INT912

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Context Info
Confidence 0.79
First Reported 1973
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 91
Total Number 92
Disease Relevance 23.61
Pain Relevance 15.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FSHR) plasma membrane (FSHR) signal transducer activity (FSHR)
Anatomy Link Frequency
follicle 21
pituitary 10
gland 4
gonadal 3
plasma 2
FSHR (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 22 100.00 Very High Very High Very High
Neuropeptide 114 99.98 Very High Very High Very High
Morphine 40 99.92 Very High Very High Very High
Endogenous opioid 25 99.76 Very High Very High Very High
narcan 75 99.72 Very High Very High Very High
agonist 231 99.46 Very High Very High Very High
opiate 26 99.38 Very High Very High Very High
antagonist 206 99.14 Very High Very High Very High
Dopamine 37 99.14 Very High Very High Very High
Opioid 38 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pituitary Cancer 26 100.00 Very High Very High Very High
Reprotox - General 1 142 99.84 Very High Very High Very High
Anovulation 54 98.48 Very High Very High Very High
Cv General 3 Under Development 1 98.36 Very High Very High Very High
Reprotox - General 3 216 98.20 Very High Very High Very High
Acth-secreting Pituitary Adenoma 6 97.16 Very High Very High Very High
Endometriosis (extended) 163 96.80 Very High Very High Very High
Ovarian Cysts 22 96.64 Very High Very High Very High
Stress 93 96.20 Very High Very High Very High
Adenoma 11 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ten men who had FSH-secreting pituitary adenomas were evaluated before and 4-6 weeks after transsphenoidal surgery to determine whether reduction of adenoma mass would ameliorate the hormonal abnormalities associated with these adenomas.
Localization (secreting) of FSH in pituitary associated with adenoma, congenital anomalies and pituitary cancer
1) Confidence 0.79 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6404924 Disease Relevance 0.67 Pain Relevance 0
The elimination half-life of FSH obtained from cases received abdominal SC injections was very similar to those of previous studies employing fully suppressed pituitary endogenous FSH secretion.
Localization (secretion) of FSH in pituitary
2) Confidence 0.79 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0
Thus, the lower level fluctuation of baseline endogenous FSH secretion may not affect the result of pharmacokinetic analysis in the present study.
Localization (secretion) of FSH
3) Confidence 0.79 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0
We recognize that there may present minimal endogenous FSH secretion in this study.
Localization (secretion) of FSH
4) Confidence 0.79 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0
Oral contraceptive mechanisms include 1) blockage of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release, 2) alteration of motility in the fallopian tubes 3) modification of endometrial maturation, and 4) rendering the cervical mucus hostile to sperm migration.
Localization (release) of follicle-stimulating hormone in sperm
5) Confidence 0.78 Published 1973 Journal Am J Pharm Section Abstract Doc Link 12306537 Disease Relevance 0.78 Pain Relevance 0.14
Oral contraceptive mechanisms include 1) blockage of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release, 2) alteration of motility in the fallopian tubes 3) modification of endometrial maturation, and 4) rendering the cervical mucus hostile to sperm migration.
Localization (release) of FSH in sperm
6) Confidence 0.78 Published 1973 Journal Am J Pharm Section Abstract Doc Link 12306537 Disease Relevance 0.78 Pain Relevance 0.14
Advances in molecular biology techniques made it possible to produce recombinant FSH, which is secreted from genetically engineered Chinese hamster ovary cells [4].
Localization (secreted) of FSH in ovary
7) Confidence 0.77 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC270000 Disease Relevance 0.16 Pain Relevance 0.06
METHODS: We present a case report of a 29-year-old woman, including detailed laboratory, radiologic, and pathologic findings, who was diagnosed as having an FSH-secreting pituitary tumor.
Localization (secreting) of FSH in pituitary
8) Confidence 0.73 Published 2006 Journal Endocr Pract Section Body Doc Link 16901798 Disease Relevance 0.37 Pain Relevance 0
OBJECTIVE: To report a case of a follicle-stimulating hormone (FSH)-secreting pituitary adenoma, which manifested with oligomenorrhea, dysmenorrhea, and multiple bilateral ovarian cysts.
Localization (secreting) of follicle-stimulating hormone in pituitary associated with pituitary cancer, dismenorea, ovarian cysts and reprotox - general 1
9) Confidence 0.73 Published 2006 Journal Endocr Pract Section Abstract Doc Link 16901798 Disease Relevance 0.54 Pain Relevance 0.10
OBJECTIVE: To report a case of a follicle-stimulating hormone (FSH)-secreting pituitary adenoma, which manifested with oligomenorrhea, dysmenorrhea, and multiple bilateral ovarian cysts.
Localization (secreting) of FSH in pituitary associated with pituitary cancer, dismenorea, ovarian cysts and reprotox - general 1
10) Confidence 0.73 Published 2006 Journal Endocr Pract Section Abstract Doc Link 16901798 Disease Relevance 0.54 Pain Relevance 0.10
Our analysis also shows that there are three LGR subfamilies: (i) the glycoprotein hormone receptors LSHR_Hum, FSHR_Hum, TSHR_Hum, Q8SX01_Dro and Q9NDI1_Dro (ii) LGR4_Hum LGR5_Hum and LGR6_Hum (iii) LGR5_Hum, LGR7_Hum and LGR8_Hum, Q9VBP0_Dro, and Q9VYG0_Dro.
Localization (iii) of LGR
11) Confidence 0.73 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1192796 Disease Relevance 0 Pain Relevance 0.12
Our analysis also shows that there are three LGR subfamilies: (i) the glycoprotein hormone receptors LSHR_Hum, FSHR_Hum, TSHR_Hum, Q8SX01_Dro and Q9NDI1_Dro (ii) LGR4_Hum LGR5_Hum and LGR6_Hum (iii) LGR5_Hum, LGR7_Hum and LGR8_Hum, Q9VBP0_Dro, and Q9VYG0_Dro.
Localization (receptors) of LGR
12) Confidence 0.73 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1192796 Disease Relevance 0 Pain Relevance 0.09
Our analysis also shows that there are three LGR subfamilies: (i) the glycoprotein hormone receptors LSHR_Hum, FSHR_Hum, TSHR_Hum, Q8SX01_Dro and Q9NDI1_Dro (ii) LGR4_Hum LGR5_Hum and LGR6_Hum (iii) LGR5_Hum, LGR7_Hum and LGR8_Hum, Q9VBP0_Dro, and Q9VYG0_Dro.
Localization (receptors) of LGR
13) Confidence 0.73 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1192796 Disease Relevance 0 Pain Relevance 0.17
Our analysis also shows that there are three LGR subfamilies: (i) the glycoprotein hormone receptors LSHR_Hum, FSHR_Hum, TSHR_Hum, Q8SX01_Dro and Q9NDI1_Dro (ii) LGR4_Hum LGR5_Hum and LGR6_Hum (iii) LGR5_Hum, LGR7_Hum and LGR8_Hum, Q9VBP0_Dro, and Q9VYG0_Dro.
Localization (iii) of LGR
14) Confidence 0.73 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1192796 Disease Relevance 0 Pain Relevance 0.12
Our analysis also shows that there are three LGR subfamilies: (i) the glycoprotein hormone receptors LSHR_Hum, FSHR_Hum, TSHR_Hum, Q8SX01_Dro and Q9NDI1_Dro (ii) LGR4_Hum LGR5_Hum and LGR6_Hum (iii) LGR5_Hum, LGR7_Hum and LGR8_Hum, Q9VBP0_Dro, and Q9VYG0_Dro.
Localization (iii) of LGR
15) Confidence 0.73 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1192796 Disease Relevance 0 Pain Relevance 0.17
In tissue culture, the second, third, and fourth specimens released ACTH, alpha-subunit, FSH, and LH and responded to corticotropin-releasing hormone with increased release of ACTH, alpha-subunit, FSH, and LH.
Localization (release) of FSH
16) Confidence 0.69 Published 1991 Journal Hum. Pathol. Section Abstract Doc Link 1649119 Disease Relevance 0.88 Pain Relevance 0.07
In tissue culture, the second, third, and fourth specimens released ACTH, alpha-subunit, FSH, and LH and responded to corticotropin-releasing hormone with increased release of ACTH, alpha-subunit, FSH, and LH.
Localization (released) of FSH
17) Confidence 0.69 Published 1991 Journal Hum. Pathol. Section Abstract Doc Link 1649119 Disease Relevance 0.91 Pain Relevance 0.07
The costs per cycle of r FSH and HP FSH were compared in 2 trials and in both the cost per cycle were higher for rFSH even though in both trials a lower FSH dose could be used.31
Localization (cycle) of FSH
18) Confidence 0.68 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971716 Disease Relevance 0.08 Pain Relevance 0
There are three classes of anovulation, ie, WHO I, WHO II and WHO III.15–17 Women with WHO class I anovulation, which accounts for 10% of anovulatory women, have low or low–normal serum FSH concentrations and low serum estradiol concentrations due to decreased hypothalamic secretion of gonadotropin-releasing hormone (GnRH) or pituitary unresponsiveness to GnRH.
Localization (secretion) of FSH in pituitary associated with anovulation
19) Confidence 0.68 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971716 Disease Relevance 0.86 Pain Relevance 0
The costs per cycle of r FSH and HP FSH were compared in 2 trials and in both the cost per cycle were higher for rFSH even though in both trials a lower FSH dose could be used.31
Localization (cycle) of FSH
20) Confidence 0.68 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971716 Disease Relevance 0.08 Pain Relevance 0

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