INT91368

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Context Info
Confidence 0.59
First Reported 2000
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 9.22
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (STAT3) DNA binding (STAT3) cytoplasm (STAT3)
signal transducer activity (STAT3) cell proliferation (STAT3) cytosol (STAT3)
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 40 91.08 High High
Inflammation 181 88.40 High High
cytokine 73 88.24 High High
addiction 2 85.36 High High
alcohol 17 80.28 Quite High
cINOD 13 79.80 Quite High
antagonist 7 65.40 Quite High
imagery 4 13.56 Low Low
Arthritis 22 5.00 Very Low Very Low Very Low
Inflammatory response 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibromyalgia 2 100.00 Very High Very High Very High
Cirrhosis 115 99.84 Very High Very High Very High
Hepatitis 67 99.20 Very High Very High Very High
Reprotox - General 1 2 98.84 Very High Very High Very High
Targeted Disruption 3 97.20 Very High Very High Very High
Chronic Hepatitis 62 96.72 Very High Very High Very High
Skin Cancer 23 95.64 Very High Very High Very High
Cancer 136 94.16 High High
Hepatitis C Virus Infection 14 91.56 High High
Disease 119 91.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, 3 days of sulindac treatment eliminated both phosphorylated and unphosphorylated Stat3 protein levels.
Negative_regulation (eliminated) of Phosphorylation (phosphorylated) of Stat3
1) Confidence 0.59 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861373 Disease Relevance 0.82 Pain Relevance 0.15
Western blot experiments showed that short-term treatment of cells with sulindac resulted in a large reduction of phosphorylated Stat3, without significantly affecting Stat3 protein levels.
Negative_regulation (reduction) of Phosphorylation (phosphorylated) of Stat3
2) Confidence 0.59 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861373 Disease Relevance 0.84 Pain Relevance 0.15
In contrast, 3 days of sulindac treatment eliminated both phosphorylated and unphosphorylated Stat3 protein levels.
Negative_regulation (eliminated) of Phosphorylation (unphosphorylated) of Stat3
3) Confidence 0.59 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861373 Disease Relevance 0.82 Pain Relevance 0.15
When we examined STAT3 under these conditions (Figure 3c), both RGD-stimulated recruitment to the insoluble fraction and phosphorylation of STAT3 were unaffected by DNSrc overexpression.
Neg (unaffected) Negative_regulation (unaffected) of Phosphorylation (phosphorylation) of STAT3
4) Confidence 0.40 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.04
By 1 wk RVPO, both STAT3 recruitment and phosphorylation were substantially reduced.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of STAT3
5) Confidence 0.40 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
Serine (Ser)-phosphorylated STAT3 was slightly decreased in CIRR.
Negative_regulation (decreased) of Phosphorylation (phosphorylated) of STAT3 associated with cirrhosis
6) Confidence 0.34 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.78 Pain Relevance 0
Lovastatin and/or celecoxib also inhibited caveolin-1-dependent cell survival signals mediated through Akt activation as well as its down-stream effectors such as phosphorylated ERK and STAT3 in HCT-116 cells.
Negative_regulation (inhibited) of Phosphorylation (phosphorylated) of STAT3
7) Confidence 0.34 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19787257 Disease Relevance 0.37 Pain Relevance 0.08
The levels of STAT3-Tyr phosphorylation were the lowest in AH and strongest in LDH.
Negative_regulation (levels) of Phosphorylation (phosphorylation) of STAT3 associated with hepatitis
8) Confidence 0.34 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.74 Pain Relevance 0.04
In contrast, AT1 inhibitors have been shown to inhibit the proliferation of prostate cancer cells stimulated with EGF or angiotensin II, through the suppression of MAPK or STAT3 phosphorylation [57].
Negative_regulation (suppression) of Phosphorylation (phosphorylation) of STAT3 associated with reprotox - general 1
9) Confidence 0.27 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 0.80 Pain Relevance 0.03
In NIH3T3 cells expressing a dominant negative G alpha i2, Stat3 phosphorylation by v-fms (oncogenic CSF1R) was inhibited [21].
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of Stat3 associated with fibromyalgia
10) Confidence 0.23 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC428583 Disease Relevance 1.00 Pain Relevance 0.34
In one study, Genistein, a nonspecific Tyr-kinase inhibitor, and AG490, a specific inhibitor of JAKs, markedly prevented the CuLDL-induced enhancement of STAT1 and STAT3 Tyr-phosphorylation and DNA-binding activity, suggesting that JAKs are the main kinases involved in STATs' activation by oxidized LDL [125].
Negative_regulation (prevented) of Phosphorylation (phosphorylation) of STAT3
11) Confidence 0.18 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.53 Pain Relevance 0.04
IL-6 itself may produce a delayed phosphorylation and activation of STAT3, and the JAK/STAT3 pathway is an indirect target of Ras and Rho GTPases [70].
Negative_regulation (delayed) of Phosphorylation (phosphorylation) of STAT3
12) Confidence 0.18 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.08 Pain Relevance 0
Studies on the mode of action revealed that CPDHC (1) affects the IL-6-dependent pathway by inhibiting the tyrosine phosphorylation of the STAT3 and STAT1 as well as the serine phosphorylation of the Stat3 transcription factor.
Negative_regulation (inhibiting) of Phosphorylation (phosphorylation) of STAT3
13) Confidence 0.10 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11027495 Disease Relevance 0.15 Pain Relevance 0.06
Studies on the mode of action revealed that CPDHC (1) affects the IL-6-dependent pathway by inhibiting the tyrosine phosphorylation of the STAT3 and STAT1 as well as the serine phosphorylation of the Stat3 transcription factor.
Negative_regulation (inhibiting) of Phosphorylation (phosphorylation) of Stat3
14) Confidence 0.10 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11027495 Disease Relevance 0.15 Pain Relevance 0.06
Studies on the mode of action revealed that CPDHC (1) affects the IL-6-dependent pathway by inhibiting the tyrosine phosphorylation of the STAT3 and STAT1 as well as the serine phosphorylation of the Stat3 transcription factor.
Negative_regulation (inhibiting) of Phosphorylation (phosphorylation) of STAT3
15) Confidence 0.10 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11027495 Disease Relevance 0.15 Pain Relevance 0.06

General Comments

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