INT9131

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2010
Negated 12
Speculated 23
Reported most in Abstract
Documents 431
Total Number 454
Disease Relevance 130.80
Pain Relevance 302.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
neurons 29
spinal cord 26
spinal 15
spinal cord dorsal horn 12
neuronal 10
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 5601 100.00 Very High Very High Very High
dorsal root ganglion 1414 100.00 Very High Very High Very High
Spinal cord 1245 100.00 Very High Very High Very High
Morphine 1081 100.00 Very High Very High Very High
nMDA receptor 709 100.00 Very High Very High Very High
Glutamate receptor 417 100.00 Very High Very High Very High
nav1.8 267 100.00 Very High Very High Very High
Neuropathic pain 230 100.00 Very High Very High Very High
Dorsal horn 222 100.00 Very High Very High Very High
Neurotransmitter 143 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1536 100.00 Very High Very High Very High
Neuropathic Pain 411 100.00 Very High Very High Very High
Lung Injury 49 100.00 Very High Very High Very High
Nociception 726 99.98 Very High Very High Very High
Hypoxia 97 99.98 Very High Very High Very High
Sepsis 42 99.98 Very High Very High Very High
Hyperalgesia 972 99.92 Very High Very High Very High
Adult Respiratory Distress Syndrome 260 99.90 Very High Very High Very High
Targeted Disruption 254 99.88 Very High Very High Very High
Diabetes Mellitus 510 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both the development of thermal hyperalgesia and the increase in PKC gamma immunoreactivity in CCI rats were prevented by once daily intrathecal administration with 10 nmol MK-801 for 7 days.
Positive_regulation (increase) of PKC associated with nervous system injury, thermal hyperalgesia and intrathecal
1) Confidence 0.70 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 8592645 Disease Relevance 0.62 Pain Relevance 0.67
Such PKC gamma immunostaining was observed primarily in neuronal somata (ipsilateral > contralateral, laminae I-II > III-IV), indicating postsynaptic sites of PKC gamma increases.
Positive_regulation (increases) of PKC in neuronal
2) Confidence 0.70 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 8592645 Disease Relevance 0.62 Pain Relevance 0.67
Consistent with behavioral changes, CCI rats examined 3 or 10 days after sciatic nerve ligation displayed a three-dimensional pattern of increased membrane-bound PKC in the lumbar spinal cord (L1-L5) strikingly different from that of sham-operated rats: in the dorsoventral dimension, reliable increases in membrane-bound PKC occurred mainly within spinal cord laminae I-IV and V-VI in CCI rats; in the ipsilateral-contralateral dimension, changes in membrane-bound PKC were seen on both sides of the spinal cord in CCI rats with reliably higher levels of membrane-bound PKC on the side ipsilateral than on the side contralateral to sciatic nerve ligation; in the rostrocaudal dimension, increases in membrane-bound PKC in the spinal cord dorsal horns of CCI rats extended from spinal segments L2-L5. 4.
Positive_regulation (increased) of PKC in spinal cord associated with kinase c, nervous system injury, sciatic nerve and spinal cord
3) Confidence 0.70 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8410149 Disease Relevance 0.96 Pain Relevance 1.28
Consistent with behavioral changes, CCI rats examined 3 or 10 days after sciatic nerve ligation displayed a three-dimensional pattern of increased membrane-bound PKC in the lumbar spinal cord (L1-L5) strikingly different from that of sham-operated rats: in the dorsoventral dimension, reliable increases in membrane-bound PKC occurred mainly within spinal cord laminae I-IV and V-VI in CCI rats; in the ipsilateral-contralateral dimension, changes in membrane-bound PKC were seen on both sides of the spinal cord in CCI rats with reliably higher levels of membrane-bound PKC on the side ipsilateral than on the side contralateral to sciatic nerve ligation; in the rostrocaudal dimension, increases in membrane-bound PKC in the spinal cord dorsal horns of CCI rats extended from spinal segments L2-L5. 4.
Positive_regulation (increases) of PKC in spinal cord dorsal horns associated with kinase c, nervous system injury, sciatic nerve and spinal cord
4) Confidence 0.70 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8410149 Disease Relevance 0.99 Pain Relevance 1.34
This three-dimensional increase in membrane-bound PKC in the spinal cord dorsal horn of CCI rats displayed high correlations with thermal hyperalgesia and with spontaneous pain-related behaviors in CCI rats observed both 3 and 10 days after sciatic nerve ligation.
Positive_regulation (increase) of PKC in spinal cord dorsal horn associated with pain, kinase c, nervous system injury, thermal hyperalgesia, spontaneous pain, dorsal horn, sciatic nerve and spinal cord
5) Confidence 0.70 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8410149 Disease Relevance 1.01 Pain Relevance 1.44
Consistent with behavioral changes, CCI rats examined 3 or 10 days after sciatic nerve ligation displayed a three-dimensional pattern of increased membrane-bound PKC in the lumbar spinal cord (L1-L5) strikingly different from that of sham-operated rats: in the dorsoventral dimension, reliable increases in membrane-bound PKC occurred mainly within spinal cord laminae I-IV and V-VI in CCI rats; in the ipsilateral-contralateral dimension, changes in membrane-bound PKC were seen on both sides of the spinal cord in CCI rats with reliably higher levels of membrane-bound PKC on the side ipsilateral than on the side contralateral to sciatic nerve ligation; in the rostrocaudal dimension, increases in membrane-bound PKC in the spinal cord dorsal horns of CCI rats extended from spinal segments L2-L5. 4.
Positive_regulation (increases) of PKC in spinal cord associated with kinase c, nervous system injury, sciatic nerve and spinal cord
6) Confidence 0.70 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8410149 Disease Relevance 1.10 Pain Relevance 1.41
Both three-dimensional increases in spinal cord membrane-bound PKC and nociceptive behaviors (thermal hyperalgesia and spontaneous pain behaviors) in CCI rats were reliably reduced after three daily intrathecal treatments with 80 nmol GM1 ganglioside (a glycosphingolipid shown to prevent PKC translocation/activation), the first of which was given 1 h after sciatic nerve ligation.
Positive_regulation (increases) of PKC in spinal cord associated with pain, nociception, spinal cord, kinase c, nervous system injury, thermal hyperalgesia, spontaneous pain, sciatic nerve and intrathecal
7) Confidence 0.70 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8410149 Disease Relevance 1.21 Pain Relevance 1.49
In addition, spinal cord administration of GM1 ganglioside, an intracellular inhibitor of PKC translocation/activation, reverses both increased levels of membrane-bound PKC and pain-related behaviors.
Positive_regulation (increased) of PKC in spinal cord associated with pain, kinase c and spinal cord
8) Confidence 0.70 Published 1992 Journal Brain Res. Section Abstract Doc Link 1393564 Disease Relevance 0.77 Pain Relevance 0.92
Thus, persistent post-injury neuropathic pain may be mediated by the initiation of excitatory neuropathological processes resulting from an increase in membrane-bound PKC.
Positive_regulation (increase) of PKC associated with kinase c, injury and neuropathic pain
9) Confidence 0.70 Published 1992 Journal Brain Res. Section Abstract Doc Link 1393564 Disease Relevance 0.74 Pain Relevance 0.88
This study provides evidence that induction and/or maintenance of post-injury neuropathic pain behaviors in the rat is associated with increases in membrane-bound protein kinase C (PKC), a Ca(2+)-dependent process known to mediate central nervous system neuronal plasticity.
Positive_regulation (increases) of PKC in neuronal associated with kinase c, injury, neuropathic pain and central nervous system
10) Confidence 0.70 Published 1992 Journal Brain Res. Section Abstract Doc Link 1393564 Disease Relevance 0.76 Pain Relevance 0.89
Moreover, both the development of morphine tolerance and the increase in PKC gamma immunoreactivity were prevented by co-administration of morphine with 10 nmol MK-801 between Day 2 and Day 7 of the eight day treatment schedule.
Positive_regulation (increase) of PKC gamma associated with kinase c, tolerance and morphine
11) Confidence 0.70 Published 1995 Journal Brain Res. Section Abstract Doc Link 7552251 Disease Relevance 0 Pain Relevance 2.22
In contrast, PKC gamma immunoreactivity was not increased in rats receiving a single i.t. administration of 10 micrograms morphine on Day 8, nor did repeated treatment with 10 nmol MK-801 alone change baseline levels of PKC gamma immunoreactivity.
Neg (not) Positive_regulation (increased) of PKC gamma associated with kinase c and morphine
12) Confidence 0.70 Published 1995 Journal Brain Res. Section Abstract Doc Link 7552251 Disease Relevance 0 Pain Relevance 2.15
In association with the development of tolerance to morphine analgesia induced by once daily intrathecal administration of 10 micrograms morphine for eight days, PKC gamma immunoreactivity was clearly increased in the spinal cord dorsal horn of these same rats.
Positive_regulation (increased) of PKC gamma in spinal cord dorsal horn associated with kinase c, dorsal horn, tolerance, spinal cord, intrathecal, analgesia and morphine
13) Confidence 0.70 Published 1995 Journal Brain Res. Section Abstract Doc Link 7552251 Disease Relevance 0 Pain Relevance 2.10
In addition, intracellular perfusion with 5 mM bis-(o-aminophenoxy)-N,N,N',N'-tetraacetic acid (BAPTA) or pretreatment with omega-conotoxin GVIA or Cd(2+)-Ringer, but not nifedipine, prevented the PDBu-induced suppression of I(K) at -50 mV, suggesting that a voltage-dependent influx of calcium through N-type calcium channels was necessary for the activation of PKC.
Positive_regulation (activation) of PKC associated with kinase c, calcium channel and conotoxin
14) Confidence 0.70 Published 2001 Journal J. Neurophysiol. Section Abstract Doc Link 11152736 Disease Relevance 0 Pain Relevance 0.42
We find that activation of PKC inhibits I(K) in rat sensory neurons and that voltage-dependent calcium entry is necessary for the development and maintenance of this inhibition.
Positive_regulation (activation) of PKC in sensory neurons associated with kinase c
15) Confidence 0.70 Published 2001 Journal J. Neurophysiol. Section Abstract Doc Link 11152736 Disease Relevance 0 Pain Relevance 0.27
I.t. morphine infusion, but not saline, produced a 2-fold increase in dorsal horn PKC phosphorylating activity and in the expression of PKCalpha/gamma.
Positive_regulation (increase) of PKC in dorsal horn associated with kinase c, dorsal horn and morphine
16) Confidence 0.70 Published 2000 Journal Pain Section Abstract Doc Link 10781912 Disease Relevance 0 Pain Relevance 1.86
Bolus chelerythrine on d5 after spinal morphine infusion blocked upon an increase in PKC activity, confirming that at the behaviorally active dose the drug had the intended biochemical effect upon spinal PKC activity.
Positive_regulation (increase) of PKC in spinal associated with kinase c and morphine
17) Confidence 0.70 Published 2000 Journal Pain Section Abstract Doc Link 10781912 Disease Relevance 0 Pain Relevance 1.85
Our experimental results suggested that activation of PKC locks synaptic GABA(A)Rs in a functional state precluding further positive allosteric modulation by endogenous and exogenous 3alpha5alphaNS.
Positive_regulation (activation) of PKC associated with gaba and kinase c
18) Confidence 0.70 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17767496 Disease Relevance 0.30 Pain Relevance 1.11
Using patch-clamp recordings of lamina II interneurones in the spinal cord of 15-20-day-old rats, we showed that synaptic inhibition mediated by GABA(A)Rs and its modulation by 3alpha5alphaNS in lamina II of the spinal cord largely depend on activation of PKC.
Positive_regulation (activation) of PKC in lamina associated with kinase c, gaba and spinal cord
19) Confidence 0.70 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17767496 Disease Relevance 0.31 Pain Relevance 1.10
These results suggest that chronic morphine administration leads to an upregulation of the cytosolic PKC activity in the pons/medulla through repeated activation of mu opioid receptors and that the PKC upregulation in this specific area may contribute to the morphine tolerance.
Positive_regulation (upregulation) of PKC in medulla associated with medulla, kinase c, tolerance, mu opioid receptor and morphine
20) Confidence 0.70 Published 1994 Journal Brain Res. Section Abstract Doc Link 7953672 Disease Relevance 0 Pain Relevance 2.01

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