INT91374

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.06
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1)
cytoplasm (Nfkb1) cytosol (Nfkb1) signal transduction (Nfkb1)
Anatomy Link Frequency
nervous tissue 2
HeLa S3 2
bowel 2
intestine 2
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 15 100.00 Very High Very High Very High
ketamine 4 99.98 Very High Very High Very High
Neuritis 4 99.80 Very High Very High Very High
Inflammation 15 99.44 Very High Very High Very High
anesthesia 6 97.96 Very High Very High Very High
Peripheral nerve injury 6 95.72 Very High Very High Very High
ischemia 6 94.56 High High
cINOD 3 75.12 Quite High
COX-2 inhibitor 4 75.00 Quite High
Sciatic nerve 9 50.00 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 3 100.00 Very High Very High Very High
Necrosis 3 100.00 Very High Very High Very High
Cancer 8 99.98 Very High Very High Very High
Experimental Autoimmune Neuritis 3 99.80 Very High Very High Very High
Myocardial Reperfusion Injury 1 99.76 Very High Very High Very High
INFLAMMATION 21 99.44 Very High Very High Very High
Apoptosis 11 99.10 Very High Very High Very High
Injury 22 98.72 Very High Very High Very High
Immunization 1 98.44 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

2 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal injection of antisense ODN markedly suppressed the expression of NF-kappaB p65 protein and significantly attenuated CCI-induced mechanical allodynia and thermal hyperalgesia.
Negative_regulation (suppressed) of Gene_expression (expression) of NF-kappaB
1) Confidence 0.58 Published 2006 Journal Br J Anaesth Section Body Doc Link 16885169 Disease Relevance 0.22 Pain Relevance 0
Ketamine suppresses endotoxin-induced NF-kappaB activation and cytokines production in the intestine.
Negative_regulation (suppresses) of Gene_expression (production) of NF-kappaB in intestine associated with ketamine and cytokine
2) Confidence 0.47 Published 2004 Journal Acta Anaesthesiol Scand Section Title Doc Link 14982564 Disease Relevance 0.27 Pain Relevance 0.38
Expression of NF-kappaB and its mRNA and intercellular adhesion molecule-1 mRNA was significantly increased in the CAO group compared with the sham group and was significantly decreased in the T + CAO animals.
Negative_regulation (decreased) of Gene_expression (Expression) of NF-kappaB
3) Confidence 0.43 Published 2009 Journal Eur J Anaesthesiol Section Body Doc Link 19829116 Disease Relevance 0.05 Pain Relevance 0
CY prophylaxis (day 0 and 14 post-immunization [p.i.]) effectively prevents clinical and histological signs of EAN and also reduces the cytokine and the NF-kappaB p65 expression in the nervous tissue.
Negative_regulation (reduces) of Gene_expression (expression) of NF-kappaB p65 in nervous tissue associated with immunization, neuritis and cytokine
4) Confidence 0.35 Published 2008 Journal J. Neuroimmunol. Section Abstract Doc Link 18452999 Disease Relevance 0.74 Pain Relevance 0.34
COX-2: cyclooxygenase-2; SFI: sciatic functional index; CLX: celecoxib; TNF-alpha: tumour necrosis factor alpha; NF-kappaB: nuclear factor kappa b; SD: standard deviation.


Negative_regulation (necrosis) of Gene_expression (alpha) of NF-kappaB associated with necrosis and cancer
5) Confidence 0.29 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2607269 Disease Relevance 0.85 Pain Relevance 0.33
The inhibition on NF-kappaB activation, adhesion molecule expression, and cytokine production may be one of the important mechanisms of myocardial protection of NCR.
Negative_regulation (inhibition) of Gene_expression (expression) of NF-kappaB associated with adhesions and cytokine
6) Confidence 0.10 Published 2005 Journal Shock Section Abstract Doc Link 16044078 Disease Relevance 0.43 Pain Relevance 0.32
Furthermore, ergolide-mediated protein kinase Calpha (PKCalpha) inhibition is involved in reduction of NF-kappaB inhibition, as demonstrated by the observation that dominant negative PKCalpha, but not p44/42 MAPK and p38 MAPK, inhibits TPA-stimulated reporter gene expression.
Negative_regulation (reduction) of Neg (inhibition) Gene_expression (inhibition) of NF-kappaB
7) Confidence 0.09 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17430640 Disease Relevance 0 Pain Relevance 0.07
METHODS: Immunohistochemistry was used to detect the expression of TLR4, MD-2, and NF-kappaB in the colon mucosa specimens of 30 patients with diarrhea-predominant irritable bowel syndrome (IBS-D) and 12 healthy volunteers obtained by colonoscopy.
Negative_regulation (detect) of Gene_expression (expression) of NF-kappaB in bowel
8) Confidence 0.05 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 19159572 Disease Relevance 0 Pain Relevance 0
It also decreased the levels of COX-2 mRNA, COX-2 protein and nuclear NF-kappaB protein and increased the cytoplasmic I kappaB protein in the cancer.
Negative_regulation (decreased) of Gene_expression (levels) of NF-kappaB associated with cancer
9) Confidence 0.04 Published 2008 Journal Int. J. Cancer Section Abstract Doc Link 18058818 Disease Relevance 0.86 Pain Relevance 0.14
In addition, CPDHC (1) and DHPC (2) inhibit the AP-1 and NF-kappaB mediated SEAP expression in transiently transfected HeLa S3 cells with IC(50) values of 10-15 microM (2-3 microg/ml) and 50-100 microM (8-16 microg/ml) respectively.
Negative_regulation (inhibit) of Gene_expression (expression) of NF-kappaB in HeLa S3
10) Confidence 0.03 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11027495 Disease Relevance 0.14 Pain Relevance 0.07
Bee venom specifically suppressed the phosphorylation of p38/JNK and at the same time, suppressed the protein expression, DNA binding and promoter activity of NF-kappaB.
Negative_regulation (suppressed) of Gene_expression (expression) of NF-kappaB
11) Confidence 0.03 Published 2010 Journal J Ethnopharmacol Section Body Doc Link 19969058 Disease Relevance 0.23 Pain Relevance 0
Moreover, NAC has been shown to prevent H–R or I–R induced injury via both apoptotic and inflammatory pathways which include the inhibition of NF-kappa B expression as well as caspase-3 activity [17], [18].
Negative_regulation (inhibition) of Gene_expression (expression) of NF-kappa B associated with inflammation, injury and apoptosis
12) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3006425 Disease Relevance 1.17 Pain Relevance 0.10

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