INT91357

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Context Info
Confidence 0.61
First Reported 2000
Last Reported 2005
Negated 2
Speculated 5
Reported most in Abstract
Documents 5
Total Number 11
Disease Relevance 0
Pain Relevance 11.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dnm2) cytoskeleton (Dnm2) nucleus (Dnm2)
GTPase activity (Dnm2) protein complex (Dnm2) cytoplasm (Dnm2)
Anatomy Link Frequency
spinal cord 6
Dnm2 (Mus musculus)
Pain Link Frequency Relevance Heat
Immobilon 57 100.00 Very High Very High Very High
opioid receptor 47 100.00 Very High Very High Very High
mu opioid receptor 19 100.00 Very High Very High Very High
Opioid 12 100.00 Very High Very High Very High
Dynorphin 2 100.00 Very High Very High Very High
Morphine 26 99.84 Very High Very High Very High
Potency 2 99.80 Very High Very High Very High
agonist 14 99.64 Very High Very High Very High
Spinal cord 37 99.60 Very High Very High Very High
MU agonist 29 99.60 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Continuous opioid agonist treatment dose-dependently regulates mu-opioid receptors and dynamin-2 in mouse spinal cord.
Regulation (regulates) of dynamin-2 in spinal cord associated with mu agonist, mu opioid receptor, immobilon and spinal cord
1) Confidence 0.61 Published 2005 Journal Synapse Section Title Doc Link 15765525 Disease Relevance 0 Pain Relevance 0.92
Results indicate that etorphine induced dose-dependent regulation of muOR density, DYN-2 proteins, and mRNA abundance in mouse spinal cord.
Regulation (regulation) of DYN-2 in spinal cord associated with spinal cord and immobilon
2) Confidence 0.61 Published 2005 Journal Synapse Section Abstract Doc Link 15765525 Disease Relevance 0 Pain Relevance 0.91
Therefore, we examined etorphine and morphine effects on regulation of GRK-2 and DYN-2 in mouse spinal cord.
Spec (examined) Regulation (regulation) of DYN-2 in spinal cord associated with spinal cord, morphine and immobilon
3) Confidence 0.60 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435815 Disease Relevance 0 Pain Relevance 1.31
Morphine had no effect on either DYN-2 or GRK-2 protein or mRNA abundance.
Neg (no) Regulation (effect) of DYN-2 associated with morphine
4) Confidence 0.60 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435815 Disease Relevance 0 Pain Relevance 1.48
Opioid agonist and antagonist treatment differentially regulates immunoreactive mu-opioid receptors and dynamin-2 in vivo.
Regulation (regulates) of dynamin-2 associated with mu agonist, antagonist and mu opioid receptor
5) Confidence 0.46 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 15363980 Disease Relevance 0 Pain Relevance 1.36
Therefore, the present study examined the effect of various infusion doses of etorphine on muOR density, DYN-2 protein, and DYN-2 mRNA abundance in mouse spinal cord.
Spec (examined) Regulation (effect) of DYN-2 protein in spinal cord associated with spinal cord and immobilon
6) Confidence 0.45 Published 2005 Journal Synapse Section Abstract Doc Link 15765525 Disease Relevance 0 Pain Relevance 0.84
Therefore, this study examined muOR density, agonist potency, and the abundance and gene expression of GRK-2, DYN-2, and G(ialpha2) in mouse spinal cord after opioid antagonist treatment.
Spec (examined) Regulation (abundance) of DYN-2 in spinal cord associated with antagonist, agonist, opioid, spinal cord and potency
7) Confidence 0.42 Published 2003 Journal Synapse Section Abstract Doc Link 12872295 Disease Relevance 0 Pain Relevance 0.80
Delivery of the same daily dose of etorphine or naloxone using intermittent (every 24 h for 7 days) s.c. administration had no effect on immunoreactive mu-opioid receptor, [3H] DAMGO binding or dynamin-2 abundance.
Neg (no) Regulation (effect) of dynamin-2 associated with narcan, opioid receptor and immobilon
8) Confidence 0.30 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363980 Disease Relevance 0 Pain Relevance 1.12
These data indicate that mu-opioid receptor density, determined in radioligand binding assays, and immunoreactive dynamin-2 abundance are regulated by continuous, but not intermittent, opioid ligand treatment.
Regulation (regulated) of immunoreactive dynamin-2 associated with opioid receptor and opioid
9) Confidence 0.20 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363980 Disease Relevance 0 Pain Relevance 1.03
Therefore, the present study examined the effect of various infusion doses of etorphine on muOR density, DYN-2 protein, and DYN-2 mRNA abundance in mouse spinal cord.
Spec (examined) Regulation (effect) of DYN-2 mRNA in spinal cord associated with spinal cord and immobilon
10) Confidence 0.20 Published 2005 Journal Synapse Section Abstract Doc Link 15765525 Disease Relevance 0 Pain Relevance 0.85
OBJECTIVES: An unbiased place preference conditioning procedure was used to examine the influence of the non-opioid peptide, dynorphin A 2-17 (DYN 2-17), upon the conditioned and unconditioned effects of opiate withdrawal in the rat.
Spec (examine) Regulation (influence) of DYN 2-17 associated with dynorphin, opiate, withdrawal and opioid
11) Confidence 0.10 Published 2000 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 11026742 Disease Relevance 0 Pain Relevance 0.45

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