INT91340

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.82
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BGLAP) extracellular region (BGLAP) cell adhesion (BGLAP)
Golgi apparatus (BGLAP) structural molecule activity (BGLAP) cytoplasm (BGLAP)
Anatomy Link Frequency
osteoblasts 4
MG-63 4
BGLAP (Homo sapiens)
Pain Link Frequency Relevance Heat
MU agonist 9 100.00 Very High Very High Very High
opioid receptor 10 99.26 Very High Very High Very High
Morphine 7 91.76 High High
Enkephalin 5 90.72 High High
Pain 11 88.48 High High
Endogenous opioid 4 86.32 High High
narcan 48 81.28 Quite High
Opioid 2 79.76 Quite High
antagonist 2 79.20 Quite High
Inflammation 3 65.44 Quite High
Disease Link Frequency Relevance Heat
Cancer 66 99.88 Very High Very High Very High
Osteoporosis 18 99.54 Very High Very High Very High
Metastasis 26 98.36 Very High Very High Very High
Injury 6 96.04 Very High Very High Very High
Pain 11 88.48 High High
Stress 4 88.16 High High
Hypocalcemia 1 87.76 High High
Disease 6 86.72 High High
Osteoarthritis 2 85.44 High High
Fatigue 1 74.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In previous studies, opioid receptors were detected in human osteoblasts, and the effects of different opioid agonists on osteocalcin secretion were tested.
Regulation (effects) of Localization (secretion) of osteocalcin in osteoblasts associated with mu agonist and opioid receptor
1) Confidence 0.58 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1891106 Disease Relevance 0.69 Pain Relevance 0.88
We have therefore thought it of interest to study the presence of opioid receptors in the human osteoblast-like cell line MG-63, and to evaluate the effects of different opioid agonists on the secretion of alkaline phosphatase and osteocalcin by these cells.
Regulation (effects) of Localization (secretion) of osteocalcin in MG-63 associated with mu agonist, osteoporosis and opioid receptor
2) Confidence 0.40 Published 2000 Journal Neuroendocrinology Section Abstract Doc Link 11025413 Disease Relevance 0.63 Pain Relevance 0.79
Expression of opioid receptors in osteoblast-like MG-63 cells, and effects of different opioid agonists on alkaline phosphatase and osteocalcin secretion by these cells.
Regulation (effects) of Localization (secretion) of osteocalcin in MG-63 associated with mu agonist, osteoporosis and opioid receptor
3) Confidence 0.40 Published 2000 Journal Neuroendocrinology Section Title Doc Link 11025413 Disease Relevance 0.62 Pain Relevance 0.47
The effect of these drugs or of the addition of LTB(4) on alkaline phosphatase (AP) activity and osteocalcin release by OA and normal osteoblasts was determined.
Regulation (effect) of Localization (release) of osteocalcin in osteoblasts
4) Confidence 0.25 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12124864 Disease Relevance 0.09 Pain Relevance 0
For example, HA could alter tumor cell secretion of osteopontin and osteocalcin, two factors that regulate bone cell signaling and have a strong affinity for HA [34], [48]–[51].
Regulation (regulate) of Localization (secretion) of osteocalcin associated with cancer
5) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809751 Disease Relevance 0.80 Pain Relevance 0

General Comments

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