INT91418

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Context Info
Confidence 0.62
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 1.12
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrg1) plasma membrane (Gabrg1)
Anatomy Link Frequency
neurons 1
Purkinje cell 1
hippocampus 1
Gabrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 284 100.00 Very High Very High Very High
antagonist 47 99.96 Very High Very High Very High
Hippocampus 51 99.48 Very High Very High Very High
Central nervous system 12 98.36 Very High Very High Very High
projection neuron 95 97.40 Very High Very High Very High
Enkephalin 56 97.16 Very High Very High Very High
substance P 48 96.68 Very High Very High Very High
GABAergic 147 91.92 High High
Pyramidal cell 82 91.44 High High
GABA receptor 21 84.08 Quite High
Disease Link Frequency Relevance Heat
Cancer 74 99.12 Very High Very High Very High
Neurodegenerative Disease 19 99.12 Very High Very High Very High
Bone Cancer 41 62.56 Quite High
Death 3 53.76 Quite High
Sprains And Strains 45 46.96 Quite Low
Hyperalgesia 5 18.68 Low Low
Anxiety Disorder 6 18.24 Low Low
Heart Rate Under Development 7 11.28 Low Low
Sudden Death 1 10.32 Low Low
Ataxia 6 9.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitory effect of 1 mM GABA persisted when it was applied in the presence of the GABAA receptor antagonist SR-95531 (40 ?
Transcription (presence) of GABAA associated with gaba and antagonist
1) Confidence 0.62 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.65
Using real-time RT-PCR, mRNA expression levels of GABAA receptor subunits ?
Transcription (expression) of GABAA receptor
2) Confidence 0.54 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1544347 Disease Relevance 0.05 Pain Relevance 0.08
Following the harvesting of the cytoplasmic contents of individual GnRH neurons, single cell multiplex RT-PCR experiments demonstrated that GABAA receptor alpha1-5, beta1-3 and gamma2 & 3 subunit transcripts were expressed by both neonatal (postnatal day 5) and juvenile (day 15-20) GnRH neurons in a heterogeneous manner.
Transcription (transcripts) of GABAA in neurons
3) Confidence 0.52 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11029619 Disease Relevance 0 Pain Relevance 0.20
3(N265M) mice [9] is really due to the point mutation in the GABAA receptor ?
Transcription (mutation) of GABAA receptor
4) Confidence 0.49 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC1810244 Disease Relevance 0 Pain Relevance 0
Tonic versus phasic GABA activity
Transcription (activity) of GABA associated with gaba
5) Confidence 0.43 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2859806 Disease Relevance 0.32 Pain Relevance 0.18
1 is the most abundant of the GABAA subunits and is often co-localized with ?
Transcription (abundant) of GABAA
6) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816210 Disease Relevance 0 Pain Relevance 0.36
Transient change in GABAA receptor subunit mRNA expression in Lurcher cerebellar nuclei during Purkinje cell degeneration

Background

Transcription (expression) of GABAA receptor subunit in Purkinje cell
7) Confidence 0.35 Published 2006 Journal BMC Neurosci Section Title Doc Link PMC1544347 Disease Relevance 0 Pain Relevance 0.11
To test whether differences in GABAA-receptor subunits exist in hippocampus of NOD and Balbc mice, we compared mRNA levels of different GABAA-receptor subunits in hippocampus.
Transcription (levels) of GABAA-receptor in hippocampus associated with hippocampus
8) Confidence 0.25 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0 Pain Relevance 0.53
Figures 2B,F show that the action of the GABAA receptor blocker, 10??
Transcription (action) of GABAA receptor
9) Confidence 0.11 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2893005 Disease Relevance 0 Pain Relevance 0.77
In the presence of a GABAA receptor antagonist bicuculline (10 ?
Transcription (presence) of GABAA receptor associated with antagonist
10) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC3020802 Disease Relevance 0.74 Pain Relevance 0.13
We next recorded cells in current clamp and examined the EPSP waveform in the presence of the GABAA receptor antagonist picrotoxin (50 ?
Transcription (presence) of GABAA receptor associated with antagonist
11) Confidence 0.04 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.16

General Comments

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