INT91384

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.42
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A2) extracellular region (COL1A2) protein binding, bridging (COL1A2)
Anatomy Link Frequency
Cleavage 2
COL1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 85.80 High High
Rsd 2 81.72 Quite High
Osteoarthritis 45 76.16 Quite High
metalloproteinase 3 74.16 Quite High
Inflammation 2 67.04 Quite High
Arthritis 1 66.00 Quite High
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 22 95.64 Very High Very High Very High
Disease 5 94.16 High High
Pain 3 85.80 High High
Complex Regional Pain Syndromes 2 81.72 Quite High
Osteoarthritis 45 76.16 Quite High
Obesity 24 68.64 Quite High
Injury 1 68.28 Quite High
Arthritis 1 67.04 Quite High
Stress 3 65.56 Quite High
Sclerosis 1 28.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical tests were normal except for an increase in urinary excretion of the N-telopeptide cross-linking region of type I collagen (NTx).
Neg (except) Positive_regulation (increase) of Localization (excretion) of type I collagen
1) Confidence 0.49 Published 2000 Journal J. Bone Miner. Res. Section Abstract Doc Link 11028460 Disease Relevance 0.33 Pain Relevance 0.33
Cleavage of type I collagen results in release of C-terminal telopeptide of collagen type I (CTX-I) [20,21], which has been used extensively as a surrogate measure of bone resorption for in vitro, preclinical and clinical studies [20,22].
Positive_regulation (results) of Localization (Cleavage) of type I collagen in Cleavage associated with hypercalcemia
2) Confidence 0.05 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2902412 Disease Relevance 1.02 Pain Relevance 0.38
Furthermore, EGCG inhibited ethanol-induced type-I procollagen production and collagen secretion.
Positive_regulation (induced) of Localization (secretion) of procollagen
3) Confidence 0.00 Published 2006 Journal Eur. J. Clin. Invest. Section Body Doc Link 16436093 Disease Relevance 0.07 Pain Relevance 0

General Comments

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