INT91225

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Context Info
Confidence 0.57
First Reported 1998
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 14.77
Pain Relevance 5.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pla2g2a) extracellular space (Pla2g2a) endoplasmic reticulum (Pla2g2a)
Anatomy Link Frequency
Notocord 2
stems 2
sensory neurons 1
endothelial cells 1
plaques 1
Pla2g2a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 12 99.76 Very High Very High Very High
cytokine 11 99.62 Very High Very High Very High
Chronic pancreatitis 14 99.40 Very High Very High Very High
Inflammation 119 99.20 Very High Very High Very High
TRP channel 8 98.68 Very High Very High Very High
fibrosis 8 95.32 Very High Very High Very High
substance P 16 94.32 High High
calcitonin gene related peptide 17 94.16 High High
bradykinin 11 93.72 High High
Neuropeptide 3 93.16 High High
Disease Link Frequency Relevance Heat
Metaplasia 6 99.92 Very High Very High Very High
Pressure And Volume Under Development 30 99.88 Very High Very High Very High
Hypoxia 183 99.84 Very High Very High Very High
Pancreatitis 16 99.40 Very High Very High Very High
INFLAMMATION 141 99.36 Very High Very High Very High
Apoptosis 87 99.04 Very High Very High Very High
Death 8 98.72 Very High Very High Very High
Disease 152 98.68 Very High Very High Very High
Hypersensitivity 145 98.20 Very High Very High Very High
Fibrosis 12 95.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because the metabolic products of lipoxygenases (LOs) activate transient receptor potential vanilloid receptor-1 (TRPV1) in sensory neurons, we hypothesized that histamine excites sensory neurons by activating TRPV1 via phospholipase A2 (PLA2) and LO stimulation.
Positive_regulation (activating) of PLA2 in sensory neurons
1) Confidence 0.57 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17329430 Disease Relevance 0.24 Pain Relevance 0.09
It is well known that LPA is mainly produced via two major pathways, namely LPC conversion mediated by activation of ATX and phosphatidic acid conversion mediated by activation of phospholipase A2 (PLA2) [6,7].
Positive_regulation (activation) of PLA2
2) Confidence 0.41 Published 2008 Journal Mol Pain Section Body Doc Link PMC2277392 Disease Relevance 1.16 Pain Relevance 0.75
An alternative explanation could therefore be that the increase in sPLA2 mRNA observed in this study results to in overall increase in all arachidonic acid pathways.
Positive_regulation (increase) of sPLA2 mRNA
3) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.44 Pain Relevance 0.08
The increase in PLA2 was not as evident as that of iNOS (possibly due to differences in the quality of the antibody, as a greater standard error was seen for PLA2 stained cells).
Positive_regulation (increase) of PLA2
4) Confidence 0.35 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 0.50 Pain Relevance 0.03
Therefore, it is possible that the increase in iNOS described above reflects increased PLA2 activation by the AT2R.
Positive_regulation (increased) of PLA2
5) Confidence 0.25 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 0.66 Pain Relevance 0
This increase in PLA2 was consistent between 2% and 0.1% FBS backgrounds, but reached significance only in the 0.1% FBS background (P = 0.0374)

CGP42112A treatment decreased tumour burden in vivo

Positive_regulation (increase) of PLA2 associated with cancer
6) Confidence 0.25 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 0.97 Pain Relevance 0
Increased PLA2-II and PLA2-IV mRNA levels were associated with a higher degree of tissue destruction, ductal metaplasia and degree of fibrosis.
Positive_regulation (Increased) of PLA2-II associated with fibrosis and metaplasia
7) Confidence 0.25 Published 1998 Journal Langenbecks Arch Chir Suppl Kongressbd Section Abstract Doc Link 14518291 Disease Relevance 0.95 Pain Relevance 0.69
In contrast, PLA2-II and PLA2-IV mRNA were increased in 73% of the chronic pancreatitis samples (PLA2-II; 5.7-fold overexpressed; PLA2-IV:5.1-fold overexpressed; p < 0.05).
Positive_regulation (increased) of PLA2-II associated with chronic pancreatitis
8) Confidence 0.25 Published 1998 Journal Langenbecks Arch Chir Suppl Kongressbd Section Abstract Doc Link 14518291 Disease Relevance 0.89 Pain Relevance 0.61
Increases in intracellular Ca2+ initiate several second messenger pathways including the activation of phospholipase A2 (PLA2), phospholipase C (PLC) and Ca2+-dependent kinases, which can lead to the generation of AA and its metabolites, release of Ca2+ from intracellular stores and phosphorylation of nociceptive ion channels, respectively.
Positive_regulation (activation) of PLA2 associated with nociception
9) Confidence 0.24 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.54 Pain Relevance 0.53
Immunofluorescent staining for key signalling and secondary messengers, PLA2 and iNOS, were also increased by CGP42112A treatment in vitro.
Positive_regulation (increased) of PLA2
10) Confidence 0.24 Published 2010 Journal Cancer Cell Int Section Abstract Doc Link PMC2902462 Disease Relevance 1.40 Pain Relevance 0.04
In other words, increase of [Ca2+]i activates phospholipase A2 (PLA2), simulating generation of arachidonic acid (AA), one of the free fatty acids (FFA).
Positive_regulation (activates) of PLA2
11) Confidence 0.23 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2946038 Disease Relevance 0.33 Pain Relevance 0.07
The activation of PLA2 results in the genesis of arachidonic acid for prostaglandin production, which can be catalyzed via COX to produce PGE2 [32].
Positive_regulation (activation) of PLA2
12) Confidence 0.23 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 0.38 Pain Relevance 0.59
Cell swelling also activates phospholipase A2 (PLA2) and produces AA.
Positive_regulation (activates) of PLA2 associated with pressure and volume under development
13) Confidence 0.16 Published 2009 Journal Mol Pain Section Body Doc Link PMC2650694 Disease Relevance 1.40 Pain Relevance 0.64
The no activation of PLA2, stems for a relative preservation of cellular integrity, considering that PLA2 activation in anoxia may lead to cellular death through a caspase independent mechanism by inducing nuclear shrinkage [22].
Neg (no) Positive_regulation (activation) of PLA2 in stems associated with hypoxia and death
14) Confidence 0.08 Published 2006 Journal Respir Res Section Body Doc Link PMC1363731 Disease Relevance 0.62 Pain Relevance 0
In the latter case we found no increase in lysophospholipids, suggesting no activation of PLA2, a finding similar to that observed in cultured endothelial cells exposed to 3% O2 for 4 h [17].
Neg (no) Positive_regulation (activation) of PLA2 in endothelial cells
15) Confidence 0.08 Published 2006 Journal Respir Res Section Body Doc Link PMC1363731 Disease Relevance 0.61 Pain Relevance 0
The no activation of PLA2, stems for a relative preservation of cellular integrity, considering that PLA2 activation in anoxia may lead to cellular death through a caspase independent mechanism by inducing nuclear shrinkage [22].
Positive_regulation (activation) of PLA2 in stems associated with hypoxia and death
16) Confidence 0.08 Published 2006 Journal Respir Res Section Body Doc Link PMC1363731 Disease Relevance 0.62 Pain Relevance 0
Noninvasive determination of EF50 also showed that allergic mice were significantly more responsive to MCh, as indicated by significantly lower PD50 values for EF50 when compared with controls (P = 0.032) (Fig. 3).


Positive_regulation (values) of EF50 associated with hypersensitivity
17) Confidence 0.07 Published 2005 Journal Respir Res Section Body Doc Link PMC1316879 Disease Relevance 0.81 Pain Relevance 0.09
From these signals the parameters tidal midexpiratory flow (EF50), time of expiration (TE), tidal volume (VT) and respiratory rate (f) were calculated for each breath and were averaged in 5 s segments with a commercial software (HEM 3.4, Notocord, Paris, France).
Positive_regulation (averaged) of EF50 in Notocord
18) Confidence 0.07 Published 2005 Journal Respir Res Section Body Doc Link PMC1316879 Disease Relevance 0 Pain Relevance 0
Nevertheless, despite this variability, it is important to emphasize that the noninvasive measurement of EF50 still reflected the enhanced AR to A. fumigatus and MCh in allergic relative to control mice (Figs. 1, 3).
Positive_regulation (measurement) of EF50 associated with hypersensitivity
19) Confidence 0.07 Published 2005 Journal Respir Res Section Body Doc Link PMC1316879 Disease Relevance 0.50 Pain Relevance 0.05
From these signals the parameters tidal midexpiratory flow (EF50), time of expiration (TE), tidal volume (VT) and respiratory rate (f) were calculated for each breath and were averaged in 5 s segments with a commercial software (HEM 3.4, Notocord, Paris, France).
Positive_regulation (calculated) of EF50 in Notocord
20) Confidence 0.07 Published 2005 Journal Respir Res Section Body Doc Link PMC1316879 Disease Relevance 0 Pain Relevance 0

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