INT91173

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Context Info
Confidence 0.65
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 33
Total Number 37
Disease Relevance 32.55
Pain Relevance 3.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pdgfrb) plasma membrane (Pdgfrb) nucleus (Pdgfrb)
kinase activity (Pdgfrb) lysosome (Pdgfrb) cytoplasm (Pdgfrb)
Anatomy Link Frequency
platelet 4
precursor cell 1
vasculature 1
lungs 1
mesenchymal cells 1
Pdgfrb (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 25 100.00 Very High Very High Very High
Central nervous system 18 100.00 Very High Very High Very High
fibrosis 179 98.92 Very High Very High Very High
Neuropeptide 7 98.20 Very High Very High Very High
imagery 70 97.84 Very High Very High Very High
Inflammation 66 95.40 Very High Very High Very High
cytokine 88 94.68 High High
Opioid 23 90.24 High High
chemokine 49 88.76 High High
metalloproteinase 39 88.24 High High
Disease Link Frequency Relevance Heat
Glioma 49 100.00 Very High Very High Very High
Alzheimer's Dementia 4 100.00 Very High Very High Very High
Cancer 1764 99.98 Very High Very High Very High
Targeted Disruption 36 99.88 Very High Very High Very High
Stomach Cancer 291 99.84 Very High Very High Very High
Chronic Myelomonocytic Leukemia 30 99.76 Very High Very High Very High
Systemic Mastocytosis 24 99.74 Very High Very High Very High
Hypereosinophilic Syndrome 28 99.56 Very High Very High Very High
Pulmonary Fibrosis 100 98.92 Very High Very High Very High
Syndrome 20 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stem cell or early precursor cell markers of CNS origin (nestin, Notch1, PDGFR-?)
Gene_expression (Stem cell) of PDGFR in precursor cell associated with central nervous system
1) Confidence 0.65 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826742 Disease Relevance 0.27 Pain Relevance 0.14
Together, these examples suggest potential benefits of targeting PDGFR-?
Gene_expression (targeting) of PDGFR
2) Confidence 0.63 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 0.69 Pain Relevance 0.03
In agreement with this, we found that tumors grew faster in mice with activated PDGFR-?
Gene_expression (grew) of PDGFR associated with cancer
3) Confidence 0.63 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 1.05 Pain Relevance 0
Generation of D849N-mutant mice carrying an activating mutation in the PDGFR-?
Gene_expression (Generation) of PDGFR
4) Confidence 0.56 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 1.02 Pain Relevance 0.03
are mainly expressed in the developing vasculature, where PDGF-BB is produced by endothelial cells and PDGFR-?
Gene_expression (produced) of PDGFR in vasculature
5) Confidence 0.55 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2234427 Disease Relevance 0.63 Pain Relevance 0
Immunohistochemistry was used to analyse 18- and 26-month-old transgenic mice overexpressing the human beta-amyloid precursor protein under the platelet-derived growth factor-beta promoter with regard to presence and distribution of neuropeptides.
Gene_expression (overexpressing) of platelet-derived growth factor-beta promoter in platelet associated with targeted disruption, alzheimer's dementia and neuropeptide
6) Confidence 0.52 Published 2000 Journal Neuroscience Section Abstract Doc Link 11008166 Disease Relevance 0.58 Pain Relevance 0.20
Significant benefits were obtained when empiric use of imatinib in CEL and CMML led to significant clinical benefit and the discovery of the role of rearrangements of the platelet derived growth factor receptor -alpha (PDGFRa-FIP1L1 in CEL and SMCD) and -beta (PDGFRb through TEL-PDGFRb) for CMML).
Gene_expression (through) of PDGFRb in platelet associated with chronic myelomonocytic leukemia, hypereosinophilic syndrome and systemic mastocytosis
7) Confidence 0.48 Published 2007 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC2721304 Disease Relevance 2.16 Pain Relevance 0
IQ-tag-PDGFR transfected and mock transfected cells were injected locally for imaging and then probed via systemic injection of GH680 (2 nmoles).
Gene_expression (transfected) of PDGFR associated with imagery
8) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1919420 Disease Relevance 0 Pain Relevance 0.42
Significant benefits were obtained when empiric use of imatinib in CEL and CMML led to significant clinical benefit and the discovery of the role of rearrangements of the platelet derived growth factor receptor -alpha (PDGFRa-FIP1L1 in CEL and SMCD) and -beta (PDGFRb through TEL-PDGFRb) for CMML).
Gene_expression (through) of TEL-PDGFRb in platelet associated with chronic myelomonocytic leukemia, hypereosinophilic syndrome and systemic mastocytosis
9) Confidence 0.42 Published 2007 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC2721304 Disease Relevance 2.16 Pain Relevance 0
A bicistronic construct expressing dsRed and a fusion protein with IQ-tag fused to the amino terminus of the platelet-derived growth factor receptor (PDGFR) transmembrane domain was subsequently created to directly image protein expression and tumor cells.
Gene_expression (expression) of PDGFR in platelet associated with cancer
10) Confidence 0.40 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1919420 Disease Relevance 0.18 Pain Relevance 0.04
Agents that downregulate PDGFR expression at the cell surface of mesenchymal cells could also be of potential therapeutic value.
Gene_expression (expression) of PDGFR in mesenchymal cells
11) Confidence 0.38 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.93 Pain Relevance 0.25
In gliomas, analysis of PDGF/PDGFR expression suggested the presence of autocrine and paracrine loops of PDGF in glioma activating PDGFR-?
Gene_expression (expression) of PDGFR associated with glioma
12) Confidence 0.38 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.03 Pain Relevance 0.03
Firstly, PDGF and PDGFR are expressed at low levels in normal adults, while elevated levels are detected in lungs of patients with radiation-induced pulmonary fibrosis [70].
Gene_expression (expressed) of PDGFR in lungs associated with fibrosis and pulmonary fibrosis
13) Confidence 0.38 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.24 Pain Relevance 0.52
A second mechanism of TK dysfunction in malignant cells is via the overexpression of a TK or its ligand; eg, the overexpression of VEGFR, PDGFR, or EGFR or their ligands in RCC (Gomella et al 1989; Mydlo et al 1989; Atlas et al 1992; Uhlman et al 1995; Iliopoulos et al 1996; Ramp et al 2000; Gunningham et al 2001; Na et al 2003; Sulzbacher et al 2003, Yildiz et al 2004; Minardi et al 2005; Xu et al 2005).
Gene_expression (overexpression) of PDGFR in Atlas associated with malignant neoplastic disease and renal cell carcinoma
14) Confidence 0.36 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.67 Pain Relevance 0.04
An inverse correlation between the expression of PDGFRb and PDGFd was observed on our MM cells.
Gene_expression (expression) of PDGFRb associated with mesothelioma
15) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2850899 Disease Relevance 1.59 Pain Relevance 0
in glioma cells, while PDGFR-?
Gene_expression (while) of PDGFR associated with glioma
16) Confidence 0.33 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.24 Pain Relevance 0.07
M), or the PDGFR antagonist, (tyrosphostin 9; 100 ?
Gene_expression (antagonist) of PDGFR associated with antagonist
17) Confidence 0.29 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.07 Pain Relevance 0.43
In gliomas, analysis of PDGF/PDGFR expression suggested the presence of autocrine and paracrine loops of PDGF in glioma activating PDGFR-?
Gene_expression (presence) of PDGFR associated with glioma
18) Confidence 0.29 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.14 Pain Relevance 0.07
Moreover, tumor shrinkage could be observed even in cases with less favorable KIT/PDGFR?
Gene_expression (/) of PDGFR associated with cancer
19) Confidence 0.27 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 0.95 Pain Relevance 0
In light of these results the presence of a less sensitive mutation like Exon 9 or of a wild-type KIT/PDGFR?
Gene_expression (/) of PDGFR
20) Confidence 0.27 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 0.75 Pain Relevance 0

General Comments

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