INT91172

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Context Info
Confidence 0.38
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.83
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pdgfrb) plasma membrane (Pdgfrb) nucleus (Pdgfrb)
kinase activity (Pdgfrb) lysosome (Pdgfrb) cytoplasm (Pdgfrb)
Anatomy Link Frequency
platelet 2
Atlas 2
Pdgfrb (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 7 98.20 Very High Very High Very High
imagery 21 97.84 Very High Very High Very High
anesthesia 1 82.08 Quite High
isoflurane 2 80.88 Quite High
Hippocampus 2 75.92 Quite High
Kinase C 1 72.84 Quite High
antagonist 2 68.96 Quite High
cytokine 16 48.24 Quite Low
adenocard 1 38.48 Quite Low
Enkephalin 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 4 100.00 Very High Very High Very High
Targeted Disruption 3 99.88 Very High Very High Very High
Stomach Cancer 58 99.84 Very High Very High Very High
Glioma 9 99.64 Very High Very High Very High
Renal Cell Carcinoma 50 98.80 Very High Very High Very High
Malignant Neoplastic Disease 13 98.72 Very High Very High Very High
Brain Tumor 4 98.48 Very High Very High Very High
Cancer 135 92.64 High High
Genetic Translocation 1 88.68 High High
Myeloid Leukemia 2 86.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry was used to analyse 18- and 26-month-old transgenic mice overexpressing the human beta-amyloid precursor protein under the platelet-derived growth factor-beta promoter with regard to presence and distribution of neuropeptides.
Spec (analyse) Positive_regulation (overexpressing) of Gene_expression (overexpressing) of platelet-derived growth factor-beta promoter in platelet associated with targeted disruption, alzheimer's dementia and neuropeptide
1) Confidence 0.38 Published 2000 Journal Neuroscience Section Abstract Doc Link 11008166 Disease Relevance 0.58 Pain Relevance 0.20
IQ-tag-PDGFR transfected and mock transfected cells were injected locally for imaging and then probed via systemic injection of GH680 (2 nmoles).
Positive_regulation (transfected) of Gene_expression (transfected) of PDGFR associated with imagery
2) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1919420 Disease Relevance 0 Pain Relevance 0.42
A second mechanism of TK dysfunction in malignant cells is via the overexpression of a TK or its ligand; eg, the overexpression of VEGFR, PDGFR, or EGFR or their ligands in RCC (Gomella et al 1989; Mydlo et al 1989; Atlas et al 1992; Uhlman et al 1995; Iliopoulos et al 1996; Ramp et al 2000; Gunningham et al 2001; Na et al 2003; Sulzbacher et al 2003, Yildiz et al 2004; Minardi et al 2005; Xu et al 2005).
Positive_regulation (overexpression) of Gene_expression (overexpression) of PDGFR in Atlas associated with malignant neoplastic disease and renal cell carcinoma
3) Confidence 0.27 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.67 Pain Relevance 0.04
In gliomas, analysis of PDGF/PDGFR expression suggested the presence of autocrine and paracrine loops of PDGF in glioma activating PDGFR-?
Positive_regulation (/) of Gene_expression (expression) of PDGFR associated with glioma
4) Confidence 0.24 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.03 Pain Relevance 0.03
, PDGFR-B and IGFBP-3) found to be overexpressed in gastric cancers relative to PN and AN (with the exception of CFD/Adipsin which was overexpressed in PN relative to gastric cancers and AN) were studied for their protein levels in tumour, corresponding PN and in AN tissues.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of PDGFR-B associated with cancer and stomach cancer
5) Confidence 0.03 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 0.55 Pain Relevance 0

General Comments

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