INT91276

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Context Info
Confidence 0.27
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 3.11
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
brain 2
Cpox (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 17 100.00 Very High Very High Very High
COX2 4 99.96 Very High Very High Very High
Inflammatory response 4 99.80 Very High Very High Very High
Inflammation 29 99.64 Very High Very High Very High
acular 3 99.64 Very High Very High Very High
cOX1 2 99.64 Very High Very High Very High
aspirin 4 94.36 High High
antagonist 1 85.28 High High
Central nervous system 6 81.44 Quite High
cytokine 19 77.16 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 34 99.80 Very High Very High Very High
Colon Cancer 8 99.80 Very High Very High Very High
Cancer 12 97.64 Very High Very High Very High
Body Weight 2 90.76 High High
Disease 8 89.84 High High
Viral Meningitis 1 89.84 High High
Neurodegenerative Disease 1 89.04 High High
Immunotherapy Of Cancer 1 88.72 High High
Infection 35 88.68 High High
Vesicular Stomatitis 1 88.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro experiments showed that the effect of COX inhibition was at least partially mediated by increased production of Nitric Oxide (NO), a molecule known to inhibit VSV replication.
Spec (partially) Positive_regulation (mediated) of Negative_regulation (inhibition) of COX
1) Confidence 0.27 Published 2000 Journal Virology Section Abstract Doc Link 11021993 Disease Relevance 0.34 Pain Relevance 0.43
Inhibition of either COX enzyme led to decreases in BAL fluid levels of TNF-?
Positive_regulation (led) of Negative_regulation (Inhibition) of COX enzyme
2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904706 Disease Relevance 0.78 Pain Relevance 0.27
Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli.
Positive_regulation (increases) of Negative_regulation (inhibition) of COX in brain associated with inflammatory response and cox2
3) Confidence 0.22 Published 2005 Journal J. Neurochem. Section Title Doc Link 16277613 Disease Relevance 0.62 Pain Relevance 0.80
Cyclooxygenase (COX) inhibitors have antitumorigenic activity and increase the expression of the early growth response gene Egr-1, a tumor suppressor gene and transcription factor.
Positive_regulation (increase) of Negative_regulation (inhibitors) of COX associated with cancer
4) Confidence 0.20 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 16227405 Disease Relevance 0.40 Pain Relevance 0.16
Cyclo-oxygenase (COX)-2-specific inhibitors, which have an improved safety profile compared to traditional NSAIDs that inhibit both the COX-1 and COX-2 enzymes, seem to be well-suited drug candidates for CRC prevention.
Positive_regulation (candidates) of Negative_regulation (inhibitors) of COX associated with colon cancer and cinod
5) Confidence 0.03 Published 2005 Journal Recent Results Cancer Res. Section Abstract Doc Link 15648192 Disease Relevance 0.98 Pain Relevance 0.55

General Comments

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