INT91420

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.07
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1)
Anatomy Link Frequency
neurons 3
neuronal 2
telencephalon 1
Gnrh1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 5 100.00 Very High Very High Very High
GABAergic 1 82.28 Quite High
tetrodotoxin 1 81.12 Quite High
Neuropeptide 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Virilism 15 75.00 Quite High
Congenital Anomalies 2 46.72 Quite Low
Lordosis 2 25.00 Low Low
Aids-related Complex 81 18.16 Low Low
Aggression 7 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Neuroblastoma 2 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low
Nervous System Malformation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Testicular development is arrested in the hypogonadal (hpg) mouse due to a congenital deficiency in hypothalamic gonadotropin-releasing hormone (GnRH) synthesis.
Negative_regulation (deficiency) of Gene_expression (synthesis) of GnRH
1) Confidence 0.43 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1249589 Disease Relevance 0.07 Pain Relevance 0
These findings provide the first electrical and molecular characterization of the GnRH phenotype and demonstrate a novel pattern of late postnatal reorganization of native GABA(A) receptor gene expression and signalling in the GnRH neuronal population.
Negative_regulation (reorganization) of Gene_expression (expression) of GnRH in neuronal associated with gaba
2) Confidence 0.43 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11029619 Disease Relevance 0 Pain Relevance 0.32
In contrast, the difference between sexes was not detected in hpg mice, consistent with our observations by ISH and ICC, further corroborating the loss of sexual dimorphism of kisspeptin expression in the AVPV of hpg mice.
Negative_regulation (dimorphism) of Gene_expression (expression) of hpg
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0 Pain Relevance 0
PN-1 immunoreactivity was also present within the basal laminae of the vomeronasal organ, a barrier crossed by GnRH neurons when they initiate their migration.
Negative_regulation (crossed) of Gene_expression (neurons) of GnRH in neurons
4) Confidence 0.29 Published 2002 Journal BMC Dev Biol Section Body Doc Link PMC65692 Disease Relevance 0 Pain Relevance 0
Application of type IV chicken ovoinhibitor led to a decrease in the percent of GnRH neurons remaining in the OE (P < 0.02) and a larger percent within the telencephalon (P < 0.03).
Negative_regulation (decrease) of in neurons Gene_expression (neurons) of GnRH in telencephalon
5) Confidence 0.29 Published 2002 Journal BMC Dev Biol Section Body Doc Link PMC65692 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox