INT91338

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Context Info
Confidence 0.48
First Reported 2000
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 26.86
Pain Relevance 5.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lep) extracellular space (Lep) extracellular region (Lep)
intracellular (Lep) lipid metabolic process (Lep)
Anatomy Link Frequency
body 4
fat 2
plasma 1
PVN 1
neuronal 1
Lep (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 1198 100.00 Very High Very High Very High
Pain 224 99.00 Very High Very High Very High
Neuropeptide 6 98.76 Very High Very High Very High
rheumatoid arthritis 47 96.84 Very High Very High Very High
Inflammation 290 93.60 High High
melanocortin 1 receptor 6 90.36 High High
medulla 2 89.04 High High
qutenza 2 86.16 High High
adenocard 2 85.72 High High
agonist 12 84.88 Quite High
Disease Link Frequency Relevance Heat
Obesity 1948 100.00 Very High Very High Very High
Osteoarthritis 1045 100.00 Very High Very High Very High
Neurological Disease 2 99.98 Very High Very High Very High
Disease 157 99.82 Very High Very High Very High
Metabolic Syndrome 21 99.52 Very High Very High Very High
Nicotine Addiction 50 99.40 Very High Very High Very High
Cognitive Disorder 29 99.36 Very High Very High Very High
Weight Loss 22 99.08 Very High Very High Very High
Pain 211 99.00 Very High Very High Very High
Targeted Disruption 124 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After controlling for interactions among these variables with a multivariate model, leptin remained significantly associated with percentage body fat and the knee osteoarthritis score (Table 3).
leptin Binding (associated) of in fat associated with knee osteoarthritis and osteoarthritis
1) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.57 Pain Relevance 0.24
Consistent with its pleiotropic role, leptin interacts with many signalling pathways including those involving NO [64].
leptin Binding (interacts) of
2) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.40 Pain Relevance 0.05
Leptin supplementation at
                   physiological levels (0.5 and 1.0 nM) ablated obesity-induced
                       O2? 
Leptin Binding (supplementation) of associated with obesity
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.71 Pain Relevance 0
Explants were treated independently or in combination with recombinant human leptin (1, 10, and 100 ng/ml; Bachem, Torrance, CA, USA), porcine IL-1?
leptin Binding (combination) of
4) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.07 Pain Relevance 0.15
The strong association between leptin and disease severity, coupled with the recent observation that obesity due to the impairment of leptin signaling does not cause osteoarthritis in mice [76], suggests that leptin itself may be a target for osteoarthritis in obese patients.
leptin Binding (target) of associated with obesity, disease and osteoarthritis
5) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 1.96 Pain Relevance 0.63
The strong association between leptin and disease severity, coupled with the recent observation that obesity due to the impairment of leptin signaling does not cause osteoarthritis in mice [76], suggests that leptin itself may be a target for osteoarthritis in obese patients.
leptin Binding (association) of associated with obesity, disease and osteoarthritis
6) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 1.95 Pain Relevance 0.62
Explants were treated independently or in combination with recombinant human leptin (1, 10, and 100 ng/ml; Bachem, Torrance, CA, USA), porcine IL-1?
leptin Binding (recombinant) of
7) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.07 Pain Relevance 0.15
Furthermore, several in vitro studies have suggested that high levels of leptin can induce IL-1 expression or can act synergistically with IL-1 to induce NOS2 expression [17,48].
leptin Binding (levels) of
8) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0.73 Pain Relevance 0.29
The ability of leptin to promote rapid changes in neuronal morphology may be critical for its role in both normal CNS function and in neurological diseases associated with leptin resistance and cognitive deficits.


leptin Binding (associated) of in neuronal associated with cognitive disorder and neurological disease
9) Confidence 0.35 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 1.45 Pain Relevance 0.06
In control hippocampal neurons (no leptin), Alexa-phalloidin staining was associated with the plasma membrane and actin rich structures such as filopodia and synapses.
leptin Binding (associated) of in plasma
10) Confidence 0.35 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0
Thus interactions between insulin, leptin, and glucocorticoids, and the neuropeptide responses they generate within the melanocortin system, allow complex metabolic responses to nutritional status but may also allow the development of metabolic pathologies.


leptin Binding (interactions) of associated with neuropeptide
11) Confidence 0.33 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.41 Pain Relevance 0.05
Synergistic interaction between CCK and leptin to regulate food intake.
leptin Binding (interaction) of
12) Confidence 0.33 Published 2000 Journal Regul. Pept. Section Title Doc Link 11024569 Disease Relevance 0.09 Pain Relevance 0.12
CCK co-injected with leptin potentiated Fos expression selectively in the area postrema, NTS and paraventricular nucleus of the hypothalamus (PVN), which points to the PVN as part of the afferent and efferent limbs of the circuitry involved in the synergistic interaction between leptin and CCK.
leptin Binding (interaction) of in PVN
13) Confidence 0.33 Published 2000 Journal Regul. Pept. Section Abstract Doc Link 11024569 Disease Relevance 0.07 Pain Relevance 0.12
Univariable and multivariable ordered logistic (ordinal) regressions with a partial proportional odds model were used to examine the associations between JSN and leptin or IL-6 before and after adjustment for age, sex, BMI, ever smoking, and disease status (diabetes, rheumatoid arthritis, cardiovascular disease, and asthma) in the whole sample, as well as in men or women separately.
leptin Binding (associations) of associated with asthma, nicotine addiction, cardiovascular disease, diabetes mellitus, obesity, rheumatoid arthritis and disease
14) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911879 Disease Relevance 0.87 Pain Relevance 0.05
In our results, it is not surprising that the association between OA and leptin decreased somewhat in magnitude after adjustment for IL-6, because leptin belongs structurally to the IL-6 family, and their serum levels were weakly related to each other in this sample.
leptin Binding (association) of associated with osteoarthritis
15) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911879 Disease Relevance 0.91 Pain Relevance 0.42
A significant positive association between IL-6 and leptin was found after adjustment for age, sex, BMI, smoking history, and disease status (r = 0.16; P = 0.032), although this association became nonsignificant when either sex group was analyzed.
leptin Binding (association) of associated with nicotine addiction, obesity and disease
16) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911879 Disease Relevance 1.38 Pain Relevance 0.14
BMI, WHR, total fat ratio, and trunk-fat ratio were each significantly associated with leptin (all P < 0.001) after adjustment for age, sex, height, ever smoked, diabetes, rheumatoid arthritis, cardiovascular disease, and asthma (data not shown), whereas only total fat and trunk-fat ratios were also associated with IL-6 (both P < 0.05).
leptin Binding (associated) of in fat associated with asthma, cardiovascular disease, diabetes mellitus, obesity and rheumatoid arthritis
17) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911879 Disease Relevance 0.65 Pain Relevance 0.05
The significant associations between osteoarthritis severity and serum leptin, adiponectin, and IL-1?
serum leptin Binding (associations) of associated with osteoarthritis
18) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 2.07 Pain Relevance 0.64
During that period the growth curves of both groups intercross with ob/ob mice becoming heavier than DBKO mutants.
ob Binding (intercross) of associated with targeted disruption and obesity
19) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 1.76 Pain Relevance 0
During that period the growth curves of both groups intercross with ob/ob mice becoming heavier than DBKO mutants.
ob Binding (intercross) of associated with targeted disruption and obesity
20) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 1.76 Pain Relevance 0

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