INT91320

Context Info Confidence 0.81 First Reported 2000 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 8 Total Number 9 Disease Relevance 4.06 Pain Relevance 1.28

endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1) cytosol (Hmox1) signal transduction (Hmox1) cell death (Hmox1)

Anatomy Link Frequency astrocytes 1 stomach 1 Hmox1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Neuritis 2 97.72 Inflammation 90 95.36 ischemia 19 89.12 chemokine 3 88.12 cytokine 32 86.68 fibrosis 44 86.00 anesthesia 4 82.40 Thoracotomy 2 78.48 qutenza 4 77.36 cva 1 5.72

Disease Link Frequency Relevance Heat Ureteral Obstruction 45 99.72 Apoptosis 47 99.16 Stress 37 98.82 Injury 22 98.40 Neuritis 2 97.72 Multiple Sclerosis 3 97.16 INFLAMMATION 112 95.36 Convalescence 17 94.76 Adhesions 15 89.60 Cv Unclassified Under Development 16 89.12

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

With both models, similar results were obtained: HO-1 was localized predominantly to infiltrating, monocytic, but only rarely to ramified microglial cells or astrocytes surrounding the inflammatory lesions.

Localization (localized) of HO-1 in astrocytes associated with inflammation

1) Confidence 0.81 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 11024540 Disease Relevance 0.77 Pain Relevance 0.25

During heme breakdown, HO-1 and HO-2 release CO, biliverdin, and Fe(2+).

Localization (release) of HO-1

2) Confidence 0.77 Published 2003 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 12709584 Disease Relevance 0.31 Pain Relevance 0.24

During heme breakdown, HO-1 and HO-2 release CO, biliverdin, and Fe(2+).

Localization (release) of HO

3) Confidence 0.77 Published 2003 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 12709584 Disease Relevance 0.31 Pain Relevance 0.24

Localization of HO-1 by immunohistochemistry

Localization (Localization) of HO

4) Confidence 0.69 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 0 Pain Relevance 0

Expression and localization of HNE, Nrf2, and HO-1 were investigated by Western blotting, immunohistochemistry, real-time RT-PCR, and in situ hybridization histochemistry.

Spec (investigated) Localization (localization) of HO-1

5) Confidence 0.65 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18617559 Disease Relevance 0.24 Pain Relevance 0.08

To understand the protective mechanism against mucosal injury and oxidative stress in the stomach, we investigated sequential expression and localization of a product of lipid peroxidation and a chemical mediator of the oxidative response array, 4-hydroxynonenal (HNE), transcriptional factor, NF-E2-related factor (Nrf2), and the inducible heme oxygenase (HO-1) in the injured stomach.

Localization (localization) of HO-1 in stomach associated with stress and injury

6) Confidence 0.65 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18617559 Disease Relevance 0.27 Pain Relevance 0.07

HO-1 acts to release antioxidant molecules such as bilirubin and ferritin, which can neutralize the ROS produced mainly by infiltrating inflammatory cells, resulting in less tissue damage.

Localization (release) of HO-1 associated with inflammation

7) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001459 Disease Relevance 1.41 Pain Relevance 0.33

Protein levels were visualized by incubation with the following antibodies: bcl-2, caspase-3, ICAM-1, HO-1, NF-?

Localization (visualized) of HO-1

8) Confidence 0.16 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.12 Pain Relevance 0.08

In class 2 (CLU, HMOX1, IL10RB, IL1R1, IL1R2, SERPINB2, SOD2, TIMP1, TNFRSF1A), the abundance of the transcripts significantly decreased but did not return to control values (Fig 2, 3).

Localization (decreased) of HMOX1

9) Confidence 0.05 Published 2010 Journal Immun Ageing Section Body Doc Link PMC2933667 Disease Relevance 0.63 Pain Relevance 0

General Comments

This test has worked.