INT9119

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Context Info
Confidence 0.42
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 5.21
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TAF9) nucleolus (TAF9) nucleus (TAF9)
DNA binding (TAF9) kinase activity (TAF9)
TAF9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 8 99.90 Very High Very High Very High
Codeine 17 99.62 Very High Very High Very High
corticosteroid 72 99.44 Very High Very High Very High
antagonist 5 96.48 Very High Very High Very High
Inflammation 19 94.00 High High
Inflammatory response 9 57.24 Quite High
Pain 5 55.12 Quite High
metalloproteinase 9 28.12 Quite Low
Action potential 33 5.00 Very Low Very Low Very Low
cytokine 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathy 240 100.00 Very High Very High Very High
Muscle Disease 273 99.96 Very High Very High Very High
Cancer 87 98.84 Very High Very High Very High
Hyperglycemia 19 98.20 Very High Very High Very High
Reprotox - General 1 5 98.20 Very High Very High Very High
Multiple Organ Failure 27 96.60 Very High Very High Very High
INFLAMMATION 25 94.00 High High
Asthma 6 93.24 High High
Hypoglycemia 6 93.24 High High
Aneuploidy 8 92.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Addition of exogenous BMP-6 to DU-145 prostate cancer cell cultures inhibited their growth by up-regulation of several cyclin-dependent kinase inhibitors such as p21/CIP, p18, and p19.
Negative_regulation (inhibitors) of CIP associated with reprotox - general 1
1) Confidence 0.42 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15548695 Disease Relevance 0.59 Pain Relevance 0.14
The p21WAF1/CIP1 is a cyclin kinase inhibitor that can induce cell growth arrest by inactivating cyclin-dependent kinase (Cdk) or by inhibiting the activity of proliferating cell nuclear antigen (PCNA).
Negative_regulation (inhibitor) of CIP1
2) Confidence 0.42 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.34 Pain Relevance 0
CSs indeed showed a preventive effect on CIP/CIM in one prospective trial [44], and in a second prospective trial a trend toward beneficial effect was noticed [43].
Negative_regulation (effect) of CIP associated with neuropathy, corticosteroid and muscle disease
3) Confidence 0.36 Published 2008 Journal Crit Care Section Body Doc Link PMC2646339 Disease Relevance 1.22 Pain Relevance 0.32
A systematic review of the available literature on the optimal approach for preventing CIP/CIM seems warranted.



Negative_regulation (preventing) of CIP associated with neuropathy and muscle disease
4) Confidence 0.31 Published 2008 Journal Crit Care Section Abstract Doc Link PMC2646339 Disease Relevance 1.10 Pain Relevance 0.08
Avoiding hyperglycemia using insulin therapy to maintain strict glycemic control therefore may be beneficial to prevent CIP/CIM.
Negative_regulation (prevent) of CIP associated with neuropathy, hyperglycemia and muscle disease
5) Confidence 0.31 Published 2008 Journal Crit Care Section Body Doc Link PMC2646339 Disease Relevance 0.97 Pain Relevance 0.05
Two out of eight volunteers were unable to O-dealkylate codeine into morphine and lack therefore the cytochrome P450 IID6 isoenzyme.
Negative_regulation (lack) of P450 IID6 isoenzyme associated with morphine and codeine
6) Confidence 0.09 Published 1992 Journal Biopharm Drug Dispos Section Abstract Doc Link 1391681 Disease Relevance 0 Pain Relevance 1.57

General Comments

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