INT91351

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 5.89
Pain Relevance 6.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx1) protein complex (P2rx1)
Anatomy Link Frequency
neurons 2
chromaffin cells 2
dorsal root ganglion 2
macrophages 1
embryonic stage 1
P2rx1 (Rattus norvegicus)
P2rx1 - K68A (1) P2rx1 - K309A (1)
Pain Link Frequency Relevance Heat
Spinal cord 26 100.00 Very High Very High Very High
nociceptor 12 100.00 Very High Very High Very High
qutenza 8 100.00 Very High Very High Very High
agonist 288 99.92 Very High Very High Very High
Nucleus accumbens 25 99.88 Very High Very High Very High
Central nervous system 58 99.44 Very High Very High Very High
Neuropeptide 7 99.24 Very High Very High Very High
Kinase C 291 98.94 Very High Very High Very High
antagonist 111 98.84 Very High Very High Very High
allodynia 21 98.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 66 99.60 Very High Very High Very High
Nervous System Injury 44 98.40 Very High Very High Very High
Neuropathic Pain 69 98.18 Very High Very High Very High
Pain 122 98.04 Very High Very High Very High
Injury 66 97.00 Very High Very High Very High
Nociception 39 95.88 Very High Very High Very High
INFLAMMATION 213 93.20 High High
Temporomandibular Joint Syndrome 42 92.68 High High
Inflammatory Pain 31 83.16 Quite High
Neurodegenerative Disease 95 80.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used whole-cell patch clamp recordings to study the expression of P2x receptor phenotypes, their distribution patterns, and their sensitivity to alphabetamATP and suramin in dorsal root ganglion (DRG) neurons acutely dissociated from adult rats.
Gene_expression (expression) of P2x in DRG associated with ganglion cysts and dorsal root ganglion
1) Confidence 0.75 Published 2000 Journal Exp Brain Res Section Abstract Doc Link 11026733 Disease Relevance 0.44 Pain Relevance 0.28
Thus, rat chromaffin cells have either been reported to lack P2X receptors [4] or to show a variable expression of P2X receptor subtypes (P2X1, P2X2, P2X5 and P2X7) [5,6]; there is also some evidence that these cells express P2X4 receptors in aged animals [7].
Gene_expression (express) of P2X in chromaffin cells
2) Confidence 0.75 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1906790 Disease Relevance 0 Pain Relevance 0.03
To elucidate the mechanisms underlying the blunted neuropathic allodynia in p2rx4-/- mice requires further investigations, but it may involve a lack of microglial P2X4Rs in the spinal cord, expression of which is markedly upregulated after nerve injury [7,22].
Gene_expression (expression) of P2X in nerve associated with nervous system injury, allodynia, neuropathic pain and spinal cord
3) Confidence 0.65 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704200 Disease Relevance 1.56 Pain Relevance 0.94
M) was ineffective as an agonist at P2X1 receptors, however, responses were evoked at 100 ?
Gene_expression (receptors) of P2X associated with agonist
4) Confidence 0.65 Published 2009 Journal Neuropharmacology Section Body Doc Link PMC2613953 Disease Relevance 0 Pain Relevance 0.05
A stock solution of P2X1 antibody (0.3 mg/ml) (Alomone, Israel) was prepared and 3 ?
Gene_expression (antibody) of P2X
5) Confidence 0.65 Published 2009 Journal Neuropharmacology Section Body Doc Link PMC2613953 Disease Relevance 0 Pain Relevance 0
Superfusion of the selective P2X1, P2X3 and P2X(2/3) receptor antagonist 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (6-638 microM) partially blocked the Vc central sensitization.
Gene_expression (Superfusion) of P2X1 associated with adenocard, central sensitization and antagonist
6) Confidence 0.60 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 15901761 Disease Relevance 0.23 Pain Relevance 0.65
It is widely accepted that P2X receptors, especially P2X3 and P2X2/3 selectively expressed in small DRG neurons, play an important role in pain transmission.
Gene_expression (expressed) of P2X in neurons associated with ganglion cysts and pain
7) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735677 Disease Relevance 0.61 Pain Relevance 0.25
In the presence of 2-azido ATP, HEK293 cells expressing P2X2–P2X4 were all UV irradiated for 3 min.
Gene_expression (expressing) of P2X
8) Confidence 0.58 Published 2009 Journal Neuropharmacology Section Body Doc Link PMC2613953 Disease Relevance 0 Pain Relevance 0
Their receptors (namely the ligand-gated P2X receptors, P2X1-7, and the metabotropic G protein-coupled P2Y receptors, P2Y1,2,4,6,11,12,13,14) are expressed not only by sensory neurons [48,49], but also by all the different glial cell populations involved in nociception, including SGCs [18,50], macrophages [51], astrocytes [52], and microglia [53].
Gene_expression (expressed) of P2X in macrophages associated with nociception
9) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.92 Pain Relevance 0.68
Co-expression of P2X1, and P2X3 in individual neurons was also demonstrated.
Gene_expression (Co-expression) of P2X1 in neurons
10) Confidence 0.41 Published 2000 Journal J. Chem. Neuroanat. Section Abstract Doc Link 11118807 Disease Relevance 0.08 Pain Relevance 0.12
We determined the co-expression of immunoreactivity (IR) for ATP-receptor subunits (P2X1, P2X2, and P2X3), neuropeptides, neurofilament (NF), and binding of the isolectin B(4) from Griffonia simplicifolia type one (GS-I-B(4)) in adult dorsal root ganglion neurons.
Spec (determined) Gene_expression (co-expression) of P2X1 in dorsal root ganglion associated with ganglion cysts, root ganglion neuron and neuropeptide
11) Confidence 0.41 Published 2000 Journal J. Chem. Neuroanat. Section Abstract Doc Link 11118807 Disease Relevance 0.09 Pain Relevance 0.14
Constitutive phosphorylation has been also demonstrated for the P2X1 receptor expressed in HEK293 cells [34].
Gene_expression (expressed) of P2X1
12) Confidence 0.41 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0.27
Reverse transcriptase polymerase chain reaction (RT-PCR) and Western blot analysis showed that, with the exception of the P2X6 receptor, these cells express all other P2X (i.e., P2X1–5 and P2X7) and P2Y receptors (i.e., P2Y1, P2Y2, P2Y4, P2Y6, P2Y12 and P2Y14) cloned from rodent tissues (P2Y11 was not investigated based on bioinformatics data, suggesting that this receptor is not present in rat and murine genomes).
Neg (exception) Gene_expression (express) of P2X1
13) Confidence 0.37 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 0.19 Pain Relevance 0
In particular, there are seven subunits of P2X receptors (P2X1–7), which are differently expressed by many cell types [4].
Gene_expression (expressed) of P2X1
14) Confidence 0.36 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.43 Pain Relevance 0.37
Distribution of P2X1, P2X2, and P2X3 receptor subunits in rat primary afferents: relation to population markers and specific cell types.
Gene_expression (Distribution) of P2X1 associated with qutenza
15) Confidence 0.35 Published 2000 Journal J. Chem. Neuroanat. Section Title Doc Link 11118807 Disease Relevance 0.09 Pain Relevance 0.43
Further evidence against a direct PKC-mediated P2X receptor phosphorylation comes from co-expression studies of P2X1 and G protein-coupled receptors.
Gene_expression (expression) of P2X1 associated with kinase c
16) Confidence 0.35 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0.34
with P2X1 receptors produced a 2.5-fold increase of the P2X1 receptor-mediated current that was blocked by the PKC inhibitor staurosporine and could be mimicked by PMA treatment of singly expressed P2X1 receptors.
Gene_expression (expressed) of P2X1 associated with kinase c
17) Confidence 0.35 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0.40
Arrows indicate migration positions of P2X1, P2X2 and P2X3 subunits.
Gene_expression (positions) of P2X1
18) Confidence 0.35 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0.27
P2X1, P2X4, and P2X7 receptors were expressed in microglia at rat embryonic stage (E16) [59].
Gene_expression (expressed) of P2X1 in embryonic stage
19) Confidence 0.34 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0 Pain Relevance 0.16
Effectively, human P2X1 and P2X7 receptors are co-expressed in several cell types such as lymphocytes or epithelial cells [39], and oATP was found to be ineffective in separating P2X1 receptor current from the P2X7 current.
Gene_expression (expressed) of P2X1 in lymphocytes
20) Confidence 0.32 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.47 Pain Relevance 0.43

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