INT91320
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
With both models, similar results were obtained: HO-1 was localized predominantly to infiltrating, monocytic, but only rarely to ramified microglial cells or astrocytes surrounding the inflammatory lesions. | |||||||||||||||
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During heme breakdown, HO-1 and HO-2 release CO, biliverdin, and Fe(2+). | |||||||||||||||
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During heme breakdown, HO-1 and HO-2 release CO, biliverdin, and Fe(2+). | |||||||||||||||
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Localization of HO-1 by immunohistochemistry | |||||||||||||||
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Expression and localization of HNE, Nrf2, and HO-1 were investigated by Western blotting, immunohistochemistry, real-time RT-PCR, and in situ hybridization histochemistry. | |||||||||||||||
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To understand the protective mechanism against mucosal injury and oxidative stress in the stomach, we investigated sequential expression and localization of a product of lipid peroxidation and a chemical mediator of the oxidative response array, 4-hydroxynonenal (HNE), transcriptional factor, NF-E2-related factor (Nrf2), and the inducible heme oxygenase (HO-1) in the injured stomach. | |||||||||||||||
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HO-1 acts to release antioxidant molecules such as bilirubin and ferritin, which can neutralize the ROS produced mainly by infiltrating inflammatory cells, resulting in less tissue damage. | |||||||||||||||
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Protein levels were visualized by incubation with the following antibodies: bcl-2, caspase-3, ICAM-1, HO-1, NF-? | |||||||||||||||
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In class 2 (CLU, HMOX1, IL10RB, IL1R1, IL1R2, SERPINB2, SOD2, TIMP1, TNFRSF1A), the abundance of the transcripts significantly decreased but did not return to control values (Fig 2, 3). | |||||||||||||||
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General Comments
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