INT91319

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Context Info
Confidence 0.63
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 3.86
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CD63) plasma membrane (CD63)
Anatomy Link Frequency
platelet 3
blood 1
basophils 1
CD63 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 6 100.00 Very High Very High Very High
Angina 24 97.68 Very High Very High Very High
Kinase C 35 97.42 Very High Very High Very High
cINOD 1 97.12 Very High Very High Very High
Inflammation 20 93.08 High High
cytokine 3 33.96 Quite Low
agonist 14 5.00 Very Low Very Low Very Low
Spinal cord 7 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 20 97.68 Very High Very High Very High
INFLAMMATION 19 96.40 Very High Very High Very High
Stress 5 91.36 High High
Stable Angina Pectoris 4 89.32 High High
Adverse Drug Reaction 1 88.64 High High
Coronary Stenosis 4 88.56 High High
Coronary Artery Disease 10 87.56 High High
Apoptosis 6 82.92 Quite High
Myocardial Infarction 2 79.96 Quite High
Disease 15 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upregulation of CD63 or CD203c alone or in combination is not sensitive in the diagnosis of nonsteroidal anti-inflammatory drug intolerance.
Positive_regulation (Upregulation) of CD63 associated with aspirin, inflammation and cinod
1) Confidence 0.63 Published 2009 Journal Int. Arch. Allergy Immunol. Section Title Doc Link 19494523 Disease Relevance 0.19 Pain Relevance 0.38
Previous evidence has reported that CD203c and CD63 upregulation in response to calcium signal by A23187 showed different kinetics [28], an evidence that probably suggests different pathways of calcium involvement in the expression of the two markers [46].
Positive_regulation (upregulation) of CD63
2) Confidence 0.58 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0.19
In our assay system the flavonol proved insensitive to target protein kinase C (PKC), as resulted from the use of PMA as basophil stimulant, thus confirming previous reports [19]: quercetin was unable to inhibit CD63 and CD203c membrane up-regulation in basophils stimulated with phorbol esters and no dissociation between the two markers investigated was actually observed by using PMA [45].
Positive_regulation (up-regulation) of CD63 in basophils associated with kinase c
3) Confidence 0.39 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0.28
Patients exhibited higher PMPs, increased platelet %CD62P, %CD63 and soluble P selectin (all P < 0.01) and hs-CRP (P = 0.0167) than healthy controls.
Positive_regulation (increased) of CD63 in platelet
4) Confidence 0.26 Published 2005 Journal Platelets Section Abstract Doc Link 16194867 Disease Relevance 0.95 Pain Relevance 0.20
These mutations caused aberrant CD63 accumulation within the cytosol (p.T104N: Figure 6 I–J; p.I29V & p.Q206H: data not shown).
Positive_regulation (accumulation) of CD63
5) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.08 Pain Relevance 0
Activation-dependent epitope CD63 and glycoprotein IIb/IIIa on the platelet membrane were assayed.
Positive_regulation (dependent) of CD63 in platelet
6) Confidence 0.20 Published 2000 Journal Am. J. Cardiol. Section Abstract Doc Link 11024397 Disease Relevance 0.72 Pain Relevance 0.65
The percentage of platelets positive for the activation-dependent epitope CD63 was 5 times higher in patients with unstable than stable angina (14.6 +/- 5.6% vs 2.75 +/- 1.6%, p = 0.0026).
Positive_regulation (activation) of CD63 in platelets associated with angina
7) Confidence 0.17 Published 2000 Journal Am. J. Cardiol. Section Abstract Doc Link 11024397 Disease Relevance 0.95 Pain Relevance 0.86
Peripheral blood was analysed for PMPs, percent platelets positive for CD62P and CD63 (all flow cytometry), soluble P selectin and hsCRP (both immunoassay).
Spec (analysed) Positive_regulation (positive) of CD63 in blood
8) Confidence 0.12 Published 2005 Journal Platelets Section Abstract Doc Link 16194867 Disease Relevance 0.96 Pain Relevance 0.21

General Comments

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