INT9133

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 37
Total Number 40
Disease Relevance 10.95
Pain Relevance 30.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
spinal cord 6
spinal 2
colon 2
lung 2
spinal cord dorsal horn 2
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 518 100.00 Very High Very High Very High
Spinal cord 77 100.00 Very High Very High Very High
Morphine 68 100.00 Very High Very High Very High
Thermal hyperalgesia 10 100.00 Very High Very High Very High
Spontaneous pain 3 100.00 Very High Very High Very High
withdrawal 113 99.96 Very High Very High Very High
substance P 21 99.96 Very High Very High Very High
narcan 12 99.96 Very High Very High Very High
intrathecal 59 99.84 Very High Very High Very High
Glutamate 28 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 96 100.00 Very High Very High Very High
Hyperalgesia 68 100.00 Very High Very High Very High
Nociception 25 100.00 Very High Very High Very High
Nervous System Injury 19 100.00 Very High Very High Very High
Apoptosis 153 99.92 Very High Very High Very High
INFLAMMATION 15 99.44 Very High Very High Very High
Adult Respiratory Distress Syndrome 78 99.38 Very High Very High Very High
Pressure And Volume Under Development 43 97.72 Very High Very High Very High
Poisoning 27 97.24 Very High Very High Very High
Heart Rate Under Development 66 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both the development of thermal hyperalgesia and the increase in PKC gamma immunoreactivity in CCI rats were prevented by once daily intrathecal administration with 10 nmol MK-801 for 7 days.
Negative_regulation (prevented) of Positive_regulation (increase) of PKC associated with nervous system injury, thermal hyperalgesia and intrathecal
1) Confidence 0.59 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 8592645 Disease Relevance 0.62 Pain Relevance 0.68
Both three-dimensional increases in spinal cord membrane-bound PKC and nociceptive behaviors (thermal hyperalgesia and spontaneous pain behaviors) in CCI rats were reliably reduced after three daily intrathecal treatments with 80 nmol GM1 ganglioside (a glycosphingolipid shown to prevent PKC translocation/activation), the first of which was given 1 h after sciatic nerve ligation.
Negative_regulation (reduced) of Positive_regulation (increases) of PKC in spinal cord associated with pain, nociception, spinal cord, kinase c, nervous system injury, thermal hyperalgesia, spontaneous pain, sciatic nerve and intrathecal
2) Confidence 0.59 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8410149 Disease Relevance 1.25 Pain Relevance 1.56
In addition, spinal cord administration of GM1 ganglioside, an intracellular inhibitor of PKC translocation/activation, reverses both increased levels of membrane-bound PKC and pain-related behaviors.
Negative_regulation (reverses) of Positive_regulation (increased) of PKC in spinal cord associated with pain, kinase c and spinal cord
3) Confidence 0.59 Published 1992 Journal Brain Res. Section Abstract Doc Link 1393564 Disease Relevance 0.78 Pain Relevance 0.92
Moreover, both the development of morphine tolerance and the increase in PKC gamma immunoreactivity were prevented by co-administration of morphine with 10 nmol MK-801 between Day 2 and Day 7 of the eight day treatment schedule.
Negative_regulation (prevented) of Positive_regulation (increase) of PKC gamma associated with kinase c, tolerance and morphine
4) Confidence 0.59 Published 1995 Journal Brain Res. Section Abstract Doc Link 7552251 Disease Relevance 0 Pain Relevance 2.23
Bolus chelerythrine on d5 after spinal morphine infusion blocked upon an increase in PKC activity, confirming that at the behaviorally active dose the drug had the intended biochemical effect upon spinal PKC activity.
Negative_regulation (blocked) of Positive_regulation (increase) of PKC in spinal associated with kinase c and morphine
5) Confidence 0.59 Published 2000 Journal Pain Section Abstract Doc Link 10781912 Disease Relevance 0 Pain Relevance 1.86
Concomitant administration of the opioid receptor antagonist, naloxone, blocked the PKC upregulation by chronic morphine.
Negative_regulation (blocked) of Positive_regulation (upregulation) of PKC associated with kinase c, antagonist, narcan, opioid receptor and morphine
6) Confidence 0.59 Published 1994 Journal Brain Res. Section Abstract Doc Link 7953672 Disease Relevance 0 Pain Relevance 2.00
Inhibition of PKC activation has no effect on pain-related synaptic plasticity
Negative_regulation (Inhibition) of Positive_regulation (activation) of PKC associated with pain
7) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.46 Pain Relevance 0.43
The D-fenfluramine-induced increase in PKC activity was completely prevented, however, by pretreatment with SERT inhibitors and partially with ketanserin.
Negative_regulation (prevented) of Positive_regulation (increase) of PKC associated with kinase c
8) Confidence 0.43 Published 2003 Journal Synapse Section Abstract Doc Link 14515339 Disease Relevance 0 Pain Relevance 0.89
Unlike D-fenfluramine, the D/L-fenfluramine-induced increase in PKC activity was partially resistant to PCPA pretreatment but was attenuated with bupropion, a dopamine transporter (DAT) inhibitor.
Negative_regulation (attenuated) of Positive_regulation (increase) of PKC associated with dopamine and kinase c
9) Confidence 0.43 Published 2003 Journal Synapse Section Abstract Doc Link 14515339 Disease Relevance 0 Pain Relevance 0.93
The 5-HT-mediated increase in PKC activity was attenuated by pretreatment with the 5-HT(2) antagonist ketanserin, but not with the SERT inhibitor fluoxetine.
Neg (not) Negative_regulation (attenuated) of Positive_regulation (increase) of PKC associated with kinase c, antagonist and fluoxetine
10) Confidence 0.43 Published 2003 Journal Synapse Section Abstract Doc Link 14515339 Disease Relevance 0 Pain Relevance 0.79
Consistent with this finding, a specific peptide inhibitor of calcium-independent PKC, but not an inhibitor of calcium-dependent PKC gamma, blocked withdrawal hyperresponsiveness of the sVRP.
Negative_regulation (blocked) of Positive_regulation (calcium-dependent) of PKC associated with kinase c and withdrawal
11) Confidence 0.43 Published 2004 Journal Pain Section Abstract Doc Link 15275778 Disease Relevance 0.61 Pain Relevance 1.64
The SERT inhibitor-induced increase in PKC was unaffected by pretreatment with PCPA but was inhibited by calcium.
Negative_regulation (inhibited) of Positive_regulation (increase) of PKC associated with kinase c
12) Confidence 0.42 Published 2003 Journal Synapse Section Abstract Doc Link 14515339 Disease Relevance 0 Pain Relevance 0.84
The SERT inhibitor-induced increase in PKC was unaffected by pretreatment with PCPA but was inhibited by calcium.
Negative_regulation (inhibitor-induced) of Positive_regulation (increase) of PKC associated with kinase c
13) Confidence 0.42 Published 2003 Journal Synapse Section Abstract Doc Link 14515339 Disease Relevance 0 Pain Relevance 0.84
Exposure of rat colon to pentobarbital produced as much as a 90% inhibition of calcium-dependent PKC activity, whereas calcium-independent activity was stimulated by as much as 35%.
Negative_regulation (inhibition) of Positive_regulation (dependent) of PKC in colon associated with kinase c
14) Confidence 0.42 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539661 Disease Relevance 0 Pain Relevance 0.46
Known activators of PKC, 12-O-tetradecanoylphorbol 13-acetate (TPA) and 1,2-dioctanoyl-sn-glycerol, abolished gap junctional communication at nanomolar concentrations.
Negative_regulation (abolished) of Positive_regulation (activators) of PKC associated with kinase c
15) Confidence 0.42 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7532876 Disease Relevance 0 Pain Relevance 0.32
Our prior study using microdialysis was able prevent the effects of activation of PKC with NPC15437 [10].
Negative_regulation (prevent) of Positive_regulation (activation) of PKC associated with kinase c
16) Confidence 0.41 Published 2006 Journal Mol Pain Section Body Doc Link PMC1482680 Disease Relevance 0.29 Pain Relevance 1.07
The Janus tyrosine kinase inhibitor AG490, the selective protein kinase C (PKC) inhibitor, bisindolylmaleimide 1 (BIM1), as well as rottlerin, a selective blocker of the PKCdelta isoform, but not the cyclooxygenase inhibitor indomethacin, effectively reduced the effect.
Negative_regulation (inhibitor) of Positive_regulation (selective) of PKC associated with kinase c
17) Confidence 0.41 Published 2005 Journal Brain Section Abstract Doc Link 15817518 Disease Relevance 0.24 Pain Relevance 0.33
The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate blunted VR1 desensitization, and this effect was reversible in the presence of the PKC inhibitor bisindolylmaleimide I.
Negative_regulation (reversible) of Positive_regulation (presence) of PKC associated with kinase c
18) Confidence 0.41 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15513920 Disease Relevance 1.85 Pain Relevance 1.32
Western blot analysis revealed that myricitrin treatment fully prevented the protein kinase C (PKC) alpha and PKCepsilon activation by PMA in mice hind paws.
Negative_regulation (prevented) of Positive_regulation (activation) of PKC associated with kinase c
19) Confidence 0.41 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16260583 Disease Relevance 0.36 Pain Relevance 1.12
Inhibition of mitogen-activated protein kinase (10 microM U0126) or protein kinase C (PKC; bisindoylmaleimide, 5 microM) activation did not inhibit A1254-induced CREB phosphorylation.
Negative_regulation (Inhibition) of Positive_regulation (activation) of PKC associated with kinase c
20) Confidence 0.41 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421622 Disease Relevance 0 Pain Relevance 0.21

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