INT91284

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Context Info
Confidence 0.25
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.66
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry2) aging (P2ry2) plasma membrane (P2ry2)
embryo development (P2ry2) lysosome (P2ry2) signal transducer activity (P2ry2)
Anatomy Link Frequency
neurons 2
astrocytes 2
spinal cord 1
carotid body 1
microglia 1
P2ry2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 18 100.00 Very High Very High Very High
Neuropathic pain 8 99.64 Very High Very High Very High
Spinal cord 23 97.64 Very High Very High Very High
Glutamate 50 97.24 Very High Very High Very High
noradrenaline 24 95.88 Very High Very High Very High
dorsal root ganglion 8 95.20 Very High Very High Very High
Brush evoked pain 7 93.44 High High
medulla 13 91.92 High High
Analgesic 1 91.56 High High
Pain 5 91.08 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 18 99.64 Very High Very High Very High
Hypoxia 68 99.24 Very High Very High Very High
Ganglion Cysts 10 95.20 Very High Very High Very High
Pain 9 91.08 High High
Gliosis 12 90.24 High High
Headache 1 83.88 Quite High
Inflammatory Pain 1 82.92 Quite High
Nervous System Injury 9 82.48 Quite High
Syndrome 1 78.16 Quite High
Hypersensitivity 1 75.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In 1999, we demonstrated that exposure of rat primary astrocytes to NS-398, a selective inhibitor of the inducible mitogen-stimulated cyclooxygenase-2 (COX-2), significantly prevented P2Y receptor-mediated reactive astrogliosis [50].
Negative_regulation (prevented) of P2Y in astrocytes
1) Confidence 0.25 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 0.16 Pain Relevance 0.08
We also provide new original data showing a time-dependent downregulation of P2Y2 and P2Y4 receptor expression and function in purified SGCs cultures from TG, in comparison with primary mixed neuron-SGCs cultures.
Negative_regulation (downregulation) of P2Y2 in neuron
2) Confidence 0.23 Published 2010 Journal Neuron Glia Biol. Section Abstract Doc Link 20604978 Disease Relevance 0.55 Pain Relevance 0.56
The inhibitory effect of alpha,beta-MeATP was completely blocked by pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (3 x 10(-5) mol/L), a selective antagonist of the P2X > > P2Y receptor. 2.
Negative_regulation (antagonist) of P2Y receptor associated with antagonist
3) Confidence 0.21 Published 2000 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 11022968 Disease Relevance 0 Pain Relevance 0.10
Although our knowledge of their cell-specific localization at the protein level is still incomplete, it appears that a number of them, such as P2Y1, P2Y2, and P2Y6 receptors, are expressed both on neurons and astrocytes [90–96], whereas others are not exclusively, but predominantly localized to astrocytes (P2Y13: [97] P2Y14: [98]), oligodendrocytes (P2Y12: [99]], or microglia (P2Y12: [100]).
Negative_regulation (number) of P2Y2 in astrocytes
4) Confidence 0.18 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072919 Disease Relevance 0 Pain Relevance 0.10
Together, our findings indicate that activation of P2Y(12)Rs in spinal microglia may be a critical event in the pathogenesis of neuropathic pain and suggest that blocking microglial P2Y(12)R might be a viable therapeutic strategy for treating neuropathic pain.
Negative_regulation (blocking) of P2Y in microglia associated with neuropathic pain
5) Confidence 0.17 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18463248 Disease Relevance 1.16 Pain Relevance 0.94
Although our knowledge of their cell-specific localization at the protein level is still incomplete, it appears that a number of them, such as P2Y1, P2Y2, and P2Y6 receptors, are expressed both on neurons and astrocytes [90–96], whereas others are not exclusively, but predominantly localized to astrocytes (P2Y13: [97] P2Y14: [98]), oligodendrocytes (P2Y12: [99]], or microglia (P2Y12: [100]).
Negative_regulation (number) of P2Y2 in neurons
6) Confidence 0.06 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072919 Disease Relevance 0 Pain Relevance 0.10
In conclusion, inhibitory P2Y and facilitatory P2X1-like receptors, involved in the regulation of glutamate (P2Y13 and/or P2Y1) and noradrenaline (P2Y13 and/or P2Y1, P2Y12) release have been identified, which provide novel target sites for analgesics acting at the spinal cord level.
Negative_regulation (inhibitory) of P2Y in spinal cord associated with glutamate, analgesic, noradrenaline and spinal cord
7) Confidence 0.03 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18063000 Disease Relevance 0.10 Pain Relevance 0.77
In addition, the hypoxia-induced NO production was reduced by blockade of P2X/P2Y purinoceptors in the carotid body.
Negative_regulation (blockade) of P2Y in carotid body associated with hypoxia
8) Confidence 0.01 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.69 Pain Relevance 0.07

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