INT9128

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Context Info
Confidence 0.62
First Reported 1982
Last Reported 2006
Negated 9
Speculated 4
Reported most in Abstract
Documents 27
Total Number 31
Disease Relevance 6.55
Pain Relevance 19.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
brain 10
medulla 6
dorsal 3
striatum 2
forebrain 2
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 181 100.00 Very High Very High Very High
Neuropeptide 31 100.00 Very High Very High Very High
Enkephalin 31 100.00 Very High Very High Very High
qutenza 18 100.00 Very High Very High Very High
substance P 16 100.00 Very High Very High Very High
Morphine 11 100.00 Very High Very High Very High
Somatostatin 11 100.00 Very High Very High Very High
Endogenous opioid 9 100.00 Very High Very High Very High
tolerance 5 100.00 Very High Very High Very High
Serotonin 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 4 99.90 Very High Very High Very High
INFLAMMATION 4 99.40 Very High Very High Very High
Gastric Motility Disorder 5 99.08 Very High Very High Very High
Lordosis 15 98.90 Very High Very High Very High
Nociception 4 97.96 Very High Very High Very High
Pancreatic Cancer 1 96.68 Very High Very High Very High
Urological Neuroanatomy 22 96.56 Very High Very High Very High
Schizophrenia 1 95.60 Very High Very High Very High
Disease 2 94.96 High High
Ulcers 1 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The distribution of receptor internalization surrounds the distribution of CCK cells in the medial preoptic nucleus, suggesting that endogenous opioid peptides may modulate estrogen-induced CCK mRNA expression.
Regulation (modulate) of Gene_expression (expression) of CCK mRNA in medial preoptic nucleus associated with endogenous opioid and cholecystokinin
1) Confidence 0.62 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9370197 Disease Relevance 0.24 Pain Relevance 1.36
These data suggest that regions outside the COOH terminus of rat CCK-58 influence the expression of CCK biological activity.
Regulation (influence) of Gene_expression (expression) of CCK
2) Confidence 0.62 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 14604858 Disease Relevance 0 Pain Relevance 0.07
The estrogenic induction of CCK mRNA appears to be dependent on estrogen sensitive pathways of neurotransmission, or components of second messenger pathways which regulate CCK mRNA expression in the adult limbic-hypothalamic lordosis regulating circuit, which are not functional before PND 18-25.
Regulation (regulate) of Gene_expression (expression) of CCK mRNA associated with lordosis and cholecystokinin
3) Confidence 0.62 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9482232 Disease Relevance 0.15 Pain Relevance 0.42
Neurohormonal regulation of pancreatic exocrine function in rats without gene expression of the cholecystokinin-A receptor.
Regulation (regulation) of Gene_expression (expression) of cholecystokinin associated with qutenza and cholecystokinin
4) Confidence 0.62 Published 1996 Journal Pancreas Section Title Doc Link 8830334 Disease Relevance 0.09 Pain Relevance 0.53
Reviews describe the regulation of CCK gene expression and CCK release, the nature of the hormone binding site of the CCK A receptor, interaction of CCK, dopamine and GABA, the role of CCK in thermoregulation, sexual behavior and satiety in rodents and humans.
Regulation (regulation) of Gene_expression (expression) of CCK associated with gaba and dopamine
5) Confidence 0.62 Published 2001 Journal Peptides Section Abstract Doc Link 11457511 Disease Relevance 0.13 Pain Relevance 0.23
Effect of capsaicin on cholecystokinin and neuropeptide Y expressions in the brain of high-fat diet fed rats.
Regulation (Effect) of Gene_expression (expressions) of cholecystokinin in brain associated with qutenza, neuropeptide and cholecystokinin
6) Confidence 0.54 Published 2004 Journal J. Vet. Med. Sci. Section Title Doc Link 15031536 Disease Relevance 0.32 Pain Relevance 0.91
The objective of these experiments was to examine the expression of CCK mRNA during postnatal development of this limbic-hypothalamic, lordosis regulating circuit, and to determine the age at which CCK mRNA expression becomes responsive to estrogen stimulation, by using quantitative in situ hybridization histochemistry.
Regulation (responsive) of Gene_expression (expression) of CCK mRNA associated with lordosis and cholecystokinin
7) Confidence 0.45 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9482232 Disease Relevance 0.19 Pain Relevance 0.49
RTX-treatment did not influence the expression of CCK mRNA in DRGs.
Neg (not) Regulation (influence) of Gene_expression (expression) of CCK mRNA associated with cholecystokinin
8) Confidence 0.45 Published 2000 Journal Pain Section Abstract Doc Link 10601669 Disease Relevance 0.55 Pain Relevance 0.86
Reviews describe the regulation of CCK gene expression and CCK release, the nature of the hormone binding site of the CCK A receptor, interaction of CCK, dopamine and GABA, the role of CCK in thermoregulation, sexual behavior and satiety in rodents and humans.
Regulation (regulation) of Gene_expression (expression) of CCK associated with gaba and dopamine
9) Confidence 0.45 Published 2001 Journal Peptides Section Abstract Doc Link 11457511 Disease Relevance 0.13 Pain Relevance 0.24
Because oestrogen is a powerful regulator of the expression of CCK and EOP, we examined whether oestrogen-state also modulated the interactions of these neuropeptides.
Regulation (regulator) of Gene_expression (expression) of CCK associated with neuropeptide and cholecystokinin
10) Confidence 0.45 Published 2002 Journal Pharmacol. Toxicol. Section Abstract Doc Link 12688384 Disease Relevance 0.19 Pain Relevance 0.69
Outgrowth of CCK and enkephalin reacting transplant fibers into the host brains was not observed in this study.
Neg (not) Regulation (observed) of Gene_expression (Outgrowth) of CCK in brains associated with enkephalin and cholecystokinin
11) Confidence 0.45 Published 1984 Journal J. Comp. Neurol. Section Abstract Doc Link 6480897 Disease Relevance 0 Pain Relevance 0.66
While increased enkephalin mRNA expression in the striatum ipsilateral to the lesion was detected, no change of cholecystokinin mRNA expression was observed in any forebrain on the lesioned side, suggesting that cholecystokinin expression in the forebrain is not under dopaminergic control.
Neg (no) Regulation (change) of Gene_expression (expression) of cholecystokinin in forebrain associated with enkephalin and cholecystokinin
12) Confidence 0.45 Published 1989 Journal Neuroscience Section Abstract Doc Link 2566954 Disease Relevance 0 Pain Relevance 0.68
Interaction of thyroxine and estrogen on the expression of estrogen receptor alpha, cholecystokinin, and preproenkephalin messenger ribonucleic acid in the limbic-hypothalamic circuit.
Regulation (Interaction) of Gene_expression (expression) of cholecystokinin associated with enkephalin and cholecystokinin
13) Confidence 0.44 Published 1998 Journal Endocrinology Section Title Doc Link 9492057 Disease Relevance 0.08 Pain Relevance 0.44
NOS expression in the subthalamic nucleus as well as tyrosine hydroxylase, GAD and CCK expression in the substantia nigra were unchanged.
Neg (unchanged) Regulation (unchanged) of Gene_expression (expression) of CCK in substantia nigra associated with generalized anxiety disorder, substantia nigra and cholecystokinin
14) Confidence 0.44 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12865138 Disease Relevance 0.52 Pain Relevance 0.79
Systemic administration of the gastrointestinal hormone cholecystokinin (CCK) selectively inhibits splanchnic sympathetic vasomotor discharge and differentially affects presympathetic vasomotor neurons of the rostroventrolateral medulla (RVLM).
Regulation (affects) of Gene_expression (administration) of CCK in medulla associated with medulla and cholecystokinin
15) Confidence 0.44 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12975810 Disease Relevance 0.32 Pain Relevance 0.42
Systemic administration of the gastrointestinal hormone cholecystokinin (CCK) selectively inhibits splanchnic sympathetic vasomotor discharge and differentially affects presympathetic vasomotor neurons of the rostroventrolateral medulla (RVLM).
Regulation (affects) of Gene_expression (administration) of gastrointestinal hormone cholecystokinin in medulla associated with medulla and cholecystokinin
16) Confidence 0.44 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12975810 Disease Relevance 0.32 Pain Relevance 0.42
Androgens regulate the sexually dimorphic production of co-contained galanin and cholecystokinin in lumbar laminae VII and X neurons.
Regulation (regulate) of Gene_expression (production) of cholecystokinin in neurons associated with cholecystokinin
17) Confidence 0.39 Published 2006 Journal Brain Res. Section Title Doc Link 16764834 Disease Relevance 0.08 Pain Relevance 0.25
To determine the effect of endogenous opioid input on estrogen-induced cholecystokinin, enkephalin and substance P expression, in situ hybridization histochemistry was used to examine estrogen-induced messenger RNA levels of these neuropeptides in specific nuclei of the limbic system and hypothalamus in the presence of opiate receptor antagonists.
Spec (determine) Regulation (effect) of Gene_expression (expression) of cholecystokinin in hypothalamus associated with antagonist, neuropeptide, endogenous opioid, opiate, enkephalin, limbic system, cholecystokinin and substance p
18) Confidence 0.37 Published 1997 Journal Neuroscience Section Abstract Doc Link 9284350 Disease Relevance 0.10 Pain Relevance 1.49
This enhanced response was not affected by simultaneous administration of cholecystokinin octapeptide (CCK-8).
Neg (not) Regulation (affected) of Gene_expression (administration) of CCK-8 associated with cholecystokinin
19) Confidence 0.36 Published 1985 Journal Peptides Section Abstract Doc Link 3162160 Disease Relevance 0 Pain Relevance 0.10
This enhanced response was not affected by simultaneous administration of cholecystokinin octapeptide (CCK-8).
Neg (not) Regulation (affected) of Gene_expression (administration) of cholecystokinin octapeptide associated with cholecystokinin
20) Confidence 0.36 Published 1985 Journal Peptides Section Abstract Doc Link 3162160 Disease Relevance 0 Pain Relevance 0.10

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