INT91429

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 34
Total Number 34
Disease Relevance 17.67
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CD44) plasma membrane (CD44)
Anatomy Link Frequency
extracellular matrix 3
lung 2
tube 1
macrophages 1
immune cells 1
CD44 (Homo sapiens)
Pain Link Frequency Relevance Heat
Snapping jaw 7 99.62 Very High Very High Very High
metalloproteinase 188 94.20 High High
fibrosis 94 93.08 High High
antagonist 3 92.60 High High
lidocaine 6 91.48 High High
COX2 2 90.44 High High
cytokine 42 88.68 High High
Nicotine 120 88.08 High High
anesthesia 3 73.12 Quite High
Inflammation 397 72.08 Quite High
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 7 99.62 Very High Very High Very High
Osteoarthritis 14 99.56 Very High Very High Very High
Nicotine Addiction 2198 98.80 Very High Very High Very High
Cancer 488 98.60 Very High Very High Very High
Hypercalcemia 58 98.46 Very High Very High Very High
Apoptosis 88 97.92 Very High Very High Very High
Prostate Cancer 440 97.80 Very High Very High Very High
Carcinoma 73 97.64 Very High Very High Very High
Metastasis 246 97.48 Very High Very High Very High
Skin Cancer 68 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunostaining analysis revealed that the interaction of hZip-1 with either CD44 or MMP-9 was negligible or not at all observed (data not shown).
CD44 Binding (interaction) of
1) Confidence 0.41 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.20 Pain Relevance 0
Other studies have suggested that sCD44 variants can bind hyaluronate, and that the affinity of binding is determined by specific glycosylations [196,215].
sCD44 Binding (bind) of
2) Confidence 0.40 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 0.19 Pain Relevance 0
Other studies have suggested that sCD44 variants can bind hyaluronate, and that the affinity of binding is determined by specific glycosylations [196,215].
sCD44 Binding (bind) of
3) Confidence 0.40 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 0.19 Pain Relevance 0
Thus, osteoclasts appear to either select an optimized function, namely secreting proteolytic enzymes from ruffled borders during bone resorption, or recognize the surrounding extracellular matrix by mediating osteopontin/CD44 interaction, and internalize the extracellular matrices.
CD44 Binding (interaction) of in extracellular matrix associated with hypercalcemia
4) Confidence 0.38 Published 2006 Journal Microsc. Res. Tech. Section Abstract Doc Link 16456838 Disease Relevance 0.52 Pain Relevance 0
In normal TMJ discs, a moderate immunolabelling with anti-CD44H antibodies was detectable in fibroblastlike cells, in the few fibrochondrocytes and in chondrocytelike cells.
CD44H Binding (immunolabelling) of in TMJ associated with snapping jaw
5) Confidence 0.37 Published 2000 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 11030403 Disease Relevance 0.67 Pain Relevance 0.43
Proof of the CD44 membrane protein was performed by flow cytometry with an FITC-conjugated CD44 antibody (anti-CD44H-FITC).
CD44 Binding (cytometry) of
6) Confidence 0.37 Published 2005 Journal Int. J. Mol. Med. Section Abstract Doc Link 15942692 Disease Relevance 0.39 Pain Relevance 0.43
Veriscan interacts with hyaluronan and CD44 and increase the viscoelastic nature of the pericellular matrix, creating a highly malleable extracellular environment that supports a cell-shape change necessary for cell proliferation and migration [30].
CD44 Binding (interacts) of
7) Confidence 0.34 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 0.90 Pain Relevance 0
Fluorescence cytochemistry demonstrated that HA bound to CD44, the principal HA receptor, on U937 macrophages.
CD44 Binding (bound) of in macrophages
8) Confidence 0.33 Published 2010 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 20208419 Disease Relevance 0.46 Pain Relevance 0.37
Disruption of CD44/MMP-9 cluster formation, by over expression of soluble or truncated cell surface CD44 reduces tumor invasiveness in vivo [19].
CD44 Binding (formation) of associated with cancer
9) Confidence 0.32 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.96 Pain Relevance 0.31
The effect of BPs on the surface interaction of CD44 and MMP-9 was analyzed by immunostaining analysis with respective antibodies in cells that were neither fixed with paraformaldehyde nor permeablized with Triton X-100 (Figure 5).
CD44 Binding (interaction) of
10) Confidence 0.32 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.21 Pain Relevance 0
The effects of BPs on the surface interaction of MMP-9 and CD44
CD44 Binding (interaction) of
11) Confidence 0.32 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.26 Pain Relevance 0.03
Metastasis to the lung following intravenous delivery of TA3/St murine mammary carcinoma cells is prevented when the carcinoma cells are transfected with sCD44-encoding cDNA, where sCD44 probably acts as a competitive inhibitor of cell surface CD44-hyaluronate interactions [216].
CD44-hyaluronate Binding (interactions) of in lung associated with carcinoma and metastasis
12) Confidence 0.31 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 0.67 Pain Relevance 0
This unusual and unexpected observation has been suggested to result from CD44RC binding to chondroitin sulfate side-chains attached to cell surface CD44.
CD44RC Binding (binding) of
13) Confidence 0.31 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 0.05 Pain Relevance 0.03
This unusual and unexpected observation has been suggested to result from CD44RC binding to chondroitin sulfate side-chains attached to cell surface CD44.
CD44RC Binding (binding) of
14) Confidence 0.31 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 0.05 Pain Relevance 0.03
Smoking directly causes an increase in soluble ICAM-1 and specific CD44 variant concentrations in the systemic circulation, diluting several previous diagnostic and prognostic attributions.
CD44 Binding (concentrations) of associated with nicotine addiction
15) Confidence 0.31 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.33 Pain Relevance 0
Therefore, it may be useful to address the influence of tobacco on the expression of membrane-bound CD44 isoforms in situ in a definitive manner in future studies.
CD44 Binding (bound) of
16) Confidence 0.31 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 0.59 Pain Relevance 0.10
Metastasis to the lung following intravenous delivery of TA3/St murine mammary carcinoma cells is prevented when the carcinoma cells are transfected with sCD44-encoding cDNA, where sCD44 probably acts as a competitive inhibitor of cell surface CD44-hyaluronate interactions [216].
CD44-hyaluronate Binding (interactions) of in lung associated with carcinoma and metastasis
17) Confidence 0.31 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 0.67 Pain Relevance 0
Smoking directly causes an increase in soluble ICAM-1 and specific CD44 variant concentrations in the systemic circulation, diluting several previous diagnostic and prognostic attributions.
CD44 Binding (concentrations) of associated with nicotine addiction
18) Confidence 0.31 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.33 Pain Relevance 0
Therefore, it may be useful to address the influence of tobacco on the expression of membrane-bound CD44 isoforms in situ in a definitive manner in future studies.
CD44 Binding (bound) of
19) Confidence 0.31 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 0.59 Pain Relevance 0.10
OPN/CD44 interaction was shown to be required for cell migration and CD44 synthesis [6].
CD44 Binding (interaction) of
20) Confidence 0.30 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox