INT91217

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Context Info
Confidence 0.48
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 16.57
Pain Relevance 6.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (BAG3) cytosol (BAG3) plasma membrane (BAG3)
cytoplasm (BAG3)
Anatomy Link Frequency
claw 1
head 1
body 1
BAG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 1123 99.64 Very High Very High Very High
withdrawal 1 95.48 Very High Very High Very High
Electroencephalography 61 94.24 High High
Versed 10 86.52 High High
Analgesic 17 85.60 High High
tolerance 7 84.88 Quite High
isoflurane 5 84.68 Quite High
Catecholamine 24 84.16 Quite High
anesthesia 56 79.56 Quite High
analgesia 30 56.16 Quite High
Disease Link Frequency Relevance Heat
Sleep Disorders 349 99.82 Very High Very High Very High
Cv General 3 Under Development 1079 99.64 Very High Very High Very High
Death 60 99.28 Very High Very High Very High
Critical Illness 63 99.08 Very High Very High Very High
Injury 104 98.64 Very High Very High Very High
Shock 54 97.12 Very High Very High Very High
Delirium 7 95.96 Very High Very High Very High
Dementia 1 95.44 Very High Very High Very High
Brain Injury 209 95.04 Very High Very High Very High
Apoptosis 22 94.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Knockdown of BAG3 enhanced HNE-induced cell death to the same extent as silencing HSF1, confirming the importance of BAG3 in the heat-shock-mediated defense against reactive electrophiles.
Positive_regulation (enhanced) of BAG3 associated with shock and death
1) Confidence 0.48 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.68 Pain Relevance 0.03
Various manipulations to the head and body during CPR can lead to high EMG values, which can cause an artificial increase of the BIS and may diminish the assessment of BIS values.
Positive_regulation (increase) of BIS in body
2) Confidence 0.47 Published 2008 Journal Int J Emerg Med Section Body Doc Link PMC2657270 Disease Relevance 0.27 Pain Relevance 0.03
However, increasing BIS values after stabilization of the circulation correlated with favourable outcome in this particular case, while decreasing values ended with death.
Positive_regulation (increasing) of BIS associated with death
3) Confidence 0.47 Published 2008 Journal Int J Emerg Med Section Body Doc Link PMC2657270 Disease Relevance 0.32 Pain Relevance 0.04
The last increase of BIS possibly represents improved cerebral activity following a rise of mean arterial pressure caused by a final bolus of 5 mg epinephrine prior to stopping CPR

Discussion

Positive_regulation (increase) of BIS
4) Confidence 0.47 Published 2008 Journal Int J Emerg Med Section Body Doc Link PMC2657270 Disease Relevance 0.28 Pain Relevance 0.19
Surviving patients have decreased ICP, increased CPP, decreased CAP Index, increased StcO2, and increased BIS.
Positive_regulation (increased) of BIS associated with cva
5) Confidence 0.45 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.20 Pain Relevance 0.57
Good neurological outcome patients also have decreased ICP, increased CPP, decreased CAP Index, increased StcO2, and increased BIS.
Positive_regulation (increased) of BIS associated with cva
6) Confidence 0.45 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.33 Pain Relevance 0.60
Increased BIS is associated with increased StcO2.
Positive_regulation (Increased) of BIS
7) Confidence 0.45 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.63 Pain Relevance 0.55
Surviving and good neurological outcome patients have increased CPP, StcO2, and BIS and decreased ICP and CAP Index (Table 2).
Positive_regulation (increased) of BIS associated with cva
8) Confidence 0.45 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 0.79 Pain Relevance 0.35
We also observed that silencing BAG3 was associated with a dramatic loss in proteins belonging to the antiapoptotic Bcl-2 family, including Bcl-2, Bcl-xL, and Mcl-1.
Positive_regulation (silencing) of BAG3
9) Confidence 0.42 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.66 Pain Relevance 0
Direct laryngoscopy and intubation increased the BIS (56 +/- 7 to 83 +/- 11; p < 0.05, n = 10), as did a noxious pinch to the dew-claw (57 +/- 9; to 76 +/- 9; p < 0.05, n = 10).
Positive_regulation (increased) of BIS in claw
10) Confidence 0.40 Published 2000 Journal Vet. Res. Commun. Section Abstract Doc Link 11014605 Disease Relevance 0 Pain Relevance 0.21
The initial BIS value was 72 and decreased to 13 during CPR with an average value of 46?
Positive_regulation (initial) of BIS
11) Confidence 0.34 Published 2008 Journal Int J Emerg Med Section Body Doc Link PMC2657270 Disease Relevance 0.50 Pain Relevance 0.33
Variation in StcO2 and BIS are associated with changes in ICP and CPP.
Positive_regulation (Variation) of BIS associated with cva
12) Confidence 0.32 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.33 Pain Relevance 0.60
Other patients who may benefit from BIS and StcO2 monitoring without ICP monitoring are blunt trauma patients with intracranial hemorrhage, GCS score 9 to 12, and the need for mechanical ventilation and sedation.
Positive_regulation (monitoring) of BIS associated with injury, cva and sleep disorders
13) Confidence 0.32 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.88 Pain Relevance 0.54
Although we used BIS XP technology, a degree of susceptibility to increased BIS values as a consequence of electromyogram artefact remains [34].
Positive_regulation (increased) of BIS
14) Confidence 0.31 Published 2008 Journal Crit Care Section Body Doc Link PMC2447606 Disease Relevance 0.56 Pain Relevance 0
Surviving patients have decreased ICP, increased CPP, decreased CAP Index, increased StcO2, and increased BIS.
Positive_regulation (increased) of BIS associated with cva
15) Confidence 0.30 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.19 Pain Relevance 0.57
Good neurological outcome patients also have decreased ICP, increased CPP, decreased CAP Index, increased StcO2, and increased BIS.
Positive_regulation (increased) of BIS associated with cva
16) Confidence 0.30 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.32 Pain Relevance 0.60
But Puri22 reported two cases with paradoxical changes in BIS during N2O administration.
Positive_regulation (changes) of BIS
17) Confidence 0.25 Published 2007 Journal European journal of dentistry Section Body Doc Link PMC2609910 Disease Relevance 0.31 Pain Relevance 0.14
The effect of the electromyogram (EMG) signal may artificially increase the BIS number.
Spec (may) Positive_regulation (increase) of BIS
18) Confidence 0.25 Published 2008 Journal Crit Care Section Body Doc Link PMC2391268 Disease Relevance 0.27 Pain Relevance 0.16
They state that 'objective measures of sedation such as BIS have not yet been evaluated and are not yet proven in the ICU', based upon grade C evidence.
Neg (not) Positive_regulation (proven) of BIS associated with sleep disorders
19) Confidence 0.18 Published 2008 Journal Crit Care Section Body Doc Link PMC2391268 Disease Relevance 0.49 Pain Relevance 0.13
This is because many factors may alter the signal in the critically ill patient, particularly EMG signals, which can cause erroneously high BIS and PSI scores.
Positive_regulation (cause) of BIS associated with critical illness
20) Confidence 0.18 Published 2008 Journal Crit Care Section Body Doc Link PMC2391268 Disease Relevance 0.46 Pain Relevance 0.27

General Comments

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