INT91271

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Context Info
Confidence 0.20
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6) methyltransferase activity (Mtr)
intracellular (Mtr) cytoplasm (Mtr)
Anatomy Link Frequency
macrophages 6
Mtr (Mus musculus)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 28 100.00 Very High Very High Very High
cytokine 8 100.00 Very High Very High Very High
opioid receptor 8 100.00 Very High Very High Very High
narcan 4 99.36 Very High Very High Very High
antagonist 4 99.18 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of this study suggest that methionine-enkephalin can modulate the proinflammatory cytokine response by controlling, via non-opioid receptor mechanism, the production of IL-6.
methionine-enkephalin Regulation (controlling) of Gene_expression (production) of IL-6 associated with opioid receptor, enkephalin and cytokine
1) Confidence 0.20 Published 2000 Journal Neuropeptides Section Abstract Doc Link 11021979 Disease Relevance 0 Pain Relevance 0.85
The effects of methionine-enkephalin on the production of interleukin-6 by activated peritoneal murine macrophages were studied.
methionine-enkephalin Regulation (effects) of Gene_expression (production) of interleukin-6 in macrophages associated with enkephalin
2) Confidence 0.20 Published 2000 Journal Neuropeptides Section Abstract Doc Link 11021979 Disease Relevance 0 Pain Relevance 0.61
The opioid receptor antagonist naloxone did not change the stimulatory effect of methionine-enkephalin on IL-6 production by stimulated macrophages.
methionine-enkephalin Regulation (effect) of Gene_expression (production) of IL-6 in macrophages associated with antagonist, narcan, enkephalin and opioid receptor
3) Confidence 0.20 Published 2000 Journal Neuropeptides Section Abstract Doc Link 11021979 Disease Relevance 0 Pain Relevance 0.88
Augmenting effect of methionine-enkephalin on interleukin-6 production by cytokine-stimulated murine macrophages.
methionine-enkephalin Regulation (effect) of Gene_expression (production) of interleukin-6 in macrophages associated with enkephalin and cytokine
4) Confidence 0.09 Published 2000 Journal Neuropeptides Section Title Doc Link 11021979 Disease Relevance 0 Pain Relevance 0.83

General Comments

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