INT91398

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Context Info
Confidence 0.59
First Reported 2000
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.84
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RARA) signal transduction (RARA) nucleus (RARA)
enzyme binding (RARA) transcription factor binding (RARA) cytoplasm (RARA)
RARA (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 2 95.44 Very High Very High Very High
agonist 17 93.56 High High
Inflammatory mediators 2 82.40 Quite High
Opioid 3 81.68 Quite High
opioid receptor 1 80.56 Quite High
MU agonist 2 66.56 Quite High
Enkephalin 1 63.20 Quite High
alcohol 3 56.48 Quite High
antagonist 10 50.76 Quite High
Inflammatory response 18 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cancer 55 100.00 Very High Very High Very High
Apoptosis 104 99.88 Very High Very High Very High
Rheumatoid Arthritis 95 99.26 Very High Very High Very High
Breast Cancer 84 97.76 Very High Very High Very High
Stress 1 96.88 Very High Very High Very High
Ganglion Cysts 24 91.68 High High
Lung Cancer 7 85.64 High High
Uterine Fibroids 72 82.96 Quite High
INFLAMMATION 41 82.00 Quite High
Nicotine Addiction 15 80.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Retinoic acid receptor (RAR)-alpha was not affected by treatment and RAR-alpha was moderately influenced whereas RAR-beta (concomitantly with transforming growth factor-beta) was induced in 33% of patients by ATRA alone.
Neg (not) Regulation (affected) of Retinoic acid receptor
1) Confidence 0.59 Published 2000 Journal Int. J. Oncol. Section Abstract Doc Link 11029503 Disease Relevance 0.43 Pain Relevance 0
Retinoic acid receptor (RAR)-alpha was not affected by treatment and RAR-alpha was moderately influenced whereas RAR-beta (concomitantly with transforming growth factor-beta) was induced in 33% of patients by ATRA alone.
Neg (not) Regulation (affected) of RAR
2) Confidence 0.26 Published 2000 Journal Int. J. Oncol. Section Abstract Doc Link 11029503 Disease Relevance 0.42 Pain Relevance 0
As shown in Figure 7B, expression of neither native DREAM nor the EF-LCDmut affected significantly the activity of GAL-VDR or GAL-RAR in the absence of ligand.
Regulation (affected) of GAL-RAR
3) Confidence 0.15 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.08 Pain Relevance 0
is the receptor solely sufficient for the growth inhibition, cell cycle arrest, apoptosis, and modulation of RAR levels [33].
Regulation (modulation) of RAR associated with apoptosis
4) Confidence 0.15 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2949655 Disease Relevance 1.14 Pain Relevance 0
modulates the transcriptional activity of RAR [32].
Regulation (modulates) of RAR
5) Confidence 0.15 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2949655 Disease Relevance 0.95 Pain Relevance 0
This does not appear to be a direct effect of the neurokinin on the RAR fiber.
Regulation (effect) of RAR
6) Confidence 0.08 Published 2001 Journal Respir Res Section Body Doc Link PMC59581 Disease Relevance 0.60 Pain Relevance 0.65
RA acts on tumor growth by binding and regulating the tumor cell heterodimeric receptors RAR and RXR.
Regulation (regulating) of RAR associated with cancer and rheumatoid arthritis
7) Confidence 0.07 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 1.31 Pain Relevance 0.03
There is also evidence that BC supplementation can result in a changed regulation of the transcription factor retinoic acid receptor (RAR) [15].
Regulation (regulation) of retinoic acid receptor
8) Confidence 0.03 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2877315 Disease Relevance 0.91 Pain Relevance 0

General Comments

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