INT913

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Context Info
Confidence 0.62
First Reported 1979
Last Reported 2010
Negated 16
Speculated 5
Reported most in Abstract
Documents 71
Total Number 76
Disease Relevance 8.64
Pain Relevance 32.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PLOD1) endoplasmic reticulum (PLOD1)
Anatomy Link Frequency
pituitary 10
gonadal 8
brain 4
plasma 2
egg 2
PLOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 283 100.00 Very High Very High Very High
Opioid 68 100.00 Very High Very High Very High
opiate 67 100.00 Very High Very High Very High
Endogenous opioid 54 100.00 Very High Very High Very High
Dopamine 36 100.00 Very High Very High Very High
ketamine 22 100.00 Very High Very High Very High
fluoxetine 20 100.00 Very High Very High Very High
Serotonin 15 100.00 Very High Very High Very High
Enkephalin 15 99.78 Very High Very High Very High
antagonist 433 99.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 22 100.00 Very High Very High Very High
Endometriosis (extended) 114 99.64 Very High Very High Very High
Lifespan 8 99.60 Very High Very High Very High
Galactorrhea 9 99.32 Very High Very High Very High
Polycystic Ovary Syndrome 103 99.28 Very High Very High Very High
Disease 38 98.96 Very High Very High Very High
Syndrome 24 98.92 Very High Very High Very High
Aging 49 98.28 Very High Very High Very High
Hypoglycemia 11 98.04 Very High Very High Very High
Precocious Puberty 10 97.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Opioid control of LH secretion in humans: menstrual cycle, menopause and aging reduce effect of naloxone but not of morphine.
Regulation (control) of Localization (secretion) of LH associated with aging, endometriosis (extended), narcan, opioid and morphine
1) Confidence 0.62 Published 1986 Journal Life Sci. Section Title Doc Link 3086650 Disease Relevance 0.20 Pain Relevance 0.83
These results indicate that in humans there is a change in the activity of the opioids regulating LH secretion during the menstrual cycle, after menopause and in aged men and that these may be studied by the use of naloxone.
Regulation (regulating) of Localization (secretion) of LH associated with endometriosis (extended), narcan and opioid
2) Confidence 0.62 Published 1986 Journal Life Sci. Section Abstract Doc Link 3086650 Disease Relevance 0.25 Pain Relevance 0.90
These data indicate that the central opioid system regulating LH secretion in humans is active only at more advanced stages of puberty and it does not seem to play a role in the beginning of sexual maturation.
Regulation (regulating) of Localization (secretion) of LH associated with opioid
3) Confidence 0.62 Published 1986 Journal Acta Endocrinol Suppl (Copenh) Section Abstract Doc Link 3465161 Disease Relevance 1.03 Pain Relevance 0.46
Before veralipride administration, the naloxone infusion did not alter LH secretion.
Neg (not) Regulation (alter) of Localization (secretion) of LH associated with narcan
4) Confidence 0.62 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2834413 Disease Relevance 0 Pain Relevance 0.39
The effects of sulpiride and naloxone on the changes in LH secretion induced by a metenkephalin analog (D-Ala2-MePhe4-Met-(o)-ol-Enkephalin, FK 33824, Sandoz, Basel, Switzerland) (DAMME) and dopamine infusion in four castrated men (21 to 25 years of age) were studied.
Regulation (effects) of Localization (secretion) of LH associated with dopamine, narcan and enkephalin
5) Confidence 0.61 Published 1985 Journal Fertil. Steril. Section Abstract Doc Link 4054321 Disease Relevance 0 Pain Relevance 0.51
These findings confirm that central dopaminergic and opiatergic systems play a role in the control of LH secretion; the data also exclude any interaction between these systems in regulating LH secretion.
Regulation (role) of Localization (secretion) of LH
6) Confidence 0.61 Published 1985 Journal Fertil. Steril. Section Abstract Doc Link 4054321 Disease Relevance 0 Pain Relevance 0.48
These findings confirm that central dopaminergic and opiatergic systems play a role in the control of LH secretion; the data also exclude any interaction between these systems in regulating LH secretion.
Regulation (regulating) of Localization (secretion) of LH
7) Confidence 0.61 Published 1985 Journal Fertil. Steril. Section Abstract Doc Link 4054321 Disease Relevance 0 Pain Relevance 0.46
Brain noradrenergic mechanisms participate in the excitatory control of episodic LH release in many experimental animals, including the nonhuman primate.
Regulation (control) of Localization (release) of LH in Brain
8) Confidence 0.61 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6313736 Disease Relevance 0 Pain Relevance 0.21
We conclude that in the doses used, phenoxybenzamine and alpha-methyldopa do not alter spontaneous or opiate-modulated episodic LH release in normal men.
Neg (not) Regulation (alter) of Localization (release) of LH associated with opiate
9) Confidence 0.61 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6313736 Disease Relevance 0 Pain Relevance 0.28
Endogenous opioid-like peptides influence gonadotropin release in adult animals and man; however, the role of these peptides in the regulation of fetal LH secretion is not known.
Regulation (role) of Localization (secretion) of LH associated with endogenous opioid
10) Confidence 0.61 Published 1985 Journal Endocrinology Section Abstract Doc Link 3987627 Disease Relevance 0 Pain Relevance 0.48
After the administration of naloxone, LH secretion increased from 38.6 +/- 5.8 to 114 +/- 21 ng/h ml-1 (P less than 0.001); LH release was not affected by administration of the vehicle.
Neg (not) Regulation (affected) of Localization (release) of LH associated with narcan
11) Confidence 0.61 Published 1985 Journal Endocrinology Section Abstract Doc Link 3987627 Disease Relevance 0 Pain Relevance 0.73
Opiates increase hypothalamic serotonin turnover but the involvement of the serotoninergic system in the opioid mechanisms regulating LH secretion in man is not clear at present.
Regulation (regulating) of Localization (secretion) of LH associated with opiate, opioid and serotonin
12) Confidence 0.61 Published 1986 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 3621624 Disease Relevance 0 Pain Relevance 0.63
These data suggest that in man a hypothalamic serotoninergic system may be involved in the opioid mechanisms regulating LH secretion.
Regulation (regulating) of Localization (secretion) of LH associated with opioid
13) Confidence 0.61 Published 1986 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 3621624 Disease Relevance 0 Pain Relevance 0.67
Furthermore, the results suggest that opioid regulation of LH secretion in humans changes during puberty, reaching an adult-like functional state with maturation of the hypothalamus-pituitary-gonadal axis.
Regulation (regulation) of Localization (secretion) of LH in gonadal associated with opioid
14) Confidence 0.61 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3531220 Disease Relevance 0.61 Pain Relevance 0.25
The aim of the present study was to evaluate the activity of opiate receptors involved in the control of LH secretion during pubertal development, as determined by the LH response to naloxone.
Regulation (control) of Localization (secretion) of LH associated with narcan and opiate
15) Confidence 0.61 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3531220 Disease Relevance 0.32 Pain Relevance 0.22
The naloxone-induced LH increase is not observed before pubertal maturation, in both sexes, and is absent in children with delayed or precocious puberty and in those with Klinefelter's or Turner's syndrome, suggesting a role of gonadal function on the opioid control of LH secretion.
Regulation (control) of Localization (secretion) of LH in gonadal associated with precocious puberty, syndrome, narcan and opioid
16) Confidence 0.60 Published 1989 Journal J. Steroid Biochem. Section Abstract Doc Link 2689783 Disease Relevance 0.20 Pain Relevance 0.63
The inhibitory role of the dopaminergic and opioidergic mechanisms in the control of LH secretion in patients with polycystic ovary syndrome (PCO) was evaluated.
Regulation (control) of Localization (secretion) of LH in ovary associated with polycystic ovary syndrome
17) Confidence 0.58 Published 1984 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 6088126 Disease Relevance 0.35 Pain Relevance 0.62
The observation that hypoglycemia inhibited LH levels only during a period of restraint suggests either an additive or synergistic effect of these two stresses on LH secretion.
Regulation (effect) of Localization (secretion) of LH associated with stress and hypoglycemia
18) Confidence 0.58 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8388404 Disease Relevance 0.57 Pain Relevance 0.36
In the postmenopausal period, naloxone has no effect on LH release; estrogen/progestin therapy does restore the LH response.
Neg (no) Regulation (effect) of Localization (release) of LH associated with narcan
19) Confidence 0.56 Published 1992 Journal Psychoneuroendocrinology Section Abstract Doc Link 1359605 Disease Relevance 0 Pain Relevance 0.28
In particular, these peptides control the secretion of LH by inhibiting the activity of the hypothalamic neurons which produce GnRH.
Regulation (control) of Localization (secretion) of LH in neurons
20) Confidence 0.56 Published 1992 Journal Psychoneuroendocrinology Section Abstract Doc Link 1359605 Disease Relevance 0 Pain Relevance 0.28

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