INT91370

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.82
First Reported 2000
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 123
Total Number 125
Disease Relevance 49.25
Pain Relevance 8.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (STAT3) DNA binding (STAT3) cytoplasm (STAT3)
signal transducer activity (STAT3) cell proliferation (STAT3) cytosol (STAT3)
Anatomy Link Frequency
nucleus 14
myocardium 5
epithelial cells 5
blood 4
heart 4
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1229 99.68 Very High Very High Very High
Enkephalin 2 99.66 Very High Very High Very High
alcohol 112 99.48 Very High Very High Very High
opioid receptor 4 98.92 Very High Very High Very High
psoriasis 68 98.44 Very High Very High Very High
imagery 78 97.24 Very High Very High Very High
ischemia 34 97.16 Very High Very High Very High
Central nervous system 37 93.98 High High
Paracetamol 9 93.52 High High
Kinase C 10 92.64 High High
Disease Link Frequency Relevance Heat
Cancer 1247 100.00 Very High Very High Very High
Hypertrophy 367 100.00 Very High Very High Very High
Hepatitis C Virus Infection 81 99.92 Very High Very High Very High
Reprotox - General 1 7 99.80 Very High Very High Very High
Fibromyalgia 2 99.76 Very High Very High Very High
Hepatitis 368 99.60 Very High Very High Very High
Injury 375 99.40 Very High Very High Very High
Cirrhosis 633 99.36 Very High Very High Very High
Chronic Hepatitis 341 99.06 Very High Very High Very High
Hypoxia 162 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, 3 days of sulindac treatment eliminated both phosphorylated and unphosphorylated Stat3 protein levels.
Phosphorylation (unphosphorylated) of Stat3
1) Confidence 0.82 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861373 Disease Relevance 0.81 Pain Relevance 0.15
Western blot experiments showed that short-term treatment of cells with sulindac resulted in a large reduction of phosphorylated Stat3, without significantly affecting Stat3 protein levels.
Phosphorylation (phosphorylated) of Stat3
2) Confidence 0.82 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861373 Disease Relevance 0.84 Pain Relevance 0.15
In contrast, 3 days of sulindac treatment eliminated both phosphorylated and unphosphorylated Stat3 protein levels.
Phosphorylation (phosphorylated) of Stat3
3) Confidence 0.82 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861373 Disease Relevance 0.81 Pain Relevance 0.15
The sulfone metabolite of sulindac, which lacks cyclooxygenase-inhibitory activity, did not affect either Stat3 expression or Stat3 phosphorylation.
Phosphorylation (phosphorylation) of Stat3
4) Confidence 0.82 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861373 Disease Relevance 0.71 Pain Relevance 0.13
The cellular responses after warm ischemia were preceded by the molecular activation of nuclear factor kappa B, upregulation of granulocyte colony-stimulating factor and IL-6 mRNA and phosphorylation of the downstream signaling and transcription factor Stat3 [59].
Phosphorylation (phosphorylation) of Stat3 in granulocyte associated with ischemia
5) Confidence 0.80 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 1.51 Pain Relevance 0.23
Immunohistochemical analysis of muscle cross-sections was performed for the quantification of SCs (Pax7+ cells) as well as the expression of phosphorylated STAT3, IL-6, IL-6R?
Phosphorylation (phosphorylated) of STAT3 in muscle
6) Confidence 0.77 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2696599 Disease Relevance 0.13 Pain Relevance 0.04
The co-localization of p-STAT3 with Pax7 may be due to the phosphorylation of STAT3 protein within the SCs induced by the increase in IL-6 protein observed in the SCs at T4.
Phosphorylation (phosphorylation) of STAT3
7) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.12 Pain Relevance 0
In this study, there was no increase in whole muscle p-JAK2 or p-STAT3 protein at the time-points in which the muscle biopsies were obtained; however, the phosphorylation of STAT3 is very rapid and transient and it is possible that any increase in p-STAT3 detectable at the whole-muscle level occurred before T4 [41], [55].
Phosphorylation (phosphorylation) of STAT3 in muscle
8) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0 Pain Relevance 0
, JAK2 is phosphorylated and initiates the phosphorylation of STAT3.
Phosphorylation (phosphorylation) of STAT3
9) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0 Pain Relevance 0
Phosphorylated STAT3 was evident in SCs 4 h after lengthening contraction, and the downstream genes, cyclin D1 and SOCS3 were significantly elevated 24 hours after the intervention.


Phosphorylation (Phosphorylated) of STAT3
10) Confidence 0.76 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2696599 Disease Relevance 0 Pain Relevance 0.03
JAK2 and STAT3 phosphorylated and total protein was measured using western blotting techniques.
Phosphorylation (phosphorylated) of STAT3
11) Confidence 0.76 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2696599 Disease Relevance 0.15 Pain Relevance 0.05
STAT3 phosphorylation is regulated by SOCS3 as part of a negative feedback loop controlling the activation status of STAT3 proteins [58], [59].
Phosphorylation (phosphorylation) of STAT3
12) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.06 Pain Relevance 0.08
Therefore, our studies in PO feline myocardium cannot rule out JAK2's contribution to STAT3 phosphorylation in the early period of PO,41 where it might be subsequently inactivated by the expression of SOCS, and under these conditions, other NTKs might sustain STAT3 activation.
Phosphorylation (phosphorylation) of STAT3 in myocardium
13) Confidence 0.76 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.05
PO also caused increased levels of phosphorylated STAT3 in both cytoplasmic and nuclear fractions.
Phosphorylation (phosphorylated) of STAT3
14) Confidence 0.76 Published 2008 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC2443357 Disease Relevance 0.49 Pain Relevance 0
Since Tyr705 phosphorylation of STAT3 is indicative of its activation,6, 8, 18, 19 we wanted to determine whether phosphorylated STAT3 is present in the nucleus for transcriptional activation.
Spec (whether) Phosphorylation (phosphorylated) of STAT3 in nucleus
15) Confidence 0.76 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
When we examined STAT3 under these conditions (Figure 3c), both RGD-stimulated recruitment to the insoluble fraction and phosphorylation of STAT3 were unaffected by DNSrc overexpression.
Phosphorylation (phosphorylation) of STAT3
16) Confidence 0.76 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.04
Furthermore, increased tyrosine phosphorylation of STAT3 (P-STAT3) at Tyr705 (indicating activation) was detected in all three (soluble, CSK, and MSK) fractions of pressure-overloaded RV, when compared to normally loaded LV subfractions (right panel), although it was higher in Triton X-100 soluble and insoluble MSK fractions when compared to CSK fraction.
Phosphorylation (phosphorylation) of STAT3
17) Confidence 0.76 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.05 Pain Relevance 0
Since STAT3 phosphorylation was observed in both the nucleus and MSK of 48 h PO myocardium, even while JAK2 was inactive, these findings strongly suggest that BMX-mediated STAT3 activation not only contributes to cytoskeletal remodeling but also to the transcriptional activation in the nucleus.
Phosphorylation (phosphorylation) of STAT3 in myocardium
18) Confidence 0.76 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.16 Pain Relevance 0.03
However, our studies indicate that the tyrosine phosphorylation of STAT3 in 48 h PO myocardium does not appear to be required for the increased level of STAT3 in the nucleus, since the distribution of STAT3 or P-STAT3 between cytoplasm and nucleus was not significantly altered in 48 h PO myocardium.
Phosphorylation (phosphorylation) of STAT3 in nucleus
19) Confidence 0.76 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.19 Pain Relevance 0.08
Since both STAT3 and BMX exhibit similar redistribution and phosphorylation, these data and our in vivo observations showing a complex formation between BMX and STAT3 in PO myocardium strongly indicate that integrin-mediated BMX activation might serve as an upstream kinase for STAT3 activation in hypertrophying myocardium.
Phosphorylation (phosphorylation) of STAT3 in myocardium
20) Confidence 0.76 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.20 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox