INT9132

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Context Info
Confidence 0.59
First Reported 1981
Last Reported 2010
Negated 0
Speculated 7
Reported most in Abstract
Documents 279
Total Number 286
Disease Relevance 88.05
Pain Relevance 203.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
spinal 8
neurons 7
spinal cord 5
hippocampus 4
brain 2
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 4245 100.00 Very High Very High Very High
amygdala 948 100.00 Very High Very High Very High
Morphine 374 100.00 Very High Very High Very High
sodium channel 17 100.00 Very High Very High Very High
Spinal cord 883 99.92 Very High Very High Very High
nMDA receptor antagonist 325 99.92 Very High Very High Very High
narcan 55 99.92 Very High Very High Very High
nMDA receptor 539 99.90 Very High Very High Very High
diabetic neuropathy 125 99.88 Very High Very High Very High
dexamethasone 30 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 514 100.00 Very High Very High Very High
Diabetic Neuropathy 125 99.88 Very High Very High Very High
Cv General 4 Under Development 107 99.84 Very High Very High Very High
Middle Cerebral Artery Infarction 106 99.84 Very High Very High Very High
Targeted Disruption 78 99.84 Very High Very High Very High
Hyperalgesia 829 99.82 Very High Very High Very High
Pain 1010 99.80 Very High Very High Very High
Nervous System Injury 91 99.64 Very High Very High Very High
Hypersensitivity 41 99.48 Very High Very High Very High
Ganglion Cysts 718 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, spinal cord administration of GM1 ganglioside, an intracellular inhibitor of PKC translocation/activation, reverses both increased levels of membrane-bound PKC and pain-related behaviors.
Negative_regulation (inhibitor) of PKC in spinal cord associated with pain, kinase c and spinal cord
1) Confidence 0.59 Published 1992 Journal Brain Res. Section Abstract Doc Link 1393564 Disease Relevance 0.77 Pain Relevance 0.91
Bolus i.t. chelerythrine or GF109203X (GF), another PKC inhibitor, on d5, but not the inactive homologue of GF Bisindolymaleimide V, also blocked development of tolerance after 24 h.
Negative_regulation (inhibitor) of PKC associated with kinase c and tolerance
2) Confidence 0.59 Published 2000 Journal Pain Section Abstract Doc Link 10781912 Disease Relevance 0 Pain Relevance 1.65
Blocking the PKC activity prevents expression of the morphine tolerance.
Negative_regulation (Blocking) of PKC associated with kinase c, tolerance and morphine
3) Confidence 0.59 Published 2000 Journal Pain Section Abstract Doc Link 10781912 Disease Relevance 0 Pain Relevance 1.65
This study compared the effects of pharmacological inhibition of PKC with either GF 109203X or chelerythrine on persistent pain following noxious chemical stimulation with its effects on mechanical hyperalgesia, which develops in the hindpaw contralateral to an injury produced by noxious thermal stimulation.
Negative_regulation (inhibition) of PKC associated with pain, hyperalgesia, kinase c, lasting pain and injury
4) Confidence 0.59 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7751909 Disease Relevance 0.65 Pain Relevance 0.77
Bindolylmaleimide I (BIM), a specific inhibitor of PKC activity, abolished the effect of PMA.
Negative_regulation (inhibitor) of PKC associated with kinase c
5) Confidence 0.59 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11587715 Disease Relevance 0.37 Pain Relevance 0.97
Similarly, in vivo in 7-day-old rat pups, inhibition of PKC, but not PKC gamma, prevented thermal hyperalgesia precipitated by naloxone at 30 min post-morphine.
Negative_regulation (inhibition) of PKC associated with kinase c, thermal hyperalgesia, narcan and morphine
6) Confidence 0.58 Published 2004 Journal Pain Section Abstract Doc Link 15275778 Disease Relevance 0.61 Pain Relevance 1.74
Thus, when 5-HT release was diminished the uptake of D-fenfluramine inhibited PKC.
Negative_regulation (inhibited) of PKC associated with kinase c
7) Confidence 0.58 Published 2003 Journal Synapse Section Abstract Doc Link 14515339 Disease Relevance 0 Pain Relevance 0.89
The increased PKC activity is linked to the outward transport of dopamine, and when release is diminished, the inward transport of amphetamine inhibits PKC instead.
Negative_regulation (inhibits) of PKC associated with dopamine and kinase c
8) Confidence 0.58 Published 2003 Journal Synapse Section Abstract Doc Link 14515339 Disease Relevance 0 Pain Relevance 0.51
It was also attenuated by pretreatment with PCPA, resulting in a dose-dependent inhibition of PKC instead.
Negative_regulation (inhibition) of PKC associated with kinase c
9) Confidence 0.58 Published 2003 Journal Synapse Section Abstract Doc Link 14515339 Disease Relevance 0 Pain Relevance 0.92
Exposure of rat colon to pentobarbital produced as much as a 90% inhibition of calcium-dependent PKC activity, whereas calcium-independent activity was stimulated by as much as 35%.
Negative_regulation (inhibition) of PKC in colon associated with kinase c
10) Confidence 0.57 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539661 Disease Relevance 0 Pain Relevance 0.46
Because activation of protein kinase C (PKC) may occur following the activation of glutamate receptors, we determined whether pharmacological inhibition of PKC would attenuate morphine-induced c-Fos expression, and whether acute administration of morphine would induce translocation of PKC.
Spec (whether) Negative_regulation (inhibition) of PKC associated with kinase c, glutamate receptor and morphine
11) Confidence 0.57 Published 2004 Journal Brain Res. Bull. Section Abstract Doc Link 14709343 Disease Relevance 0 Pain Relevance 1.21
This sensitizing action of PKC activators on peptide release was significantly reduced by PKC down-regulation or by pretreating cultures with 10 nM staurosporine.
Negative_regulation (down-regulation) of PKC associated with kinase c
12) Confidence 0.57 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8667028 Disease Relevance 0 Pain Relevance 0.93
Down-regulation of PKC significantly attenuated the release of peptides evoked by either PDBu or bradykinin.
Negative_regulation (Down-regulation) of PKC associated with kinase c and bradykinin
13) Confidence 0.57 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8667028 Disease Relevance 0 Pain Relevance 0.86
Although use of the PKC inhibitor staurosporine failed to reverse lindane's inhibitory action, depletion of PKC activity through prolonged exposure to TPA partially reversed lindane's effect.
Negative_regulation (depletion) of PKC associated with kinase c
14) Confidence 0.57 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7532876 Disease Relevance 0 Pain Relevance 0.32
Pre-exposing slices to 1 microM bisindolylmaleimide I, an inhibitor of PKC activity, prevents the facilitation of peptide release induced by PDBu.
Negative_regulation (inhibitor) of PKC associated with kinase c
15) Confidence 0.57 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10327195 Disease Relevance 0.13 Pain Relevance 0.90
In summary, riluzole blocked the persistent sodium current fully, and the calcium one partly, plus it decreased glutamatergic transmission probably via inhibition of PKC that regulated presynaptic NMDA receptors having a facilitatory effect on glutamate release.
Negative_regulation (inhibition) of PKC associated with glutamate, kinase c and nmda receptor
16) Confidence 0.57 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18445055 Disease Relevance 0 Pain Relevance 0.87
Inhibition of PKC not only blocked thermal hyperalgesia, but also reversed the reduction of morphine's analgesic effect in PTX-rats.
Negative_regulation (Inhibition) of PKC associated with kinase c, analgesic, thermal hyperalgesia and morphine
17) Confidence 0.57 Published 2003 Journal Acta Anaesthesiol. Sin. Section Abstract Doc Link 14768516 Disease Relevance 0.78 Pain Relevance 1.93
In contrast, desensitization of protein kinase C (PKC) or inhibition of tyrosine kinase by herbimycin were ineffective.
Negative_regulation (desensitization) of PKC associated with kinase c
18) Confidence 0.57 Published 1998 Journal Neuroendocrinology Section Abstract Doc Link 9873202 Disease Relevance 0.09 Pain Relevance 0.53
Moreover, chelerythrine and GF 109203X diminished the stimulatory action of beta-endorphin on the uptake of radioactive glucose at a concentration sufficient to inhibit protein kinase C (PKC).
Negative_regulation (inhibit) of PKC associated with kinase c
19) Confidence 0.57 Published 2002 Journal Horm. Metab. Res. Section Abstract Doc Link 12439785 Disease Relevance 0.40 Pain Relevance 0.52
A nonselective inhibitor of several PKC isozymes and a selective PKCepsilon inhibitor antagonized this prolonged hyperalgesic response equally.
Negative_regulation (inhibitor) of PKC associated with hyperalgesia
20) Confidence 0.57 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10844037 Disease Relevance 0.93 Pain Relevance 0.92

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