INT914

Context Info Confidence 0.69 First Reported 1979 Last Reported 2011 Negated 23 Speculated 8 Reported most in Abstract Documents 292 Total Number 300 Disease Relevance 100.70 Pain Relevance 84.91

extracellular space (GH1) extracellular region (GH1)

Anatomy Link Frequency plasma 50 pituitary 12 blood 4 thyroid 4 body 4 GH1 (Homo sapiens)

Pain Link Frequency Relevance Heat Clonidine 500 100.00 agonist 457 100.00 dexamethasone 54 100.00 noradrenaline 10 100.00 Opioid receptor 1 2 100.00 substance P 2 100.00 Opioid 69 99.98 Morphine 24 99.98 Sumatriptan 16 99.98 narcan 206 99.84

Disease Link Frequency Relevance Heat Hypoglycemia 159 100.00 Renal Failure 80 99.98 Reprotox - General 1 50 99.96 Polyostotic Fibrous Dysplasia 128 99.90 Cancer 1071 99.88 Growth Problems 587 99.88 Acromegaly 883 99.84 Hypertension 75 99.84 Stress 145 99.80 Weight Gain 139 99.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Laboratory studies documented no accumulation of trough GH or IGF-I levels during treatment, nor did glucose intolerance or persistent hyperinsulinism develop.

Neg (no) Positive_regulation (accumulation) of GH associated with hyperinsulinism and impaired glucose tolerance

1) Confidence 0.69 Published 2001 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 11600528 Disease Relevance 0.38 Pain Relevance 0.09

In normal weight controls, instead, a significant increase of GH values was reached at 90' (P less than 0.05) and at 120' (P less than 0.05) after clonidine.

Positive_regulation (increase) of GH associated with clonidine

2) Confidence 0.69 Published 1988 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 3243343 Disease Relevance 0.58 Pain Relevance 0.80

Sumatriptan increased plasma growth hormone (GH) levels from 2.5 +/- 0.5 mIU/l in basal conditions to 17.3 +/- 2.6 mIU/l 30 min after administration of the drug.

Positive_regulation (increased) of GH in plasma associated with sumatriptan

3) Confidence 0.69 Published 1994 Journal Neuropharmacology Section Abstract Doc Link 8035909 Disease Relevance 0.09 Pain Relevance 0.48

Clonidine alone decreased blood pressure and heart rate and increased HGH levels, while naloxone pretreatment, in the whole range of doses studied, did not significantly modify the action of clonidine.

Positive_regulation (increased) of HGH in blood associated with pressure volume 2 under development, narcan and clonidine

4) Confidence 0.69 Published 1985 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2413307 Disease Relevance 0.18 Pain Relevance 1.19

Clonidine decreased blood pressure and heart rate, and increased HGH levels.

Positive_regulation (increased) of HGH in blood associated with pressure volume 2 under development and clonidine

5) Confidence 0.69 Published 1985 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2413307 Disease Relevance 0.16 Pain Relevance 1.21

We have administered the long-acting met-enkephalin analogue DAMME to 6 normal males, and have shown that the resulting elevation in GH is blocked by the specific cholinergic antagonist, pirenzepine.

Positive_regulation (elevation) of GH associated with antagonist and enkephalin

6) Confidence 0.68 Published 1983 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 6409456 Disease Relevance 0 Pain Relevance 0.40

An increase in interpulse GH values was also observed during GRF infusion.

Positive_regulation (increase) of GH

7) Confidence 0.68 Published 1991 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 1934527 Disease Relevance 0 Pain Relevance 0

RESULTS: Clonidine induced a slight but significant increase in plasma GH values, peaking 60 to 120 minutes later; however, no significant changes were observed in indices of total and pulsatile GH release for the whole sampling period in this study.

Positive_regulation (increase) of GH in plasma

8) Confidence 0.68 Published 1991 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 1934527 Disease Relevance 0 Pain Relevance 0

These results indicate that the increase in plasma GH induced by alpha 2-adrenergic stimulation in normotensive subjects involves opioid receptors with moderate sensitivity to naloxone.

Positive_regulation (increase) of GH in plasma associated with narcan and opioid receptor

9) Confidence 0.68 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 2881420 Disease Relevance 0 Pain Relevance 0.92

Both clonidine and guanfacine induced an increase in plasma GH (P less than 0.05).

Positive_regulation (increase) of GH in plasma associated with clonidine

10) Confidence 0.68 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 2881420 Disease Relevance 0 Pain Relevance 1.00

The increase in plasma GH did not correlate with basal mean arterial blood pressure, nor with the changes in mean arterial blood pressure induced by clonidine or guanfacine.

Positive_regulation (increase) of GH in plasma associated with clonidine

11) Confidence 0.68 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 2881420 Disease Relevance 0 Pain Relevance 0.98

These results indicate that the increase in plasma GH induced by alpha 2-adrenergic stimulation in normotensive subjects involves opioid receptors with moderate sensitivity to naloxone.

Positive_regulation (induced) of GH in plasma associated with narcan and opioid receptor

12) Confidence 0.68 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 2881420 Disease Relevance 0 Pain Relevance 0.91

In the present investigations, the effect of naloxone on the increase in plasma GH induced by clonidine and the more specific alpha 2-agonist guanfacine was studied in man.

Positive_regulation (increase) of GH in plasma associated with agonist, narcan and clonidine

13) Confidence 0.68 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 2881420 Disease Relevance 0 Pain Relevance 0.72

In the present investigations, the effect of naloxone on the increase in plasma GH induced by clonidine and the more specific alpha 2-agonist guanfacine was studied in man.

Positive_regulation (induced) of GH in plasma associated with agonist, narcan and clonidine

14) Confidence 0.68 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 2881420 Disease Relevance 0 Pain Relevance 0.72

In contrast, alpha-adrenergic receptor agonism with either propranolol-adrenaline infusion or clonidine increased plasma GH levels at a time when GH responses to this supramaximal dose of GRF were absent.

Positive_regulation (increased) of GH in plasma associated with clonidine

15) Confidence 0.68 Published 1988 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 2855221 Disease Relevance 0 Pain Relevance 0.10

Administration of a supramaximal dose of GRF 1-44 (200 micrograms, i.v.) to normal human volunteers increased GH levels while a further bolus of GRF (200 micrograms i.v.) given 2 hours later failed to increase plasma GH levels.

Positive_regulation (increased) of GH in plasma

16) Confidence 0.68 Published 1988 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 2855221 Disease Relevance 0 Pain Relevance 0.08

Administration of a supramaximal dose of GRF 1-44 (200 micrograms, i.v.) to normal human volunteers increased GH levels while a further bolus of GRF (200 micrograms i.v.) given 2 hours later failed to increase plasma GH levels.

Neg (failed) Positive_regulation (increase) of GH in plasma

17) Confidence 0.68 Published 1988 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 2855221 Disease Relevance 0 Pain Relevance 0.09

In the 14 acromegalic patients studied, the GHRH-induced GH net increase was similar to that observed in controls, while the placebo did not alter GH basal levels.

Positive_regulation (increase) of GH

18) Confidence 0.68 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8284031 Disease Relevance 0.15 Pain Relevance 0.43

Administration of the alpha 2-adrenoreceptor agonist clonidine (0.5 mg po) reliably increased GH levels (P less than 0.05).

Positive_regulation (increased) of GH associated with agonist and clonidine

19) Confidence 0.68 Published 1985 Journal Metab. Clin. Exp. Section Abstract Doc Link 3982277 Disease Relevance 0.07 Pain Relevance 0.54

Elevated GH levels following clonidine administration abolished GH responses to subsequently infused 2DG (P less than 0.05).

Positive_regulation (Elevated) of GH associated with clonidine

20) Confidence 0.68 Published 1985 Journal Metab. Clin. Exp. Section Abstract Doc Link 3982277 Disease Relevance 0.07 Pain Relevance 0.57

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