossible to quantify in monetary terms.
Negative_regulation (prevention) of LF associated with lymphatic filariasis, disease and infection
6) Confidence 0.08 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 1.22 Pain Relevance 0
We measured interleukin-1beta, interleukin-6, interferon-gamma inducible protein-10, RANTES (regulated upon activation, normal T-cell expressed and secreted), complement C3, mannose-binding lectin, complement C1q, soluble intercellular adhesion molecule-1, endothelin-1, nitric oxide, human lactoferrin, and hypocretin-1 levels in these samples.
Negative_regulation (measured) of lactoferrin in T-cell
7) Confidence 0.07 Published 2008 Journal Clin J Pain Section Body Doc Link 18180633 Disease Relevance 0.19 Pain Relevance 0
The separate GEE models disclosed a decrease in both the LF nu-RRI and HF nu-RRI variability exclusively in the cathodal group; this was reflected in the fact that the analysis of the percentage of variance outside the mean ± 1.96 SD also showed a difference for the PSD-RRI for the cathodal group only.
Negative_regulation (decrease) of LF nu-RRI
8) Confidence 0.04 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844382 Disease Relevance 0.15 Pain Relevance 0.10
In independent experiments, we evaluated the dose-dependent effects of lactoferrin (1, 10, and 100 ?
Negative_regulation (effects) of lactoferrin
9) Confidence 0.04 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.19 Pain Relevance 0
Since the baseline SD values of the LF nu-RRI and HF nu-RRI were statistically different, separate GEE models were computed for each group; these separate GEE models showed no significant effect for the sham and anodal groups (p > 0.277) but showed a significant decrease (increase) of the SD values for the LF nu-RRI (HF nu-RRI) over time for the cathodal group only (p = 0.044).
Negative_regulation (decrease) of LF nu-RRI
10) Confidence 0.03 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844382 Disease Relevance 0.13 Pain Relevance 0
The reduction in LF-HRV, however, was not coupled with an increase in HF-HRV, suggesting inadequate cardiac parasympathetic modulation.
Negative_regulation (reduction) of LF-HRV in parasympathetic
11) Confidence 0.01 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2176141 Disease Relevance 0.50 Pain Relevance 0.08

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