INT91209

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Context Info
Confidence 0.36
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 12.02
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (VIM) plasma membrane (VIM) cytoskeleton (VIM)
cytoplasm (VIM)
Anatomy Link Frequency
spleen 2
histiocytes 1
monocytes 1
glial cell 1
smooth muscle 1
VIM (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 7 90.56 High High
fifth nerve 3 83.36 Quite High
Trigeminal neuralgia 1 82.40 Quite High
abdominal pain 11 81.52 Quite High
fibrosis 16 76.08 Quite High
Spinal cord 1 68.16 Quite High
imagery 11 52.64 Quite High
Bile 18 52.32 Quite High
Chronic pancreatitis 18 46.32 Quite Low
Inflammation 7 37.28 Quite Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 5 100.00 Very High Very High Very High
Melanoma 41 99.70 Very High Very High Very High
Carcinosarcoma 2 99.00 Very High Very High Very High
Carcinoma 38 98.14 Very High Very High Very High
Necrosis 17 97.88 Very High Very High Very High
Apoptosis 6 97.36 Very High Very High Very High
Adhesions 13 97.20 Very High Very High Very High
Severe Combined Immunodeficiency 15 96.52 Very High Very High Very High
Metastasis 55 95.66 Very High Very High Very High
Multiple Endocrine Neoplasia Type 1 104 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoreactivity for vimentin was recognized in cytoplasm adjacent to inclusions.
vimentin Binding (recognized) of
1) Confidence 0.36 Published 2000 Journal Ultrastruct Pathol Section Abstract Doc Link 11013967 Disease Relevance 0.66 Pain Relevance 0.12
Alcover et al. (27) have demonstrated that anti-vimentin antibodies in patients with autoimmune diseases interact preferentially with a specific domain of the protein, a peptide with a molecular weight of 30 kDa that is close to the amino-terminal of intact vimentin.
vimentin Binding (interact) of associated with autoimmune disease
2) Confidence 0.34 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2528299 Disease Relevance 0.85 Pain Relevance 0
SPTPs showed strong cellular immunoreactivity for vimentin and focal weak keratin reactivity.
vimentin Binding (immunoreactivity) of
3) Confidence 0.24 Published 2004 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 15151205 Disease Relevance 0.58 Pain Relevance 0.08
These cells were strongly immunoreactive with CD34, Bcl-2, CD99, and vimentin, but were negative with S100 protein, smooth muscle actin, and epithelial membrane antigen.
vimentin Binding (immunoreactive) of in smooth muscle
4) Confidence 0.24 Published 2004 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 14987150 Disease Relevance 0.84 Pain Relevance 0.12
Thus, a broader panel of immuno-markers may be useful in distinguishing between metastases of malignant melanoma and other metastatic malignancies when the lesion is morphologically undifferentiated; Gupta et al. [15], in fact, reported four cases of morphologically undifferentiated melanoma that showed a positivity for HMB45 (two cases), S100 (one case), vimentin (three cases), NKI/C3 (two cases), NKI/Bteb (one case) and CK (three cases).
vimentin Binding (positivity) of associated with melanoma, carcinoma and metastasis
5) Confidence 0.22 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2396655 Disease Relevance 1.37 Pain Relevance 0
Immunohistochemistry revealed a strong immunoreactivity for cytokeratin, vimentin and CK5.
vimentin Binding (immunoreactivity) of
6) Confidence 0.22 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC3016302 Disease Relevance 1.19 Pain Relevance 0.08
Sarcomatoid carcinomas can be differentiated from carcinosarcomas which immunohistochemically show cytokeratin and vimentin reactivity and are, therefore, not considered to be true carcinomas [16].
vimentin Binding (reactivity) of associated with carcinosarcoma and carcinoma
7) Confidence 0.21 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC3016302 Disease Relevance 1.27 Pain Relevance 0.08
The incipient vascularization of the placenta by vessels emanating from these folds of connective tissue could be confirmed by immunostaining for vimentin and actin (Figure 5C–D).
vimentin Binding (immunostaining) of in connective tissue
8) Confidence 0.14 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2702307 Disease Relevance 0.42 Pain Relevance 0
By immunofluorescence staining on spleen sections, using an antibody recognizing exclusively human vimentin and not mouse vimentin as verified by western blotting on mouse 3T3 cells (data not shown), we demonstrated that aMSC and pMSC survived in the spleen up to 8 weeks after transplantation (Fig. 5A).
vimentin Binding (recognizing) of in spleen
9) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.29 Pain Relevance 0
Inimitable immunofluorescent microscopy represented in our high magnification images of vinculin, vimentin, and the actin cytoskeleton highlights the differences in fibroblast adhesion between fabricated silicone surfaces.
vimentin Binding (images) of in fibroblast associated with adhesions
10) Confidence 0.10 Published 2010 Journal Eplasty Section Abstract Doc Link PMC2860220 Disease Relevance 0.18 Pain Relevance 0
By immunofluorescence staining on spleen sections, using an antibody recognizing exclusively human vimentin and not mouse vimentin as verified by western blotting on mouse 3T3 cells (data not shown), we demonstrated that aMSC and pMSC survived in the spleen up to 8 weeks after transplantation (Fig. 5A).
vimentin Binding (recognizing) of in spleen
11) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.29 Pain Relevance 0
Histochemistry using Masson's trichrome on serial sections showed that collagen deposition merges with vimentin- and ?
vimentin Binding (merges) of
12) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.39 Pain Relevance 0.04
The neoplastic cells demonstrated immunohistochemical staining characteristics similar to those of normal monocytes/histiocytes, namely strong immunoreactivity with CD163, CD68, lysozyme, NSE, and vimentin.
vimentin Binding (immunoreactivity) of in histiocytes
13) Confidence 0.08 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 1.60 Pain Relevance 0
As expected, abundant proteins were associated with many different peptides: vimentin, 23 peptides; HSP90?
vimentin Binding (associated) of
14) Confidence 0.05 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0 Pain Relevance 0
Although menin has been identified primarily as a nuclear protein, recent studies have reported its interaction with the glial fibrillary acid protein (GFAP) and with vimentin (components of intermediate filaments (IFs)), suggesting a putative role in glial cell oncogenesis.
vimentin Binding (interaction) of in glial cell
15) Confidence 0.04 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1594566 Disease Relevance 0.51 Pain Relevance 0
The neoplastic cells demonstrated immunohistochemical staining characteristics similar to those of normal monocytes/histiocytes, namely strong immunoreactivity with CD163, CD68, lysozyme, NSE, and vimentin.
vimentin Binding (immunoreactivity) of in monocytes
16) Confidence 0.03 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 1.60 Pain Relevance 0

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