INT91333

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Context Info
Confidence 0.65
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 10.96
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL11) extracellular space (CXCL11) extracellular region (CXCL11)
cell-cell signaling (CXCL11)
Anatomy Link Frequency
synovial fluids 2
sciatic nerves 2
macrophage 1
blood 1
liver 1
CXCL11 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 104 100.00 Very High Very High Very High
rheumatoid arthritis 93 99.20 Very High Very High Very High
Arthritis 38 98.70 Very High Very High Very High
Inflammation 106 98.52 Very High Very High Very High
agonist 44 98.24 Very High Very High Very High
spinal inflammation 2 98.24 Very High Very High Very High
Multiple sclerosis 72 96.92 Very High Very High Very High
Central nervous system 49 96.36 Very High Very High Very High
Sciatic nerve 2 92.48 High High
Peripheral nervous system 6 91.52 High High
Disease Link Frequency Relevance Heat
Hypersensitivity 12 99.68 Very High Very High Very High
Viral Meningitis 6 99.36 Very High Very High Very High
Rheumatoid Arthritis 94 99.20 Very High Very High Very High
Contact Dermatitis 28 99.14 Very High Very High Very High
Sarcoidosis 81 99.08 Very High Very High Very High
Hepatitis C Virus Infection 15 99.00 Very High Very High Very High
Seronegative Spondarthritis 10 98.70 Very High Very High Very High
INFLAMMATION 117 98.52 Very High Very High Very High
Low Back Pain 2 98.24 Very High Very High Very High
Spondylarthropathies 2 97.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among these were MCP-1 (CCL2), MIG (CXCL9), IP-10 (CCL10), and I-TAC (CXCL11).
Gene_expression (these) of and I-TAC
1) Confidence 0.65 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.90 Pain Relevance 0.12
In synovial fluids of patients with spondylarthropathies (ie ankylosing spondylitis or psoriatic arthritis) or rheumatoid arthritis, significantly enhanced CXCL9, but not CXCL11 levels, were detected compared to concentrations in synovial fluids of patients with metabolic crystal-induced arthritis.
Gene_expression (detected) of CXCL11 in synovial fluids associated with seronegative spondarthritis, spinal inflammation, rheumatoid arthritis, spondylarthropathies and arthritis
2) Confidence 0.59 Published 2006 Journal Lab. Invest. Section Abstract Doc Link 16847431 Disease Relevance 0.70 Pain Relevance 0.54
In synovial fluids of patients with spondylarthropathies (ie ankylosing spondylitis or psoriatic arthritis) or rheumatoid arthritis, significantly enhanced CXCL9, but not CXCL11 levels, were detected compared to concentrations in synovial fluids of patients with metabolic crystal-induced arthritis.
Gene_expression (levels) of CXCL11 in synovial fluids associated with seronegative spondarthritis, spinal inflammation, rheumatoid arthritis, spondylarthropathies and arthritis
3) Confidence 0.59 Published 2006 Journal Lab. Invest. Section Abstract Doc Link 16847431 Disease Relevance 0.70 Pain Relevance 0.54
Elevated I-TAC mRNA and protein has also been found in the liver of chronic Hepatitis C patients [36].
Gene_expression (found) of I-TAC in liver associated with hepatitis c virus infection
4) Confidence 0.58 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.26 Pain Relevance 0.23
Increased expression of IP-10 and I-TAC in the peripheral blood of ten patients at the early onset of fever was confirmed by ELISA.
Gene_expression (expression) of I-TAC in blood associated with fever
5) Confidence 0.58 Published 2007 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2100376 Disease Relevance 1.30 Pain Relevance 0.05
troglitazone and pioglitazone, reduce the expression of MCP1 [33], IP-10

(CXCL3), MIG, I-TAC, MIP1?

Gene_expression (expression) of I-TAC
6) Confidence 0.58 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 1.68 Pain Relevance 0.90
B activation, and IP-10 and I-TAC production, do not have a direct effect on viral replication and are, rather, simply part of the immune response to infection.
Gene_expression (production) of I-TAC associated with infection
7) Confidence 0.58 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.12 Pain Relevance 0.07
In contrast to our negative findings regarding macrophage polarization, previous studies have demonstrated higher expression of the M1 markers CXCL10 [6], CXCL11 [7] and CXCL16 [8] in sarcoidosis patients compared to healthy subjects.
Gene_expression (expression) of CXCL11 in macrophage associated with sarcoidosis
8) Confidence 0.40 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.36 Pain Relevance 0.11
Using real-time PCR, the relative gene expression of IL-10, IL-12p35, IL-12p40, IL-23p19, CCR2, CCR7, iNOS, CXCL10, CXCL11, CXCL16, CCL18, CCL20, CD80, and CD86, and innate immune receptors TLR2, TLR4, and TLR9, was quantified in sorted AMs, and for selected genes in total BAL cells, while IL-17A was quantified in T cells.


Gene_expression (expression) of CXCL11 in T cells
9) Confidence 0.36 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2939603 Disease Relevance 0.73 Pain Relevance 0.04
Flier J et al have demonstrated differences in chemokine expression between ACD and ICD reactions being CXCL9, CXCL10 and CXCL11 only detected in the allergic patch test lesions [42].
Gene_expression (detected) of CXCL11 associated with chemokine, hypersensitivity and contact dermatitis
10) Confidence 0.27 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.77 Pain Relevance 0.36
In the present study we report the expression pattern of the chemokines interferon-gamma-inducible protein (IP)-10, monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and regulated upon activation normal T cell expressed and secreted (RANTES) in sciatic nerves from animals with myelin-induced experimental autoimmune neuritis, using a semiquantitative reverse transcriptase-PCR dot-blot hybridization assay.
Gene_expression (expression) of interferon-gamma-inducible protein in sciatic nerves associated with chemokine, inflammation, experimental autoimmune neuritis, sciatic nerve and neuritis
11) Confidence 0.06 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 11024541 Disease Relevance 0.71 Pain Relevance 0.58
In the present study we report the expression pattern of the chemokines interferon-gamma-inducible protein (IP)-10, monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and regulated upon activation normal T cell expressed and secreted (RANTES) in sciatic nerves from animals with myelin-induced experimental autoimmune neuritis, using a semiquantitative reverse transcriptase-PCR dot-blot hybridization assay.
Gene_expression (expression) of interferon-gamma-inducible protein in sciatic nerves associated with chemokine, inflammation, experimental autoimmune neuritis, sciatic nerve and neuritis
12) Confidence 0.05 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 11024541 Disease Relevance 0.71 Pain Relevance 0.58

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