INT91238

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2000
Last Reported 2009
Negated 3
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.40
Pain Relevance 7.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
primary sensory neurons 2
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 133 100.00 Very High Very High Very High
mu opioid receptor 86 100.00 Very High Very High Very High
tolerance 59 100.00 Very High Very High Very High
Immobilon 16 100.00 Very High Very High Very High
MU agonist 7 100.00 Very High Very High Very High
antagonist 5 100.00 Very High Very High Very High
narcan 1 100.00 Very High Very High Very High
Opioid 54 99.80 Very High Very High Very High
Analgesic 26 99.32 Very High Very High Very High
Morphine 112 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Repression 8 100.00 Very High Very High Very High
Post Operative Pain 8 98.04 Very High Very High Very High
Bordatella Infection 1 97.24 Very High Very High Very High
Pain 5 90.80 High High
Herpes Simplex Virus Infection 5 90.20 High High
Contagious Ecthyma 14 47.40 Quite Low
Urological Neuroanatomy 12 5.00 Very Low Very Low Very Low
Drug Dependence 3 5.00 Very Low Very Low Very Low
Neuroblastoma 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mu-opioid receptor down-regulation and tolerance are not equally dependent upon G-protein signaling.
Neg (not) Regulation (dependent) of Negative_regulation (down-regulation) of Mu-opioid receptor associated with tolerance and opioid receptor
1) Confidence 0.45 Published 2002 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 11900797 Disease Relevance 0.10 Pain Relevance 1.11
The MOR uORF uses a mechanism independent of peptide sequence, and translational repression of MOR uORF is not dependent on the intercistronic region.
Neg (not) Regulation (dependent) of Negative_regulation (repression) of MOR uORF associated with repression and mu opioid receptor
2) Confidence 0.40 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.10 Pain Relevance 0.32
These results suggest that specific down-regulation of the mu-opioid receptor in the primary sensory neurons is responsible for the reduced analgesic action of morphine on postherpetic pain.
Regulation (responsible) of Negative_regulation (down-regulation) of mu-opioid receptor in primary sensory neurons associated with pain, post operative pain, analgesic, opioid receptor and morphine
3) Confidence 0.40 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17026987 Disease Relevance 1.20 Pain Relevance 2.21
These effects of opioids were not affected by either a MOR antagonist naloxone or a deletion of MOR gene.
Neg (not) Regulation (affected) of Negative_regulation (deletion) of MOR gene associated with antagonist, narcan, opioid receptor and opioid
4) Confidence 0.37 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19429017 Disease Relevance 0 Pain Relevance 2.04
This reduction of MOR-regulated transduction brought about a substantial decrease in the antinociceptive activity of the subsequent doses of the opioid.
Regulation (regulated) of Negative_regulation (reduction) of MOR associated with opioid and antinociceptive
5) Confidence 0.21 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0 Pain Relevance 1.08
Role of cAMP-dependent protein kinase (PKA) in opioid agonist-induced mu-opioid receptor downregulation and tolerance in mice.
Regulation (Role) of Negative_regulation (downregulation) of mu-opioid receptor associated with mu agonist, tolerance, opioid receptor and immobilon
6) Confidence 0.16 Published 2000 Journal Synapse Section Title Doc Link 11020235 Disease Relevance 0 Pain Relevance 1.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox