INT91371

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Context Info
Confidence 0.59
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 34
Total Number 34
Disease Relevance 25.00
Pain Relevance 4.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (STAT3) DNA binding (STAT3) cytoplasm (STAT3)
signal transducer activity (STAT3) cell proliferation (STAT3) cytosol (STAT3)
Anatomy Link Frequency
enterocytes 1
IEC-6 1
immune cells 1
brain 1
salivary gland 1
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 267 100.00 Very High Very High Very High
qutenza 16 99.98 Very High Very High Very High
agonist 329 99.92 Very High Very High Very High
cINOD 29 99.66 Very High Very High Very High
rheumatoid arthritis 232 95.60 Very High Very High Very High
Leflunomide 45 95.20 Very High Very High Very High
cytokine 92 93.44 High High
Inflammatory response 27 91.88 High High
metalloproteinase 25 89.44 High High
antagonist 32 87.44 High High
Disease Link Frequency Relevance Heat
Cancer 1315 100.00 Very High Very High Very High
INFLAMMATION 303 100.00 Very High Very High Very High
Cirrhosis 178 99.84 Very High Very High Very High
Hepatitis 99 99.84 Very High Very High Very High
Solid Tumor 58 99.82 Very High Very High Very High
Hematologic Neoplasms 275 99.48 Very High Very High Very High
Skin Cancer 38 99.40 Very High Very High Very High
Metastasis 214 98.82 Very High Very High Very High
Myeloproliferative Disorder 45 98.42 Very High Very High Very High
Myelofibrosis 30 98.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot experiments showed that short-term treatment of cells with sulindac resulted in a large reduction of phosphorylated Stat3, without significantly affecting Stat3 protein levels.
Negative_regulation (reduction) of Stat3
1) Confidence 0.59 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861373 Disease Relevance 0.84 Pain Relevance 0.15
Our results suggest that down-modulation of Stat3 can be induced by sulindac treatment, thus possibly contributing to the antineoplastic effect of this drug.
Negative_regulation (down-modulation) of Stat3
2) Confidence 0.59 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861373 Disease Relevance 0.65 Pain Relevance 0.13
The nonsteroidal anti-inflammatory drug sulindac causes down-regulation of signal transducer and activator of transcription 3 in human oral squamous cell carcinoma cells.
Negative_regulation (down-regulation) of signal transducer and activator of transcription 3 associated with inflammation, cinod and skin cancer
3) Confidence 0.59 Published 2002 Journal Cancer Res. Section Title Doc Link 11861373 Disease Relevance 0.89 Pain Relevance 0.20
Antisense oligonucleotide treatment against peroxisome proliferator-activated receptor gamma did not attenuate the ability of sulindac to down-regulate Stat3.
Negative_regulation (down-regulate) of Stat3
4) Confidence 0.59 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861373 Disease Relevance 0.66 Pain Relevance 0.13
In contrast, 3 days of sulindac treatment eliminated both phosphorylated and unphosphorylated Stat3 protein levels.
Negative_regulation (eliminated) of Stat3
5) Confidence 0.59 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861373 Disease Relevance 0.82 Pain Relevance 0.15
Pervanadate reversed the capsaicin-induced down-regulation of STAT3, suggesting the involvement of a protein tyrosine phosphatase.
Negative_regulation (regulation) of STAT3
6) Confidence 0.55 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17505005 Disease Relevance 0.07 Pain Relevance 0
Sequential measurements of the same sample over time demonstrated a loss of p-STAT-3 in fresh specimens after 24 h (data not shown) and in frozen specimens, indicating samples should be processed and analyzed as soon as possible after being collected from the patient.
Negative_regulation (loss) of STAT-3
7) Confidence 0.50 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 1.22 Pain Relevance 0
Tyrosine (Tyr)-phosphorylated STAT3 was strongly reduced in AH and was increased in LDH.
Negative_regulation (reduced) of STAT3 associated with hepatitis
8) Confidence 0.47 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.65 Pain Relevance 0
Serine (Ser)-phosphorylated STAT3 was slightly decreased in CIRR.
Negative_regulation (decreased) of STAT3 associated with cirrhosis
9) Confidence 0.47 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.73 Pain Relevance 0
Inhibition of the oncogenic Stat3-survivin pathway in these cells can be achieved by selective targeting techniques or treatment with the NSAID sulindac and holds promise for the treatment of salivary gland cancer.


Negative_regulation (Inhibition) of Stat3 in salivary gland
10) Confidence 0.43 Published 2009 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 19272804 Disease Relevance 0 Pain Relevance 0
Furthermore, we selected this particular marker of immune suppression because IL-2 has been shown to regulate FoxP3 expression in human CD4+CD25+ Tregs [48] by inducing STAT-3 binding of the first intron of the FoxP3 gene [20] and because STAT-3 inhibitors have been shown to inhibit Tregs [26,36].
Negative_regulation (inhibitors) of STAT-3
11) Confidence 0.42 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.48 Pain Relevance 0.06
CONCLUSION: Overall, these results suggest that capsaicin is a novel blocker of the STAT3 activation pathway, with a potential role in the prevention and treatment of multiple myeloma and other cancers.


Negative_regulation (blocker) of STAT3
12) Confidence 0.40 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17505005 Disease Relevance 0 Pain Relevance 0
Furthermore, we have shown that p-STAT-3 blockade in immune cells restores immune responses [25] and inhibits Treg induction [26].
Negative_regulation (blockade) of STAT-3 in immune cells
13) Confidence 0.37 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.44 Pain Relevance 0.15
In general the serine phosphorylated STAT3 is lower in the hALC group compared to the hHC group.
Negative_regulation (lower) of STAT3
14) Confidence 0.34 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.02 Pain Relevance 0.04
Thus, CDDO-Me may have therapeutic potential for hematological malignancies and solid tumors through inactivation of Stat3 [215].
Negative_regulation (inactivation) of Stat3 associated with solid tumor and hematologic neoplasms
15) Confidence 0.33 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.99 Pain Relevance 0.04
agonists as inhibitors of Stat3 and NF-?
Negative_regulation (inhibitors) of Stat3 associated with agonist
16) Confidence 0.33 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.38 Pain Relevance 0.23
There was a significant reduction in TLR4 mRNA expression following PAF stimulation in those cells pretreated with Tyrphostin AG490 (an indirect STAT3 inhibitor, via JAK2 inhibition), Bay 11–7082 (an inhibitor of NF?
Negative_regulation (inhibitor) of STAT3
17) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.11 Pain Relevance 0.03
PAF caused a translocation of STAT3 from the cytosol to the nuclei of enterocytes and the PAF-induced induction of TLR4 expression was inhibited by pharmacological inhibition of the STAT3 and NFkB signaling pathways.


Negative_regulation (inhibition) of STAT3 in enterocytes
18) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.66 Pain Relevance 0.14
To further address the potential mechanism of PAF-induced TLR4 upregulation, we pretreated IEC-6 cells with inhibitors of STAT3 and NF-?
Negative_regulation (inhibitors) of STAT3 in IEC-6
19) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0 Pain Relevance 0
Furthermore, when Stat3 is inhibited, tumor cells will no longer express proangiogenic mediators in response to IL-6R signaling.
Negative_regulation (inhibited) of Stat3 associated with cancer
20) Confidence 0.25 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.12 Pain Relevance 0.08

General Comments

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