INT91430

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Context Info
Confidence 0.69
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 15.43
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CD44) plasma membrane (CD44)
Anatomy Link Frequency
blood 2
extracellular matrix 2
macrophage 1
bone marrow 1
TMJ 1
CD44 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 87 99.96 Very High Very High Very High
Snapping jaw 8 99.32 Very High Very High Very High
cytokine 57 96.80 Very High Very High Very High
Inflammation 277 94.88 High High
chemokine 15 86.20 High High
transdermal 16 77.36 Quite High
Nicotine 80 76.40 Quite High
COX-2 inhibitor 4 73.92 Quite High
cINOD 7 66.12 Quite High
Osteoarthritis 37 51.12 Quite High
Disease Link Frequency Relevance Heat
Adhesions 801 100.00 Very High Very High Very High
Pulmonary Fibrosis 65 99.96 Very High Very High Very High
Osteoarthritis 7 99.92 Very High Very High Very High
Nicotine Addiction 1467 99.68 Very High Very High Very High
Temporomandibular Joint Syndrome 8 99.32 Very High Very High Very High
Metastasis 101 97.96 Very High Very High Very High
Cancer 278 97.46 Very High Very High Very High
Apoptosis 58 96.96 Very High Very High Very High
Fibrosis 15 96.68 Very High Very High Very High
INFLAMMATION 327 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The up-regulation of CD44H observed in some dysfunctional TMJ discs seems to indicate a prevention of apoptosis in fibroblastlike cells and an important role in phenotypical change of fibrochondrocytes into chondroblastlike cells, enabling the aggregation of chondroid tissue pericellular matrix components.
Positive_regulation (up-regulation) of CD44H in TMJ associated with snapping jaw and apoptosis
1) Confidence 0.69 Published 2000 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 11030403 Disease Relevance 0.85 Pain Relevance 0.54
An increase in CD44-associated MMP- 9 activity was observed on the surface of PC3/OPN cells (Panel A, lane 4).
Positive_regulation (increase) of CD44-associated
2) Confidence 0.59 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.32 Pain Relevance 0
Analysis of cell surface markers showed a significant increase in CD44 with the TGF-beta 3 + BMP-4 treatment compared to the controls.
Positive_regulation (increase) of CD44
3) Confidence 0.59 Published 2009 Journal Stem Cells Dev. Section Abstract Doc Link 18454697 Disease Relevance 0.06 Pain Relevance 0.06
6 × 106 Da, proposing that the effect derived from the increased expression of granulocyte macrophage colony-stimulating factor after CD44 activation (Ohkawara et al 2000).


Positive_regulation (activation) of CD44 in macrophage
4) Confidence 0.51 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546480 Disease Relevance 0.33 Pain Relevance 0.17
It is unknown whether the expression of these receptors is changed in IPF; CD44 is expressed on lung fibroblasts and epithelial cells [43], is induced in radiation- and bleomycin-induced pulmonary fibrosis [44] and in acute alveolar fibrosis [45], and is critical for resolution of noninfectious lung inflammation [46].
Positive_regulation (induced) of CD44 in lung associated with fibrosis, inflammation, pneumonia and pulmonary fibrosis
5) Confidence 0.45 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.68 Pain Relevance 0.32
A significant increase in the coclustering of CD44 and MMP-9 on the cell surface of PC3/OPN cells as compared with PC3 cells (Figure 5A and 5B) suggest a plausible mechanism of activation of MMP-9 by CD44.


Positive_regulation (increase) of CD44
6) Confidence 0.43 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.22 Pain Relevance 0
Many of these activities appear to be mediated by interaction between the extracellular matrix component hyalouronate and CD44.
Positive_regulation (mediated) of CD44 in extracellular matrix
7) Confidence 0.42 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 0.67 Pain Relevance 0.03
Many of these activities appear to be mediated by interaction between the extracellular matrix component hyalouronate and CD44.
Positive_regulation (mediated) of CD44 in extracellular matrix
8) Confidence 0.42 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 0.67 Pain Relevance 0.03
In agreement with the data shown in Figure 2, OPN over expression was associated with an up-regulation of vCD44 on the cell surface (Figure 3B, lane 1) as compared with PC3 cells (lane 2).
Positive_regulation (regulation) of vCD44
9) Confidence 0.39 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0
Consistent with our previous observation [22], the observed increase in the surface level of CD44 is due to OPN/?
Positive_regulation (increase) of CD44
10) Confidence 0.39 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.24 Pain Relevance 0
Total sCD44 has since been shown to be elevated in the blood of smokers, compared to non-smokers [191], to a small, but significant, extent.
Positive_regulation (elevated) of sCD44 in blood associated with nicotine addiction
11) Confidence 0.39 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.10 Pain Relevance 0.06
Like sICAM-1, the elevations in CD44v5 and v6, but not total CD44, are dose-dependent and reversible [141].
Positive_regulation (elevations) of CD44
12) Confidence 0.39 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.13 Pain Relevance 0.08
In an investigation designed to examine the potential of specific reputed tumour-associated circulating sCD44 isoforms to act as biomarkers in certain malignancies, Kittl et al. [140] observed a significant elevation in the mean concentration of sCD44 containing the product of exon 5 (sCD44v5) and sCD44 containing the product of exon 6 (sCD44v6), in self-reported smokers, compared to self-reported non-smokers.
Positive_regulation (elevation) of sCD44 associated with nicotine addiction and cancer
13) Confidence 0.39 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.26 Pain Relevance 0
Total sCD44 has since been shown to be elevated in the blood of smokers, compared to non-smokers [191], to a small, but significant, extent.
Positive_regulation (elevated) of sCD44 in blood associated with nicotine addiction
14) Confidence 0.39 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.10 Pain Relevance 0.06
In an investigation designed to examine the potential of specific reputed tumour-associated circulating sCD44 isoforms to act as biomarkers in certain malignancies, Kittl et al. [140] observed a significant elevation in the mean concentration of sCD44 containing the product of exon 5 (sCD44v5) and sCD44 containing the product of exon 6 (sCD44v6), in self-reported smokers, compared to self-reported non-smokers.
Positive_regulation (elevation) of sCD44 associated with nicotine addiction and cancer
15) Confidence 0.39 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.26 Pain Relevance 0
Like sICAM-1, the elevations in CD44v5 and v6, but not total CD44, are dose-dependent and reversible [141].
Positive_regulation (elevations) of CD44
16) Confidence 0.39 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.13 Pain Relevance 0.08
Although with the absence of some key molecules in the activation of immune responses to facilitate the virus transformation, the transformed B lymphocytes from the cynomolgus monkey expressed more immunoglobulin and ligand and receptor genes than in human blood and lymph nodes, in numbers as well as in abundances; A B-cell specific proliferation pathway including MIF, CD74 and CD44 was greatly enhanced after transformation.
Positive_regulation (enhanced) of CD44 in B lymphocytes
17) Confidence 0.32 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1522023 Disease Relevance 0.12 Pain Relevance 0
These include decreased density, upregulation of surface activation molecules (e.g., CD69, CD25, CD44, and HLA-DR), enhanced cellular cytotoxicity, and release of granule proteins, cytokines, leukotrienes, and other mediators of inflammation (reviewed in [25]).
Positive_regulation (upregulation) of CD44 associated with inflammation and cytokine
18) Confidence 0.24 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.78 Pain Relevance 0.20
Enhanced binding of HA to pericellular hyaladherins and MPC receptors (for example, CD44) upregulated by PPS, however, could also be a consideration.
Positive_regulation (Enhanced) of CD44
19) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.10 Pain Relevance 0
At flow cytometry analysis AM-hMSCs showed an immunophenotypical profile, i.e., positive for CD105, CD73, CD29, CD44, CD166 and negative for CD14, CD34, CD45, consistent with that reported for bone marrow-derived MSCs.
Positive_regulation (positive) of CD44 in bone marrow
20) Confidence 0.18 Published 2007 Journal BMC Dev Biol Section Abstract Doc Link PMC1810523 Disease Relevance 0 Pain Relevance 0

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