INT9118

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Context Info
Confidence 0.75
First Reported 1989
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 37
Total Number 40
Disease Relevance 17.19
Pain Relevance 6.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ceacam1) cell adhesion (Ceacam1) plasma membrane (Ceacam1)
Anatomy Link Frequency
osteoblast 2
NK cells 2
chondrocytes 1
macrophage 1
dendrites 1
Ceacam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 34 100.00 Very High Very High Very High
metalloproteinase 27 100.00 Very High Very High Very High
spondylitis 27 99.72 Very High Very High Very High
cINOD 1 99.64 Very High Very High Very High
chemokine 4 99.58 Very High Very High Very High
qutenza 1 99.40 Very High Very High Very High
corticosteroid 3 97.84 Very High Very High Very High
Pain 34 97.56 Very High Very High Very High
cytokine 23 94.20 High High
anesthesia 11 93.00 High High
Disease Link Frequency Relevance Heat
Adhesions 13 100.00 Very High Very High Very High
Respiratory Syncytial Virus 348 99.88 Very High Very High Very High
Low Back Pain 34 99.72 Very High Very High Very High
Osteoporosis 167 99.32 Very High Very High Very High
Calcification 14 98.92 Very High Very High Very High
Cirrhosis 4 97.92 Very High Very High Very High
Pseudomonas Infection 1 97.84 Very High Very High Very High
Phosphate Metabolism Disorders 10 97.80 Very High Very High Very High
Pain 26 97.56 Very High Very High Very High
Rickets 1 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The co-expression of osteocalcin (OC) with the capsaicin receptor (VR1) and vanilloid receptor 1-like receptor (VRL-1) was examined in the dorsal root (DRG) and trigeminal ganglia (TG).
Gene_expression (co-expression) of osteocalcin in dorsal root associated with qutenza
1) Confidence 0.75 Published 2002 Journal Brain Res. Section Abstract Doc Link 12470885 Disease Relevance 0.07 Pain Relevance 0.19
Samples of the culture medium were analyzed for the presence of osteocalcin using a radioimmunoassay kit (Biomedical Technologies Inc.
Spec (analyzed) Gene_expression (presence) of osteocalcin
2) Confidence 0.59 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782207 Disease Relevance 0 Pain Relevance 0.10
The study examined the expression of matrix metalloproteinases (MMPs), type I collagen and osteocalcin during bone healing in a rat calvarial experimental defect model.
Spec (examined) Gene_expression (expression) of osteocalcin associated with metalloproteinase
3) Confidence 0.56 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.25
The expression of type I collagen, osteocalcin and MMPs 2 and 13 increased toward week 2 and decreased thereafter, whereas the expression of MMP 8 was the highest on day 1.
Gene_expression (expression) of osteocalcin associated with metalloproteinase
4) Confidence 0.56 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.37
RNA was extracted from tissue that filled the original bone defect on days 1 and 3 and in weeks 1, 2, 3, 5, 8, 10, 12, 18, and 24 and processed for quantitative analysis of expression of type I collagen, osteocalcin and matrix metalloproteinases (MMPs) 2, 8, and 13 by using real-time polymerase chain reaction.
Gene_expression (expression) of osteocalcin associated with metalloproteinase
5) Confidence 0.56 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.34
Osteocalcin was present in concentration similar to that previously reported (5) and concentration was upregulated by addition of vitamin D to the culture medium (Table 1).


Gene_expression (present) of Osteocalcin
6) Confidence 0.53 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782207 Disease Relevance 0.16 Pain Relevance 0.09
Remarkably, we observed that the NK-inhibitory receptor CEACAM1 (carcino-embryonic antigen-cell adhesion molecule) is highly expressed among AS-derived NK cells.
Gene_expression (expressed) of CEACAM1 in NK cells associated with spondylitis and adhesions
7) Confidence 0.45 Published 2005 Journal Int. Immunol. Section Abstract Doc Link 15937057 Disease Relevance 1.08 Pain Relevance 0.53
These results may indicate that NK cells and CEACAM1 play a role in AS pathogenesis and implicate chemokines in the mechanism of CEACAM1 expression.
Gene_expression (expression) of CEACAM1 in NK cells associated with chemokine and spondylitis
8) Confidence 0.45 Published 2005 Journal Int. Immunol. Section Abstract Doc Link 15937057 Disease Relevance 0.93 Pain Relevance 0.49
Finally, we demonstrated that CEACAM1 expression is induced by IL-8 and SDF-1 (stromal cell derived factor), both of which are present in high levels in the sera of AS patients.
Gene_expression (expression) of CEACAM1 in stromal cell associated with spondylitis
9) Confidence 0.45 Published 2005 Journal Int. Immunol. Section Abstract Doc Link 15937057 Disease Relevance 1.03 Pain Relevance 0.51
We performed a study on the phosphorus/calcium metabolism and serum levels of osteocalcin (BGP), a protein proposed as constituting the bone turnover index in 31 patients receiving TPN (age 57 +/- 14 years, 22 males and 9 females) diagnosed as suffering from pathology of the digestive tract or geno-urinary pathology.
Gene_expression (levels) of osteocalcin in digestive tract
10) Confidence 0.44 Published 1992 Journal Nutr Hosp Section Abstract Doc Link 1391109 Disease Relevance 0.25 Pain Relevance 0.10
The currently known ecto-nucleotidases include members of the eNTPDase family, eNPP family, alkaline phosphatases, and ecto-5?
Gene_expression (include) of ecto-nucleotidases
11) Confidence 0.40 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096649 Disease Relevance 0.14 Pain Relevance 0.21
Serum levels of osteocalcin - a marker of bone formation - and urinary fluoride levels were significantly higher in drinkers of St-Yorre water than in controls.
Gene_expression (levels) of osteocalcin
12) Confidence 0.36 Published 1989 Journal Presse Med Section Abstract Doc Link 2529522 Disease Relevance 0.18 Pain Relevance 0.09
The ectoATPase enzyme was present on the membranes of the dendrites and nerve terminals and in the synapses of the habenula.
Gene_expression (present) of ectoATPase in dendrites
13) Confidence 0.35 Published 1995 Journal Neuroscience Section Abstract Doc Link 7651618 Disease Relevance 0.06 Pain Relevance 0.17
Serum levels of osteocalcin, alkaline phosphatase and ostase, as markers for bone formation, were tested.
Gene_expression (levels) of osteocalcin
14) Confidence 0.32 Published 2000 Journal Z Rheumatol Section Abstract Doc Link 11155797 Disease Relevance 0.65 Pain Relevance 0.31
When the vertebral growth zones blended with the arch centra, chondrocytes expressing osteocalcin was observed (Figure 6O).


Gene_expression (expressing) of osteocalcin in chondrocytes
15) Confidence 0.24 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0.15 Pain Relevance 0
Some of the key transcription factors in bone metabolism include runx2 and osterix [18], involved in the differentiation of mesenchymal stem cells (MSC) into osteoblasts that express bone matrix (col1a) and matrix mineralizing (osteocalcin and osteonectin) genes.
Gene_expression (express) of osteocalcin in stem cells
16) Confidence 0.18 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0.24 Pain Relevance 0.03
ADSCs mineralize their extracellular matrix (ECM) and show increased expression of osteocalcin and alkaline phosphatase (ALP).[12] These factors may make ADSCs a viable clinical alternative to BMSCs.
Gene_expression (expression) of osteocalcin in extracellular matrix
17) Confidence 0.18 Published 2008 Journal Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India Section Body Doc Link PMC2739564 Disease Relevance 0.19 Pain Relevance 0.16
Serum levels of osteocalcin (BGP) and parathyroid hormone (PTH) in patients of hepatic cirrhosis without osteodystrophy were lower than those with osteodystrophy.
Gene_expression (levels) of osteocalcin in parathyroid associated with phosphate metabolism disorders and cirrhosis
18) Confidence 0.18 Published 1998 Journal Nippon Rinsho Section Abstract Doc Link 9648489 Disease Relevance 1.77 Pain Relevance 0.07
Serum osteocalcin and cross-laps levels were significantly reduced.
Gene_expression (reduced) of osteocalcin
19) Confidence 0.17 Published 2010 Journal International Journal of Ayurveda Research Section Body Doc Link PMC2924974 Disease Relevance 0.53 Pain Relevance 0.03
The selective ecto-ATPase inhibitor, ARL-67156 (100, 200 microM) and suramin (100, 200 microM), an ecto-nucleotidase inhibitor as well as a P2 receptor antagonist, produced an increase in baseline and distension-induced discharge.
Gene_expression (produced) of ecto-ATPase associated with antagonist
20) Confidence 0.16 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15555643 Disease Relevance 0 Pain Relevance 0.40

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