INT91337

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 29
Total Number 29
Disease Relevance 16.23
Pain Relevance 8.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL4) extracellular space (CCL4) extracellular region (CCL4)
cell adhesion (CCL4) cell-cell signaling (CCL4)
Anatomy Link Frequency
macrophage 3
brain 3
sciatic nerves 3
plasma 2
microglia 2
CCL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 403 100.00 Very High Very High Very High
cytokine 267 100.00 Very High Very High Very High
chemokine 257 100.00 Very High Very High Very High
Sciatic nerve 4 99.84 Very High Very High Very High
Paracetamol 6 99.80 Very High Very High Very High
Infliximab 109 99.44 Very High Very High Very High
antagonist 74 96.72 Very High Very High Very High
Neuritis 15 93.88 High High
rheumatoid arthritis 157 92.08 High High
Peripheral nervous system 10 91.52 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 483 100.00 Very High Very High Very High
Critical Illness 111 99.84 Very High Very High Very High
Infection 118 99.32 Very High Very High Very High
Disease 272 99.14 Very High Very High Very High
Stress 331 98.56 Very High Very High Very High
Adhesions 25 98.16 Very High Very High Very High
Influenza Virus Infection 46 96.56 Very High Very High Very High
Necrosis 51 95.40 Very High Very High Very High
Cancer 32 95.04 Very High Very High Very High
Experimental Autoimmune Neuritis 13 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study we report the expression pattern of the chemokines interferon-gamma-inducible protein (IP)-10, monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and regulated upon activation normal T cell expressed and secreted (RANTES) in sciatic nerves from animals with myelin-induced experimental autoimmune neuritis, using a semiquantitative reverse transcriptase-PCR dot-blot hybridization assay.
Gene_expression (expression) of MIP-1beta in sciatic nerves associated with chemokine, inflammation, experimental autoimmune neuritis, sciatic nerve and neuritis
1) Confidence 0.75 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 11024541 Disease Relevance 0.75 Pain Relevance 0.59
Our previous studies showed that interaction of Abeta1-40 or fibrilar Abeta1-42 caused activation of nuclear transcription factor, early growth response-1 (Egr-1), which resulted in increased expression of cytokines (TNF-alpha and IL-1beta) and chemokines (MIP-1beta, MCP-1 and IL-8) in monocytes.
Gene_expression (expression) of MIP-1beta in monocytes associated with chemokine and cytokine
2) Confidence 0.75 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15569263 Disease Relevance 0.86 Pain Relevance 0.43
Furthermore, the expression levels of Ang, brain-derived neurotrophic factor (BDNF), FGF-4, FGF-9, IGFBP-2, IL-8, MIP-1beta, OPG, pulmonary and activation-regulated protein (PARC), TGF-beta2, TIMP-2 and VEGF were significantly associated with the presence of JE; among these, nine cytokines (Ang, BDNF, FGF-4, FGF-9, IGFBP-2, MIP-1beta, PARC, TGF-beta2 and TIMP-2) were hitherto not described in TMD.
Gene_expression (expression) of MIP-1beta in brain
3) Confidence 0.75 Published 2006 Journal Dentomaxillofac Radiol Section Body Doc Link 17082335 Disease Relevance 0.13 Pain Relevance 0
Curcumin abrogated Abeta1-40-induced expression of cytokines (TNF-alpha and IL-1beta) and chemokines (MIP-1beta, MCP-1 and IL-8) in both peripheral blood monocytes and THP-1 cells.
Gene_expression (expression) of MIP-1beta in THP-1 associated with chemokine and cytokine
4) Confidence 0.75 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15569263 Disease Relevance 0.72 Pain Relevance 0.40
In the present study we report the expression pattern of the chemokines interferon-gamma-inducible protein (IP)-10, monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and regulated upon activation normal T cell expressed and secreted (RANTES) in sciatic nerves from animals with myelin-induced experimental autoimmune neuritis, using a semiquantitative reverse transcriptase-PCR dot-blot hybridization assay.
Gene_expression (expression) of MIP-1beta in sciatic nerves associated with chemokine, inflammation, experimental autoimmune neuritis, sciatic nerve and neuritis
5) Confidence 0.65 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 11024541 Disease Relevance 0.75 Pain Relevance 0.59
Gene-specific primers for the human genes CD74, V-FOS, NFKBIA, PTGS2, SCYA3L1, SCYA4, and the Arabidopsis gene RCA were designed with a 60°C melting temperature and a length of 19 to 25 bp for PCR products with a length of 90 to 130 bp, using ABI Primer Express 1.5 software (Applied Biosystems, Foster City, CA, USA).
Gene_expression (designed) of SCYA4
6) Confidence 0.65 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779452 Disease Relevance 0.07 Pain Relevance 0.03
However, increased IP-10 and MIP-1beta production in sciatic nerves were seen in CCR5(-/-) mice.
Gene_expression (production) of MIP-1beta in sciatic nerves associated with sciatic nerve
7) Confidence 0.65 Published 2004 Journal Neurobiol. Dis. Section Abstract Doc Link 15262275 Disease Relevance 1.11 Pain Relevance 1.17
Furthermore, the expression levels of Ang, brain-derived neurotrophic factor (BDNF), FGF-4, FGF-9, IGFBP-2, IL-8, MIP-1beta, OPG, pulmonary and activation-regulated protein (PARC), TGF-beta2, TIMP-2 and VEGF were significantly associated with the presence of JE; among these, nine cytokines (Ang, BDNF, FGF-4, FGF-9, IGFBP-2, MIP-1beta, PARC, TGF-beta2 and TIMP-2) were hitherto not described in TMD.
Gene_expression (levels) of MIP-1beta in brain
8) Confidence 0.58 Published 2006 Journal Dentomaxillofac Radiol Section Body Doc Link 17082335 Disease Relevance 0.13 Pain Relevance 0
The presence of IFN-gamma, IL-6, MCP-1, or MIP-1beta performed as well as magnetic resonance imaging in the prediction of intraoperative findings.
Gene_expression (presence) of MIP-1beta
9) Confidence 0.58 Published 2009 Journal J Bone Joint Surg Am Section Body Doc Link 19797564 Disease Relevance 0 Pain Relevance 0
However, serum levels of IL-6, CCL2 monocyte chemoattractant protein-1 (MCP-1), CCL3 [macrophage inflammatory protein-1alpha (MIP-1alpha)] and CCL4 (MIP-1beta) were markedly elevated.
Gene_expression (levels) of MIP-1beta in macrophage associated with inflammation
10) Confidence 0.58 Published 2009 Journal International journal of laboratory hematology Section Abstract Doc Link 18177436 Disease Relevance 0.77 Pain Relevance 0.17
Furthermore, the expression levels of Ang, brain-derived neurotrophic factor (BDNF), FGF-4, FGF-9, IGFBP-2, IL-8, MIP-1beta, OPG, pulmonary and activation-regulated protein (PARC), TGF-beta2, TIMP-2 and VEGF were significantly associated with the presence of JE; among these, nine cytokines (Ang, BDNF, FGF-4, FGF-9, IGFBP-2, MIP-1beta, PARC, TGF-beta2 and TIMP-2) were hitherto not described in TMD.
Gene_expression (expression) of MIP-1beta in brain
11) Confidence 0.58 Published 2006 Journal Dentomaxillofac Radiol Section Body Doc Link 17082335 Disease Relevance 0.13 Pain Relevance 0
However, serum levels of IL-6, CCL2 monocyte chemoattractant protein-1 (MCP-1), CCL3 [macrophage inflammatory protein-1alpha (MIP-1alpha)] and CCL4 (MIP-1beta) were markedly elevated.
Gene_expression (levels) of CCL4 in macrophage associated with inflammation
12) Confidence 0.55 Published 2009 Journal International journal of laboratory hematology Section Abstract Doc Link 18177436 Disease Relevance 0.77 Pain Relevance 0.17
The disease severity correlated with increased plasma levels of IL1RA, IL2, IL6, CCL3, CCL4 and IL10.
Gene_expression (levels) of CCL4 in plasma associated with disease
13) Confidence 0.51 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2948498 Disease Relevance 0.59 Pain Relevance 0.07
/CCL4 as well as IL-17 and IL-22) were detected.
Gene_expression (detected) of CCL4
14) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945042 Disease Relevance 0.27 Pain Relevance 0.10
The disease severity correlated with significant increase in IL1RA, IL2, IL6, CCL3, CCL4 and IL10 levels in critically ill patients.


Gene_expression (levels) of CCL4 associated with critical illness and disease
15) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.89 Pain Relevance 0.09
We identified higher plasma levels of IL1RA, IL2, IL6, CCL3, CCL4 and IL10 as markers of severity.
Gene_expression (levels) of CCL4 in plasma
16) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 1.02 Pain Relevance 0.23
Curcumin abrogated Abeta1-40-induced expression of cytokines (TNF-alpha and IL-1beta) and chemokines (MIP-1beta, MCP-1 and IL-8) in both peripheral blood monocytes and THP-1 cells.
Gene_expression (expression) of MIP-1beta in monocytes associated with chemokine and cytokine
17) Confidence 0.26 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15569263 Disease Relevance 0.72 Pain Relevance 0.40
Previous antimetabolite therapy should not prevent infliximab therapy since in ACT-1 and ACT-2 such patients were clearly responding.
Gene_expression (responding) of ACT-2 associated with infliximab
18) Confidence 0.24 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012439 Disease Relevance 0.40 Pain Relevance 0.32
, and RANTES (regulated on activation, normal T-cell expressed and secreted), which have been giving standard nomenclature CCL3, CCL4, and CCL5, respectively; CCR5 is expressed on immune cells, including effector and memory T-cells, natural killer cells, and antigen presenting cells (Blanpain et al 1999; Ruffing et al 1998).
Gene_expression (respectively) of CCL4 in natural killer cells
19) Confidence 0.22 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504054 Disease Relevance 0.23 Pain Relevance 0.42
This conclusion is supported, at least in part, by the results of Sukumaran and colleagues [52], who reported the upregulated expression of chemokine genes encoding CXCL1, CXCL2, CXCL3, CXCL8, CCL3, CCL4 and CCL20 after infection of PMN with Anaplasma phagocytophilum.
Gene_expression (expression) of CCL4 associated with chemokine and infection
20) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.59 Pain Relevance 0.50

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