INT91159

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Context Info
Confidence 0.44
First Reported 2000
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 35
Total Number 38
Disease Relevance 26.12
Pain Relevance 5.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) plasma membrane (Ros1)
Anatomy Link Frequency
microglia 2
sciatic nerve 1
lens 1
T cell 1
Ros1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 327 100.00 Very High Very High Very High
cytokine 151 100.00 Very High Very High Very High
Sciatic nerve 8 100.00 Very High Very High Very High
qutenza 10 99.84 Very High Very High Very High
ischemia 212 98.68 Very High Very High Very High
B1 receptor 97 98.52 Very High Very High Very High
rheumatoid arthritis 83 96.60 Very High Very High Very High
agonist 46 94.88 High High
Arthritis 311 94.32 High High
Spinal cord 32 93.68 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 386 100.00 Very High Very High Very High
Parkinson's Disease 22 99.78 Very High Very High Very High
Death 134 99.62 Very High Very High Very High
Myocardial Infarction 49 99.36 Very High Very High Very High
Necrosis 85 99.30 Very High Very High Very High
Increased Venous Pressure Under Development 84 99.30 Very High Very High Very High
Toxicity 63 99.20 Very High Very High Very High
Reperfusion Injury 62 99.00 Very High Very High Very High
Injury 109 98.96 Very High Very High Very High
Stress 339 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on the previous in vitro studies showing inhibition of the ROS induced damage to the lens by caffeine [23,24], these levels were considered adequate for judging its effectiveness in inhibiting the cataract formation.
Negative_regulation (inhibition) of ROS in lens associated with cataract
1) Confidence 0.44 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3002968 Disease Relevance 0.22 Pain Relevance 0.08
Furthermore, these events are dependent on increased ROS generation and, possibly, a subsequent decrease in tissue NO levels during systemic hypoxia.
Spec (possibly) Negative_regulation (decrease) of ROS associated with hypoxia
2) Confidence 0.38 Published 2000 Journal J. Appl. Physiol. Section Abstract Doc Link 11007596 Disease Relevance 0.72 Pain Relevance 0.09
However, ROS are formed in excessive amounts within the first few minutes following reperfusion and are considered a major factor involved in myocardial reperfusion injury.5)21-23) To minimize reperfusion injury, powerful antioxidants have been administered to reduce ROS generation and thereby decrease myocardial injury.17)24)25) Among the antioxidants, ALA, a thiol compound, is a cofactor for mitochondrial dehydration enzymes.
Negative_regulation (reduce) of ROS associated with reperfusion injury, myocardial reperfusion injury, volume depletion and dehydration and injury
3) Confidence 0.31 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771824 Disease Relevance 1.90 Pain Relevance 0.21
As such, a more effective approach is to enhance mitochondrial metabolism by reducing electron leakage with attendant reduction of ROS generation [4].
Negative_regulation (reduction) of ROS
4) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858081 Disease Relevance 0.58 Pain Relevance 0.04
ROS levels increased 2-fold at 30 min after tetracaine treatment compared with the control and then decreased.
Negative_regulation (decreased) of ROS
5) Confidence 0.26 Published 2009 Journal Br J Anaesth Section Body Doc Link 19720611 Disease Relevance 0 Pain Relevance 0
The ROS generation was significantly suppressed (p<0.0001), the activity of pERK 1/2 was significantly increased (p<0.05) and the activity of pJNK 1/2 was significantly decreased (p<0.05) in the ALA 25 mg/kg group compared to the controls.


Negative_regulation (suppressed) of ROS
6) Confidence 0.23 Published 2009 Journal Korean Circulation Journal Section Abstract Doc Link PMC2771824 Disease Relevance 0.37 Pain Relevance 0
On polarized light microscopy, using a detector for active oxygen, CM-H2DCFDA, in the ALA 25 mg/kg group compared to the control group, showed that the generation of ROS was significantly suppressed at the site of myocardial infarction (p<0.0001).
Negative_regulation (suppressed) of ROS associated with myocardial infarction
7) Confidence 0.23 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771824 Disease Relevance 0.82 Pain Relevance 0.15
As such, a more effective approach is to enhance mitochondrial metabolism by reducing electron leakage with attendant reduction of ROS generation.
Negative_regulation (reduction) of ROS
8) Confidence 0.21 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2858081 Disease Relevance 0.37 Pain Relevance 0
ACh-mediated vasodilation responses in arteries from HFD rats were greatly attenuated across a broad range of ACh doses and were normalized by the inhibition of ROS using either tiron and catalase or EUK-134 (Figure 5).
Negative_regulation (inhibition) of ROS associated with increased venous pressure under development
9) Confidence 0.18 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2887873 Disease Relevance 1.11 Pain Relevance 0.04
This finding was surprising because free radicals have generally been associated with inflammation and long-term damage to cells, so that a reduction in ROS might have been expected to decrease susceptibility to an inflammatory disease like RA.


Negative_regulation (reduction) of ROS associated with inflammation, rheumatoid arthritis and disease
10) Confidence 0.17 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1564167 Disease Relevance 1.61 Pain Relevance 0.59
These effects of alagebrium were mediated by inhibition of ERK signaling and down-regulation of COX-2 mRNA expression via reduction of intracellular ROS levels that had been induced by AGE.
Negative_regulation (reduction) of ROS
11) Confidence 0.13 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 1.43 Pain Relevance 0.03
A complete lack of ROS due to Ncf1 deficiency results in chronic granulomatous disease in both mice [33] and humans.
Negative_regulation (lack) of ROS associated with neutrophil disorders
12) Confidence 0.12 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1564167 Disease Relevance 1.48 Pain Relevance 0.50
The increase in T cell oxidative burst could be a reflection of contaminating ROS from granulocytes.
Negative_regulation (reflection) of ROS in T cell
13) Confidence 0.12 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1564167 Disease Relevance 0.18 Pain Relevance 0.04
The increased level in biofluid could be useful to eliminate ROS and can reduce the toxicity of DOX.
Negative_regulation (eliminate) of ROS associated with toxicity
14) Confidence 0.10 Published 2009 Journal Metabolomics Section Body Doc Link PMC2794350 Disease Relevance 0.63 Pain Relevance 0.03
Intracellular levels of reactive oxygen species (ROS), which were greatly increased after H/R, were significantly inhibited by capsaicin, pyrrolidine dithiocarbamate (PDTC) (50 micromol/L), and LY294002.
Negative_regulation (inhibited) of ROS associated with qutenza
15) Confidence 0.10 Published 2008 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 19011674 Disease Relevance 0.70 Pain Relevance 0.61
[45,46]) act to downregulate the principal ROS-scavenging enzymes via increased activity of mitogen-activated protein kinases (47).
Negative_regulation (downregulate) of ROS-scavenging
16) Confidence 0.08 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 1.07 Pain Relevance 0.13
In a trial with type-2 diabetic rats, Bagi et al demonstrated that treatment with rosiglitazone reduced NAD(P)H-derived ROS and increased the activity of catalase [66].
Negative_regulation (reduced) of ROS associated with diabetes mellitus
17) Confidence 0.07 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1131912 Disease Relevance 0.81 Pain Relevance 0.03
Oxidative stress is defined in general as excess formation and/or insufficient removal of highly reactive molecules such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) [8,9].
Negative_regulation (removal) of ROS associated with stress
18) Confidence 0.07 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1131912 Disease Relevance 1.11 Pain Relevance 0
Indeed, lead-chelation therapy might reduce the levels of ROS, associated to NO inactivation, and thus enhance the availability of vascular NO, potentially improving renal function and reducing hypertension [4-6].
Spec (might) Negative_regulation (reduce) of ROS associated with hypertension
19) Confidence 0.07 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1501003 Disease Relevance 0.71 Pain Relevance 0.11
The mechanism by which HO-1 is involved in increased adiponectin levels is related to the function of HO-1 as a stress response/chaperone protein as well as its ability to decrease ROS by increasing glutathione and EC-SOD levels [5, 15, 25] and by decreasing O2?
Negative_regulation (decrease) of ROS associated with stress
20) Confidence 0.04 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635644 Disease Relevance 0.66 Pain Relevance 0.20

General Comments

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