INT91341

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Context Info
Confidence 0.55
First Reported 2000
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 4.91
Pain Relevance 3.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BGLAP) extracellular region (BGLAP) cell adhesion (BGLAP)
Golgi apparatus (BGLAP) structural molecule activity (BGLAP) cytoplasm (BGLAP)
Anatomy Link Frequency
osteoblasts 2
BGLAP (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 33 99.98 Very High Very High Very High
Morphine 7 98.96 Very High Very High Very High
MU agonist 9 98.76 Very High Very High Very High
Enkephalin 5 98.44 Very High Very High Very High
opioid receptor 10 95.20 Very High Very High Very High
metalloproteinase 195 94.76 High High
agonist 2 94.20 High High
Osteoarthritis 390 91.96 High High
Endogenous opioid 4 88.56 High High
narcan 48 87.44 High High
Disease Link Frequency Relevance Heat
Osteoporosis 162 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 72 98.76 Very High Very High Very High
Injury 6 97.44 Very High Very High Very High
Hypercalcemia 8 97.32 Very High Very High Very High
Disease 34 94.68 High High
Hypocalcemia 1 93.92 High High
Osteoarthritis 429 91.96 High High
Pressure And Volume Under Development 144 86.60 High High
Stress 4 85.76 High High
Pain 23 85.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Osteocalcin synthesis in particular was significantly inhibited by high concentration of morphine and enkephalin [10].
Negative_regulation (inhibited) of Gene_expression (synthesis) of Osteocalcin associated with enkephalin and morphine
1) Confidence 0.55 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1891106 Disease Relevance 0.68 Pain Relevance 0.89
Since reduced osteocalcin production is a marker of decreased osteoblastic activity, this finding could be related to the pathogenesis of osteoporosis secondary to some diseases.
Negative_regulation (reduced) of Gene_expression (production) of osteocalcin associated with osteoporosis and disease
2) Confidence 0.52 Published 2000 Journal Neuroendocrinology Section Abstract Doc Link 11025413 Disease Relevance 0.60 Pain Relevance 0.28
A study of bone samples from anti-retroviral therapy-naïve HIV infected subjects compared with healthy controls showed only decreased levels of osteocalcin in individuals with lower CD4 counts.
Negative_regulation (decreased) of Gene_expression (levels) of osteocalcin associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.42 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074710 Disease Relevance 1.43 Pain Relevance 0.04
Osteocalcin synthesis was significantly inhibited by high concentrations of the mu agonists morphine and (D-Ala(2), N-MePhe(4),Gly(5)-ol)-enkephalin although no changes were seen with the delta agonist (D-Ala(2),D-leu(5))-enkephalin.
Negative_regulation (inhibited) of Gene_expression (synthesis) of Osteocalcin associated with mu agonist, agonist, enkephalin and morphine
4) Confidence 0.38 Published 2000 Journal Neuroendocrinology Section Abstract Doc Link 11025413 Disease Relevance 0.63 Pain Relevance 1.10
Secondly, corticosteroids inhibit osteoblastic activity and the synthesis of osteocalcin.
Negative_regulation (inhibit) of Gene_expression (synthesis) of osteocalcin associated with corticosteroid and osteoporosis
5) Confidence 0.17 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504079 Disease Relevance 0.58 Pain Relevance 0.22
We verified the inhibition of osteocalcin production with a commercially available rh-gal-3 (R&D Systems, Minneapolis, MN, USA).
Negative_regulation (inhibition) of Gene_expression (production) of osteocalcin
6) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0 Pain Relevance 0
Osteocalcin production was inhibited by around 40% and 85% at gal-3 concentrations of 1 and 10 ?
Negative_regulation (inhibited) of Gene_expression (production) of Osteocalcin
7) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0 Pain Relevance 0
The combination of gal-3 with either KT5720 or KT5823 also significantly inhibited osteocalcin production compared to their respective controls (p < 0.008 and p < 0.01, respectively), indicating that neither protein kinase A nor protein kinase G are involved in gal-3-inhibited osteocalcin production.
Negative_regulation (inhibited) of Gene_expression (production) of osteocalcin
8) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0 Pain Relevance 0
As previously described, in the absence of vitamin D3, osteocalcin expression was maintained at a minimal level, and gal-3 had no effect on osteocalcin expression (Figure 5b).
Negative_regulation (maintained) of Gene_expression (expression) of osteocalcin
9) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.13 Pain Relevance 0.06
g/ml gal-3 almost entirely inhibited osteocalcin production, we further examined the signalling cascades of gal-3 inhibition of vitamin D3-stimulated osteocalcin production with 5 ?
Negative_regulation (inhibited) of Gene_expression (production) of osteocalcin
10) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0 Pain Relevance 0
g/ml gal-3 almost entirely inhibited osteocalcin production, we further examined the signalling cascades of gal-3 inhibition of vitamin D3-stimulated osteocalcin production with 5 ?
Spec (examined) Negative_regulation (inhibition) of Gene_expression (production) of osteocalcin
11) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0 Pain Relevance 0
Taxifollin, an antioxidant flavonoid, also seemed to prevent gal-3 inhibition of osteocalcin production, but this inhibitor had the weakest effect.
Negative_regulation (inhibition) of Gene_expression (production) of osteocalcin
12) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0 Pain Relevance 0
In contrast, PD98059 prevented further inhibition of osteocalcin production by gal-3.
Negative_regulation (inhibition) of Gene_expression (production) of osteocalcin
13) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0 Pain Relevance 0
Vitamin D3-stimulated osteocalcin production tended to be inhibited by genistein (35%) and SB202190 (40%), indicating that tyrosine kinases and p38 mitogen-activated protein kinase may be slightly involved (Figure 6).
Negative_regulation (inhibited) of Gene_expression (production) of osteocalcin
14) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0 Pain Relevance 0
The combination of gal-3 with either KT5720 or KT5823 also significantly inhibited osteocalcin production compared to their respective controls (p < 0.008 and p < 0.01, respectively), indicating that neither protein kinase A nor protein kinase G are involved in gal-3-inhibited osteocalcin production.
Negative_regulation (inhibited) of Gene_expression (production) of osteocalcin
15) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0 Pain Relevance 0
Furthermore, using human osteoblasts, we showed that gal-3 inhibited osteocalcin production, which is encoded by the most specific and latest gene expressed by differentiated osteoblasts.
Negative_regulation (inhibited) of Gene_expression (production) of osteocalcin in osteoblasts
16) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.50 Pain Relevance 0.22
In contrast, in the presence of vitamin D3, gal-3 induced a dose-dependent inhibition of osteocalcin expression.
Negative_regulation (inhibition) of Gene_expression (expression) of osteocalcin
17) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.12 Pain Relevance 0.06
More particularly, production of osteocalcin, which is an osteoblastic marker [43], was strongly inhibited by gal-3.
Negative_regulation (inhibited) of Gene_expression (production) of osteocalcin associated with osteoporosis
18) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.24 Pain Relevance 0.14

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