INT91305

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Context Info
Confidence 0.31
First Reported 2000
Last Reported 2003
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0.64
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npff) extracellular region (Npff) plasma membrane (Npffr2)
signal transducer activity (Npffr2)
Npff (Rattus norvegicus)
Npffr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
central nervous system 2 99.60 Very High Very High Very High
Neuropeptide 17 96.52 Very High Very High Very High
tolerance 1 95.32 Very High Very High Very High
opiate 1 94.92 High High
pain 5 94.04 High High
Dorsal horn 1 85.68 High High
spinal cord 1 84.16 Quite High
Cholecystokinin 1 63.44 Quite High
Disease Link Frequency Relevance Heat
Pain 5 94.04 High High
Body Weight 3 68.56 Quite High
Eating Disorder 3 64.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that orexins interact with the NPGPR and that the affinity of NPFF for NPGPR is approximately 100-fold lower than for the NPFF2 receptor.
NPFF Binding (affinity) of NPGPR
1) Confidence 0.31 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12609745 Disease Relevance 0.19 Pain Relevance 0.23
We conclude that orexins interact with the NPGPR and that the affinity of NPFF for NPGPR is approximately 100-fold lower than for the NPFF2 receptor.
NPFF Binding (affinity) of NPFF2
2) Confidence 0.24 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12609745 Disease Relevance 0.20 Pain Relevance 0.23
Therefore, we used binding studies to examine the interaction of NPFF, orexin and NPY with the NPGPR. [125I] NPFF was displaced by NPFF with an IC(50) of 14.7 +/- 8.8 nM, whereas [125I] Orexin B was displaced by Orexin B with an IC(50) of 415 +/- 195 nM.
NPFF Spec (examine) Binding (interaction) of NPGPR
3) Confidence 0.21 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12609745 Disease Relevance 0.08 Pain Relevance 0.26
NPFF specifically bound to NPFF1 (K(d) = 1.13 nm) and NPFF2 (K(d) = 0.37 nm), and both receptors were activated by NPFF in a variety of heterologous expression systems.
NPFF Binding (bound) of NPFF2
4) Confidence 0.19 Published 2000 Journal J. Biol. Chem. Section Abstract Doc Link 11024015 Disease Relevance 0.17 Pain Relevance 0.61

General Comments

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