INT91285

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 29
Total Number 30
Disease Relevance 12.74
Pain Relevance 15.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx2)
Anatomy Link Frequency
DRG 4
nerve 3
neurons 3
carotid body 2
oocytes 1
P2rx2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 104 100.00 Very High Very High Very High
antagonist 103 100.00 Very High Very High Very High
Hippocampus 28 100.00 Very High Very High Very High
Morphine 14 100.00 Very High Very High Very High
Analgesic 13 100.00 Very High Very High Very High
Root ganglion neuron 1 100.00 Very High Very High Very High
dorsal root ganglion 57 99.84 Very High Very High Very High
dexamethasone 3 99.70 Very High Very High Very High
Eae 22 99.68 Very High Very High Very High
Pain 41 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 59 100.00 Very High Very High Very High
Colitis 7 100.00 Very High Very High Very High
Convulsion 6 100.00 Very High Very High Very High
Injury 31 99.68 Very High Very High Very High
Muscle Weakness 2 99.68 Very High Very High Very High
Pain 37 99.32 Very High Very High Very High
Hypoxia 134 99.24 Very High Very High Very High
Nervous System Injury 7 98.88 Very High Very High Very High
Cystitis 2 98.20 Very High Very High Very High
Nociception 40 96.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hence, alpha,beta-meATP-sensitive P2X3 and/or P2X2/3 receptors of L6/S1 dorsal root ganglion neurons were functionally downregulated during subacute pain caused by experimental cystitis.
Negative_regulation (downregulated) of P2X2 in dorsal root ganglion associated with ganglion cysts, pain, root ganglion neuron and cystitis
1) Confidence 0.57 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12909197 Disease Relevance 0.69 Pain Relevance 0.68
In addition, about 25% of the distension-evoked pelvic nerve discharge could be blocked with P2X receptor antagonists.
Negative_regulation (blocked) of P2X in nerve associated with antagonist
2) Confidence 0.35 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2104004 Disease Relevance 0.12 Pain Relevance 0.15
hydroxylation by suppressing PAH activity under normoxic conditions, closely mimic the effect of acute hypoxia on the NO production in the carotid body; (2) blockade of P2X and/or P2Y purinoceptors attenuated the effect of acute hypoxia on the NO production in the carotid body.
Negative_regulation (blockade) of P2X in carotid body associated with hypoxia
3) Confidence 0.34 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.68 Pain Relevance 0
In addition, the hypoxia-induced NO production was reduced by blockade of P2X/P2Y purinoceptors in the carotid body.
Negative_regulation (blockade) of P2X in carotid body associated with hypoxia
4) Confidence 0.33 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.69 Pain Relevance 0.07
In the present study, we confirm that site-directed elimination of the potential phosphor-acceptor threonine or the basic residue in the P+2 position of the TXR/K sequence accelerates desensitization of P2X2 receptors and abolishes P2X3 receptor function.
Negative_regulation (desensitization) of P2X2
5) Confidence 0.31 Published 2007 Journal Purinergic Signal Section Abstract Doc Link PMC2072911 Disease Relevance 0.28 Pain Relevance 0.28
Trivalent cations can also have a regulatory role inhibiting P2X receptor function (Nakazawa et al., 1997).
Negative_regulation (inhibiting) of P2X
6) Confidence 0.27 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2972645 Disease Relevance 0 Pain Relevance 0.07
These results suggest that A-317491 is a peripherally acting P2X blocker.
Negative_regulation (blocker) of P2X
7) Confidence 0.27 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15507220 Disease Relevance 0.51 Pain Relevance 0.73
However, neither the VMR nor the P2X(3) mRNA level in DRG from OVX colitis rats was reversed by the complex of estrogen and progesterone.
Negative_regulation (reversed) of P2X in DRG associated with colitis
8) Confidence 0.21 Published 2009 Journal Steroids Section Abstract Doc Link 19628002 Disease Relevance 0.59 Pain Relevance 0.14
A-317491 was identified as a specific inhibitor for P2X2/3 and P2X3 receptors.
Negative_regulation (inhibitor) of P2X2
9) Confidence 0.20 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.57 Pain Relevance 0.57
After nerve injury, the mRNA of P2X(5) was increased, those of P2X(3) and P2X(6) were decreased, and those of P2X(2) and P2X(4) were unchanged.
Negative_regulation (decreased) of P2X in nerve associated with nervous system injury
10) Confidence 0.20 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12527393 Disease Relevance 0.33 Pain Relevance 0.27
P2X2 and P2X4 receptor expression in the hippocampus of seizure-prone gerbils was significantly reduced compared with that of normal gerbils [139].
Negative_regulation (reduced) of P2X2 in hippocampus associated with convulsion and hippocampus
11) Confidence 0.20 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.87 Pain Relevance 0.48
Lanthanum and gadolinium blocked P2X1 and P2X2 currents in oocytes; this inhibition appeared competitive and was reversed by increasing the ATP concentration (Nakazawa et al., 1997).
Negative_regulation (blocked) of P2X2 in oocytes
12) Confidence 0.17 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2972645 Disease Relevance 0 Pain Relevance 0.06
These behavioral effects were significantly correlated with a decrease in P2X(3) receptor protein expression in the dorsal root ganglia (DRG).
Negative_regulation (decrease) of P2X in DRG
13) Confidence 0.16 Published 2002 Journal Pain Section Abstract Doc Link 12237180 Disease Relevance 1.14 Pain Relevance 0.96
The injection and incubation procedure induced a small non-significant decrease in P2X2/3 current amplitude (Fig. 3C).


Negative_regulation (decrease) of P2X2
14) Confidence 0.12 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0 Pain Relevance 0
At P2X2 and P2X4 receptors the response was inhibited by MTSES.
Negative_regulation (inhibited) of P2X2
15) Confidence 0.11 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2459275 Disease Relevance 0 Pain Relevance 0.31
These results suggest that, while there appears to be a decrease in fast desensitizing P2X(3) receptors following L5/L6 nerve ligation injury, certain subsets of small and large DRG neurons maintain normal P2X(3) receptor expression and function.
Negative_regulation (decrease) of P2X in nerve associated with injury
16) Confidence 0.09 Published 2002 Journal Exp Brain Res Section Abstract Doc Link 12444483 Disease Relevance 0.29 Pain Relevance 0.51
In vitro electrophysiological analysis of acutely isolated DRG neurons revealed a similar decrease in functional P2X(3)-containing receptors.
Negative_regulation (decrease) of P2X in neurons
17) Confidence 0.09 Published 2002 Journal Exp Brain Res Section Abstract Doc Link 12444483 Disease Relevance 0.38 Pain Relevance 0.57
Intrathecal administration of Brilliant Blue G (BBG), a selective P2X(7)R inhibitor, significantly attenuated the loss of morphine analgesic potency, P2X(7)R upregulation, and microglial activation.
Negative_regulation (inhibitor) of P2X associated with analgesic, potency, morphine and intrathecal
18) Confidence 0.08 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20534852 Disease Relevance 0.09 Pain Relevance 1.41
Intrathecal administration of Brilliant Blue G (BBG), a selective P2X(7)R inhibitor, significantly attenuated the loss of morphine analgesic potency, P2X(7)R upregulation, and microglial activation.
Negative_regulation (loss) of P2X associated with analgesic, potency, morphine and intrathecal
19) Confidence 0.07 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20534852 Disease Relevance 0.09 Pain Relevance 1.43
We disclose the design of a novel series of cyanoguanidines that are potent (IC(50) approximately 10-100 nM) and selective (> or = 100-fold) P2X(7) receptor antagonists against the other P2 receptor subtypes such as the P2Y(2), P2X(4), and P2X(3).
Negative_regulation (antagonists) of P2X associated with antagonist
20) Confidence 0.07 Published 2009 Journal J. Med. Chem. Section Abstract Doc Link 19397270 Disease Relevance 0.25 Pain Relevance 0.57

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