INT91311

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Context Info
Confidence 0.45
First Reported 2000
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.89
Pain Relevance 2.58

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plasma membrane (Grm2) intracellular (Grm2) signal transducer activity (Grm2)
Anatomy Link Frequency
cerebral cortex 1
brain 1
Grm2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 53 100.00 Very High Very High Very High
antagonist 24 100.00 Very High Very High Very High
Glutamate receptor 15 100.00 Very High Very High Very High
Spinal cord 2 99.40 Very High Very High Very High
cerebral cortex 2 98.96 Very High Very High Very High
Hippocampus 9 97.72 Very High Very High Very High
addiction 6 94.92 High High
Dopamine 24 93.08 High High
analgesia 9 92.76 High High
Neurotransmitter 2 92.16 High High
Disease Link Frequency Relevance Heat
Drug Dependence 4 94.92 High High
Schizophrenia 5 94.16 High High
Ganglion Cysts 12 91.72 High High
Injury 4 75.36 Quite High
Nociception 5 75.00 Quite High
Pain 4 68.00 Quite High
Neuropathic Pain 2 62.92 Quite High
Nervous System Injury 1 26.64 Quite Low
Depression 7 5.00 Very Low Very Low Very Low
Cognitive Disorder 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Group II mGluR antagonist-produced impairments in the acquisition of amphetamine CPP may be mediated by effects on PKA.
Gene_expression (produced) of Group II mGluR associated with antagonist
1) Confidence 0.45 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501036 Disease Relevance 0 Pain Relevance 0.61
Cells expressing mGluR2 alone exhibited 57 ± 5% inhibition of calcium current in response to glutamate (n = 6), while those coexpressing Siah1a were inhibited 61 ± 2% (n = 6; figure 2).
Gene_expression (expressing) of mGluR2 associated with glutamate
2) Confidence 0.33 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0.15
Siah1a attenuated heterologously expressed group I mGluR-mediated calcium current inhibition, but was without effect on group II mGluR- or NE-mediated calcium current modulation via heterologously expressed mGluR2 or native a2 adrenergic receptors, respectively, indicating that the effect of Siah was specific for group I mGluRs.
Gene_expression (expressed) of mGluR2
3) Confidence 0.29 Published 2001 Journal BMC Neurosci Section Abstract Doc Link PMC58838 Disease Relevance 0.09 Pain Relevance 0.12
The aim of the present study was to investigate the effect of repeated intermittent MDMA administration upon gene-transcript expression of the glutamate transporters (EAAT1, EAAT2-1, EAAT2-2), the glutamate receptor subunits of AMPA (GluR1, GluR2, GluR3), the glutamate receptor subunits of NMDA (NR1, NR2A and NR2B), as well as metabotropic glutamate receptors (mGluR1, mGluR2, mGluR3, mGluR5) in six different brain regions.
Spec (investigate) Gene_expression (expression) of mGluR2 in brain associated with glutamate and glutamate receptor
4) Confidence 0.20 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2358913 Disease Relevance 0.19 Pain Relevance 0.46
An increased mGlu2/3 receptor expression was also observed in the cerebral cortex but not in the hippocampus or cerebellum of LAC-treated animals.
Gene_expression (expression) of mGlu2 in cerebral cortex associated with hippocampus and cerebral cortex
5) Confidence 0.20 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 11961116 Disease Relevance 0.41 Pain Relevance 0.99
In addition, RT-PCR also revealed the expression of M2R, which did not seem to contribute to the calcium changes since it was not prevented by the M2 receptor antagonist, gallamine.
Gene_expression (expression) of M2R associated with antagonist
6) Confidence 0.06 Published 2000 Journal J. Neurophysiol. Section Abstract Doc Link 11024086 Disease Relevance 0.20 Pain Relevance 0.25

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